Curcumin promotes degradation of inducible nitric oxide synthase and suppresses its enzyme activity in RAW 264.7 cells

Diethylcarbamazine inhibits NF-κB activation in acute lung injury induced by carrageenan in mice

“…This reduction could be attributed to the inhibition of iNOS expression in lung tissue or due to iNOS regulation by transcription factors such as NF-κB. Studies show that curcumin inhibits the expression of iNOS and NO production by direct interference in the NF-κB pathway [26,27]. Our results show that treatment with the inhibitor (CUR) was also able to reduce NO production and iNOS expression of the enzyme in close proximity to the effect produced by DEC. Fig.…”

Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives

“…[1][2][3][4][5][6][7] Curcumin has been reported to exhibit incredible antioxidant, anti-inflammatory and anti-cancer properties upon their excellent superoxide and free radical inhibition, pro-inflammatory cytokines and enzymes suppression, and cancer cells apoptosis induction. [8][9][10][11] Curcumin has also been shown to acts as antibacterial and anti-malarial agents based on its cytotoxic effect on several bacteria and parasites, such as Helicobacter pylori and Plasmodium falciparum. 12,13 However, the practical use of curcumin is limited by its poor absorbability and stability, resulting in low oral bioavailability, which therefore diminishes its usefulness in clinical trials.…”

Enzyme Prodrug Therapy Engineered into Biomaterials

“…[ 17 ] In contrast, advanced possibilities such as pulsatile release or release on demand at specifi ed time points are signifi cantly harder to accomplish and successes in these undertaking are few. Biomedical relevance activities via in the inhibition of production of NO through the degradation of iNOS, [ 66 ] whereas dexamethasone reduces the translation of iNOS mRNA. On-demand release of two and more drugs with their respective and independently nominated times of release would require two orthogonal mechanisms of stimuli response to be engineered into the same biomaterial, and to the best of our knowledge, such design has never been accomplished.…”