Curcumin protects neural cells against ischemic injury in N2a cells and mouse brain with ischemic stroke

Xie, Caijun; Gu, Aiping; Cai, Jun; Wu, Yi; Chen, Ruicong

doi:10.1002/brb3.921

Cited by 72 publications

(41 citation statements)

References 47 publications

(80 reference statements)

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“…In the same model, curcumin administration reduced neuroinflammation by lowering the IL6, TNFα [117,121], and iNOS levels, and mediating autophagy activity via PI3K/Akt/mTOR [117,119]. Results similar to those described for rats were also obtained in a mouse model of local cerebral ischemia, in which administration of curcumin reduced cerebral infarction and neuronal apoptosis most likely by limitation of mitochondrial dysfunction [127]. In addition, curcumin has been found to improve neurological function score, maintain the integrity of the blood-brain barrier, and reduce the infarct volume of the cerebral cortex, and decrease mortality, as well as apoptosis of neurons in animal brain ischemia models [128][129][130].…”

Section: Neuroprotection and Neurogenesissupporting

confidence: 60%

Substantiation for the Use of Curcumin during the Development of Neurodegeneration after Brain Ischemia

Ułamek-Kozioł

Czuczwar

Januszewski

et al. 2020

IJMS

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Currently available pharmacological treatment of post-ischemia-reperfusion brain injury has limited effectiveness. This review provides an assessment of the current state of neurodegeneration treatment due to ischemia-reperfusion brain injury and focuses on the role of curcumin in the diet. The purpose of this review was to provide a comprehensive overview of what was published about the benefits of curcumin influence on post-ischemic brain damage. Some data on the clinical benefits of curcumin treatment of post-ischemic brain in terms of clinical symptoms and adverse reactions have been reviewed. The data in this review contributes to a better understanding of the potential benefits of curcumin in the treatment of neurodegenerative changes after ischemia and informs scientists, clinicians, and patients, as well as their families and caregivers about the possibilities of such treatment. Due to the pleotropic properties of curcumin, including anti-amyloid, anti-tau protein hyperphosphorylation, anti-inflammatory, anti-apoptotic, and neuroprotective action, as well as increasing neuronal lifespan and promoting neurogenesis, curcumin is a promising candidate for the treatment of post-ischemic neurodegeneration with misfolded proteins accumulation. In this way, it may gain interest as a potential therapy to prevent the development of neurodegenerative changes after cerebral ischemia. In addition, it is a safe substance and inexpensive, easily accessible, and can effectively penetrate the blood–brain barrier and neuronal membranes. In conclusion, the evidence available in a review of the literature on the therapeutic potential of curcumin provides helpful insight into the potential clinical utility of curcumin in the treatment of neurological neurodegenerative diseases with misfolded proteins. Therefore, curcumin may be a promising supplementary agent against development of neurodegeneration after brain ischemia in the future. Indeed, there is a rational scientific basis for the use of curcumin for the prophylaxis and treatment of post-ischemic neurodegeneration.

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Section: Neuroprotection and Neurogenesissupporting

confidence: 60%

Substantiation for the Use of Curcumin during the Development of Neurodegeneration after Brain Ischemia

Ułamek-Kozioł

Czuczwar

Januszewski

et al. 2020

IJMS

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“…These data were confirmed in a HUVECs cellular model, where curcumin treatment attenuated H 2 O 2 -induced oxidative stress [81]. Similar results were obtained from other animal and cellular models: curcumin treatment reduced cerebral infarction and neuronal apoptosis in a mouse model of middle cerebral artery occlusion (MCAO), and in N2a cells, it reduced mitochondrial dysfunction [86]. Moreover, using the MCAO rat model, it was observed that curcumin reduced infarct volume [87] and brain oedema at 24 h [88], prevented the development of post-ischemic neurodegeneration [89], and treated rats achieved better neurological scores compared to untreated rats [90,91].…”

Section: Strokesupporting

confidence: 79%

Curcumin Formulations and Trials: What’s New in Neurological Diseases

et al. 2020

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Curcumin’s pharmacological properties and its possible benefits for neurological diseases and dementia have been much debated. In vitro experiments show that curcumin modulates several key physiological pathways of importance for neurology. However, in vivo studies have not always matched expectations. Thus, improved formulations of curcumin are emerging as powerful tools in overcoming the bioavailability and stability limitations of curcumin. New studies in animal models and recent double-blinded, placebo-controlled clinical trials using some of these new formulations are finally beginning to show that curcumin could be used for the treatment of cognitive decline. Ultimately, this work could ease the burden caused by a group of diseases that are becoming a global emergency because of the unprecedented growth in the number of people aged 65 and over worldwide. In this review, we discuss curcumin’s main mechanisms of action and also data from in vivo experiments on the effects of curcumin on cognitive decline.

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“…The anti-inflammatory and anti-apoptotic effects of curcumin were reported previously [22,23]. Curcumin's neuro-protective effects were also found in many neuro-pathological models, including cerebral I/R in vivo and in vitro models [24,25]. Many mechanisms underlying curcumin's neuro-protective effects have been proposed.…”

Section: Discussionmentioning

confidence: 76%

Curcumin Suppresses Apoptosis and Inflammation in Hypoxia/Reperfusion-Exposed Neurons via Wnt Signaling Pathway

Zhou¹,

Wu²,

Lin³

2020

Med Sci Monit

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Background: Cerebral ischemia/reperfusion (I/R) injury contributes to mortality and morbidity in preterm infants. Curcumin has been shown to exert neuro-protective effects in the central nervous system (CNS). The aim of this study was to investigate the neuro-protective activity of curcumin and the possible underlying molecular mechanisms. Material/Methods: A hypoxia/reoxygenation (H/R) protocol was used to simulate I/R injury in vitro. Isolated neonatal neurons were pre-treated with curcumin at serially diluted concentrations and exposed to H/R injury. Cell viability and apoptosis were assessed by MTT and flow cytometry, respectively. Contents of TNFa and IL6 in supernatant of cell culture medium were detected by ELISA. Protein expression, phosphorylation, and nuclear translocation levels were studied by Western blotting. Results: H/R reduced cell viability and increased apoptosis of neurons. H/R significantly increased Wnt5a expression, JNK1 phosphorylation, and NF-kB nuclear translocation. Moreover, expression levels of cleaved caspase3, TNFa, and IL6 were elevated in H/R-exposed neurons. Curcumin pre-treatment significantly increased cell viability and inhibited apoptosis of neurons exposed to H/R, in a concentration-dependent manner. Moreover, curcumin pretreatment significantly decreased expression levels of Wnt5a, IL6, TNFa, and phosphorylation level of JNK1, as well as the nuclear translocation level of NF-kB in H/R-exposed neurons, in a concentration-dependent manner. Conclusions: Curcumin exerted neuro-protective effects against H/R-induced neuron apoptosis and inflammation by inhibiting activation of the Wnt/JNK1 signaling pathway.

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Curcumin protects neural cells against ischemic injury in N2a cells and mouse brain with ischemic stroke

Cited by 72 publications

References 47 publications

Substantiation for the Use of Curcumin during the Development of Neurodegeneration after Brain Ischemia

Substantiation for the Use of Curcumin during the Development of Neurodegeneration after Brain Ischemia

Curcumin Formulations and Trials: What’s New in Neurological Diseases

Curcumin Suppresses Apoptosis and Inflammation in Hypoxia/Reperfusion-Exposed Neurons via Wnt Signaling Pathway

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