Curcumin Protects Against Sepsis-Induced Acute Lung Injury in Rats

Xiao, Xiang; Yang, Mingshi; Sun, Dao; Sun, Shenghua

doi:10.1016/j.jss.2011.11.1032

Cited by 89 publications

(74 citation statements)

References 33 publications

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“…Curcumin therapy has been shown to protects against sepsis-induced acute lung injury by counteracting inflammatory cells infiltration and ROS generation, and regulating cytokine effects. 32 Curcumin also interferes with multiple steps of inflammatory kinases involving P13K-Akt, ERK1/2, P38, and JNK in regional myocardial ischemia/reperfusion injury rats. 33 In other studies, curcumin has been suggested to engage the NF-κB signal pathway in streptozotocin-induced diabetes, 34 caerulein-induced acute pancreatitis, 35 and traumatic brain injury.…”

Section: Discussionmentioning

confidence: 98%

Curcumin modulates TLR4/NF-κB inflammatory signaling pathway following traumatic spinal cord injury in rats

Jin

Zhu

et al. 2014

The Journal of Spinal Cord Medicine

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Background: Curcumin, a polyphenolic compound extracted from the plant turmeric, has protective effects on spinal cord injury (SCI) through attenuation of inflammatory response. This study was designed to detect whether curcumin modulates toll-like receptor 4 (TLR4) and the nuclear factor-kappa B (NF-κB) inflammatory signaling pathway in the injured rat spinal cord following SCI. Methods: Adult male Sprague-Dawley rats were subjected to laminectomy at T8-T9 and compression with a vascular clip. There were three groups: (a) sham group; (b) SCI group; and (g) SCI + curcumin group. We measured TLR4 gene and protein expression by real-time polymerase chain reaction and western blot analysis; NF-κB activity by electrophoretic mobility shift assay, inflammatory cytokines tumor necrosis factor-α, interleukin-1β, and interleukin-6 levels by enzyme-linked immunosorbent assay, hindlimb locomotion function by Basso, Beattie, and Bresnahan rating, spinal cord edema by wet/dry weight method, and apoptosis by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) analysis. Results:The results showed that SCI induced the up-regulation of TLR4, NF-κB, and inflammatory cytokines in the injured rat spinal cord. Treatment with curcumin following SCI markedly down-regulated the levels of these agents related to the TLR4/NF-κB inflammatory signaling pathway. Administration of curcumin also significantly ameliorated SCI induced hind limb locomotion deficits, spinal cord edema, and apoptosis. Conclusions: Post-SCI curcumin administration attenuates the TLR4/NF-κB inflammatory signaling pathway in the injured spinal cord, and this may be a mechanism whereby curcumin improves the outcome following SCI.

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Section: Discussionmentioning

confidence: 98%

Curcumin modulates TLR4/NF-κB inflammatory signaling pathway following traumatic spinal cord injury in rats

Jin

Zhu

et al. 2014

The Journal of Spinal Cord Medicine

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“…In contrast, defense mechanisms could be activated by moderately increased ROS through survival pathways, as demonstrated in vitro (Jia et al, 2008) and in an in vivo model of lung injury (e.g. anti-inflammatory effects) (Xiao et al, 2012). Cytoprotection is partly mediated by the nuclear factor (erythroid 2-related factor Nrf2) that controls the antioxidant response element (ARE)-dependent gene regulation in response to oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Relationship between severity of adult community-acquired pneumonia and impairment of the antioxidant defense system

Castillo

Carrasco

Álvarez³

et al. 2013

Biol. Res.

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Oxidant/antioxidant imbalance has been reported in some infectious diseases, including community-acquired pneumonia (CAP). The aim was to assess the antioxidant status in adults with CAP and its relationship with clinical severity at admission. Fifty-nine patients with CAP were enrolled and categorized at admission by the FINE score, from July 2010 to October 2012. In the same period 61 controls were enrolled. Plasma samples were obtained at admission for determination of the ferric reducing ability of plasma (FRAP) and lipid peroxidation (8-isoprostane). Erythrocyte reduced (GSH)/oxidized (GSSG) glutathione, malondialdehyde (MDA) and antioxidant enzyme activity were assessed. Antioxidant status in adults with CAP represented by FRAP and the GSH/GSSG ratio were 16.8% (p=0.03) and 39.7% (p=0.04) lower than control values, respectively. In addition, FRAP values showed a positive correlation with GSH/GSSG ratio (r=0.852; p<0.02; n=59). The CAP group showed greater lipid peroxidation in both plasma and erythrocytes. The FINE score correlated negatively with FRAP (r= -0.718; p<0.05; n=59) and positively with MDA and F2 isoprostane levels (r=0.673; p<0.05; n=59; r=0.892; p<0.01; n=59, respectively). Antioxidant status alterations correlated with clinical severity. The FRAP assay and lipid peroxidation biomarkers may provide a useful parameter for estimating the severity and the clinical outcome of patients with CAP.

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“…Hamdy et al, 2012;Nemmar et al, 2012;Suresh et al, 2012;Xiao et al, 2012;Avasarala et al, 2013;Cho et al, 2013)] resulted in pulmonary edema, alveolar wall thickening, inflammatory cell infiltration, and fibrosis. These symptoms were attenuated by curcumin (most often delivered orally) at doses typically in the region of 50 mg/kg, which would equate to a dosing regimen of approximately 3.5 g/d for a 70 kg human.…”

Section: Shishodia Et Al 2003mentioning

confidence: 99%

Translating Curcumin to the Clinic for Lung Cancer Prevention: Evaluation of the Preclinical Evidence for Its Utility in Primary, Secondary, and Tertiary Prevention Strategies

Howells

Mahale

Sale

et al. 2014

J Pharmacol Exp Ther

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Lung cancer is responsible for over one million deaths worldwide each year. Smoking cessation for lung cancer prevention remains key, but it is increasingly acknowledged that prevention strategies also need to focus on high-risk groups, including ex-smokers, and patients who have undergone resection of a primary tumor. Models for chemoprevention of lung cancer often present conflicting results, making rational design of lung cancer chemoprevention trials challenging. There has been much focus on use of dietary bioactive compounds in lung cancer prevention strategies, primarily due to their favorable toxicity profile and long history of use within the human populace. One such compound is curcumin, derived from the spice turmeric. This review summarizes and stratifies preclinical evidence for chemopreventive efficacy of curcumin in models of lung cancer, and adjudges the weight of evidence for use of curcumin in lung cancer chemoprevention strategies.

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Curcumin Protects Against Sepsis-Induced Acute Lung Injury in Rats

Cited by 89 publications

References 33 publications

Curcumin modulates TLR4/NF-κB inflammatory signaling pathway following traumatic spinal cord injury in rats

Curcumin modulates TLR4/NF-κB inflammatory signaling pathway following traumatic spinal cord injury in rats

Relationship between severity of adult community-acquired pneumonia and impairment of the antioxidant defense system

Translating Curcumin to the Clinic for Lung Cancer Prevention: Evaluation of the Preclinical Evidence for Its Utility in Primary, Secondary, and Tertiary Prevention Strategies

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