Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism

Liu, Zhaohui; Yu, Yi; Li, Xueping; Ross, Christopher A.; Smith, Wanli W.

doi:10.1016/j.phrs.2011.01.004

Cited by 129 publications

(79 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is in fact some evidence that a-synuclein overexpression can induce ROS, and that suppressing these through molecular or pharmacological means may be neuroprotective in mammalian (Hsu et al 2000;Clark et al 2010;Liu et al 2011) or insect systems (Wassef et al 2007;Botella et al 2008). …”

Section: A-synuclein At the Mitochondria And Relationship To Oxidativmentioning

confidence: 99%

-Synuclein in Parkinson's Disease

Stefanis¹

2011

Cold Spring Harbor Perspectives in Medicine

1,076

732

View full text Add to dashboard Cite

Section: A-synuclein At the Mitochondria And Relationship To Oxidativmentioning

confidence: 99%

-Synuclein in Parkinson's Disease

Stefanis¹

2011

Cold Spring Harbor Perspectives in Medicine

1,076

732

View full text Add to dashboard Cite

“…Benefi cial protection of axons from degeneration by suppressing the local neuroinfl ammation is also a ribu ed to curcumin (14). Curcumin rescued α-synuclein-induced cell death (15). By targeting histone deacetylase (HDAC), curcumin promisingly prevented apoptosis and improved motor defi cits in Parkinson's disease (PD) in rat model (16,17).…”

Section: Introductionmentioning

confidence: 99%

Curcumin-Protected PC12 Cells Against Glutamate-Induced Oxidative Toxicity

Chang

Chen

Yü

et al. 2014

Food. Technol. Biotechnol.

View full text Add to dashboard Cite

SummaryGlutamate is a major excitatory neurotransmi er present in the central nervous system. The glutamate/cystine antiporter system x c -connects the antioxidant defense with neurotransmission and behaviour. Overactivation of ionotropic glutamate receptors induces neuronal death, a pathway called excitotoxicity. Glutamate-induced oxidative stress is a major contributor to neurodegenerative diseases including cerebral ischemia, Alzheimer's and Huntington's disease. Curcuma has a wide spectrum of biological activities regarding neuroprotection and neurocognition. By reducing the oxidative damage, curcumin a enuates a spinal cord ischemia-reperfusion injury, seizures and hippocampal neuronal loss. The rat pheochromocytoma (PC12) cell line exhibits many characteristics useful for the study of the neuroprotection and neurocognition. This investigation was carried out to determine whether the neuroprotective eff ects of curcumin can be observed via the glutamate-PC12 cell model. Results indicate that glutamate (20 mM) upregulated glutathione peroxidase 1, glutathione disulphide, Ca 2+ infl ux, nitric oxide production, cytochrome c release, Bax/Bcl-2 ratio, caspase-3 activity, lactate dehydrogenase release, reactive oxygen species, H 2 O 2 , and malondialdehyde; and downregulated glutathione, glutathione reductase, superoxide dismutase and catalase, resulting in enhanced cell apoptosis. Curcumin alleviates all these adverse eff ects. Conclusively, curcumin can eff ectively protect PC12 cells against the glutamate-induced oxidative toxicity. Its mode of action involves two pathways: the glutathione-dependent nitric oxide-reactive oxygen species pathway and the mitochondria-dependent nitric oxide-reactive oxygen species pathway.

show abstract

“…14 Furthermore, Liu et al have shown that curcumin protects against A53T a-synuclein-induced toxicity in a PC12-inducible cell model for PD. 15 Lee et al have revealed that curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in Drosophila melanogaster. Park et al [15][16][17] have shown that curcumin improves mobility defects of Drosophila exposed to acute PQ toxicity.…”

mentioning

confidence: 99%

“…15 Lee et al have revealed that curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in Drosophila melanogaster. Park et al [15][16][17] have shown that curcumin improves mobility defects of Drosophila exposed to acute PQ toxicity. All of these studies highlight the efficacy of the curcumin as a therapeutic agent in mitigating the burden of PD.…”

mentioning

confidence: 99%

Curcumin's Neuroprotective Efficacy in Drosophila Model of Idiopathic Parkinson's Disease Is Phase Specific: Implication of its Therapeutic Effectiveness

Phom

Achumi

Alone

et al. 2014

Rejuvenation Research

View full text Add to dashboard Cite

Selective degeneration of dopaminergic neurons in the substantia nigra underlies the basic motor impairments of Parkinson's disease (PD). Curcumin has been used for centuries in traditional medicines in India. Our aim is to understand the efficacy of genotropic drug curcumin as a neuroprotective agent in PD. Analysis of different developmental stages in model organisms revealed that they are characterized by different patterns of gene expression which is similar to that of developmental stages of human. Genotropic drugs would be effective only during those life cycle stages for which their target molecules are available. Hence there exists a possibility that targets of genotropic compounds such as curcumin may not be present in all life stages. However, no reports are available in PD models illustrating the efficacy of curcumin in later phases of adult life. This is important because this is the period during which late-onset disorders such as idiopathic PD set in. To understand this paradigm, we tested the protective efficacy of curcumin in different growth stages (early, late health stage, and transition phase) in adult Drosophila flies. Results showed that it can rescue the motor defects during early stages of life but is ineffective at later phases. This observation was substantiated with the finding that curcumin treatment could replenish depleted brain dopamine levels in the PD model only during early stages of life cycle, clearly suggesting its limitation as a therapeutic agent in late-onset neurodegenerative disorders such as PD.

show abstract

Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism

Cited by 129 publications

References 58 publications

-Synuclein in Parkinson's Disease

-Synuclein in Parkinson's Disease

Curcumin-Protected PC12 Cells Against Glutamate-Induced Oxidative Toxicity

Curcumin's Neuroprotective Efficacy in Drosophila Model of Idiopathic Parkinson's Disease Is Phase Specific: Implication of its Therapeutic Effectiveness

Contact Info

Product

Resources

About