Curcumin promotes browning of white adipose tissue in a norepinephrine-dependent way

Wang, Shan; Wang, Xiuchao; Ye, Zichen; Xu, Chunsheng; Zhang, Ming; Ruan, Banjun; Wei, Ming; Jiang, Yinghao; Zhang, Ying; Wang, Li; Li, Xiaoying; Lu, Zifan

doi:10.1016/j.bbrc.2015.09.018

Cited by 120 publications

(100 citation statements)

References 36 publications

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“…These properties have been heavily assessed for exploring its potential utilization in cancer treatment [28,29] . In addition, a few recent studies have reported the potential effect of curcumin in promoting white adipocyte "browning" [30,31] .…”

Section: Dietary Polyphenol and Dietary Polyphenol Interventionmentioning

confidence: 99%

“…The insulin signaling improvement effect of curcumin (and possibly other dietary polyphenols) can be attributed, in the long term, to its anti-inflammation, anti-oxidation and body weight lowering effects. The body weight lowering effect of this compound can be attributed to not only the attenuation of adipose tissue macrophage infiltration [20] but also to its potential adipocyte "browning" effect, leading to an increase in energy expenditure [30] . As illustrated in Figure 2, we have demonstrated that Fgf21 and ChREBP are two novel hepatic targets of curcumin; both of them are known as positive regulators of hepatic insulin signaling.…”

Section: Summary and Perspectivesmentioning

confidence: 99%

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Curcumin and dietary polyphenol research: beyond drug discovery

Jin

2018

Acta Pharmacol Sin

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Numerous natural products available over the counter are commonly consumed by healthy, sub-healthy or ill people for the treatment and prevention of various chronic diseases. Among them, a few dietary polyphenols, including the curry compound curcumin, have been attracting the most attention from biomedical researchers and drug developers. Unlike many so-called "good drug candidates", curcumin and several other dietary polyphenols do not have a single known therapeutic target or defined receptor. In addition, the bioavailability of these polyphenols is usually very low due to their poor absorption in the gut. These recently debated features have created enormous difficulties for drug developers. In this review, I do not discuss how to develop curcumin, other dietary polyphenols or their derivatives into pharmaceutical agents. Instead, I comment on how curcumin and dietary polyphenol research has enriched our knowledge of insulin signaling, including the presentation of my perspectives on how these studies will add to our understanding of the famous hepatic insulin function paradox.

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Section: Dietary Polyphenol and Dietary Polyphenol Interventionmentioning

confidence: 99%

Section: Summary and Perspectivesmentioning

confidence: 99%

Curcumin and dietary polyphenol research: beyond drug discovery

Jin

2018

Acta Pharmacol Sin

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“…The curry spice curcumin has been extensively studied in animal models to reduce amyloid pathology with bene icial effects on the prevention of neurodegeneration in man. Curcumin ( Figure 1) has been used in various studies to inhibit adipogenesis and decrease adipose tissue mass [30][31][32][33]. In the liver curcumin has been shown to stabilize or reverse NAFLD [34][35][36] but in speci ic controls curcumin has been shown to increase liver enzymes in short term studies.…”

Section: Editorialmentioning

confidence: 99%

Indian spices and Caffeine treatment for Obesity and Cardiovascular disease

Martins¹

2017

Ann Clin Endocrinol Metabol

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“…And however, there is little evidence to show that curcumin induces the formation of brown-like adipocytes and the molecular mechanisms involved remain elusive. In addition, in most experimental trials, high doses of curcumin are administered [43]. Curcumin can potentially prevent obesity by inducing browning of inguinal WAT via the norepinephrine-β3AR pathway.…”

Section: Liu Et Al Have Found Thatmentioning

confidence: 99%

Untitled

2018

RJLBPCS

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ABSTRACT:In recent years there has been growing interest in the ability of phytochemicals which are biologically active to prevent chronic diseases such as cancer. Phytochemicals have been found to modulate the expression or activity of a large number of cellular proteins which are key for cell survival and the transformed phenotype. In this review we have attempted to address this concern to optimize the design of chemo preventive treatment by using nanocurcumin. It is important to determine which of the many reported mechanisms of action are chemically relevant. In this we consider the structure mechanisms, limitations of curcumin of a phytochemical which has very much potential against cancer. In this review we also consider the in vitro studies have provided useful insight into their mechanisms of action in humans. Curcumin can also sensitize tumors to chemotherapy and radiation. Clinical trial suggests that curcumin has activity against human head squamous cell carcinoma (HNSCC), colorectal cancer, hepatic cancer, oral cancer, mantle cell lymphoma and other various type of cancer. This review discusses the preventive and therapeutic potential of curcumin against cancer. Studies in humans reveal that oral administration of curcumin furnishes very low systemic levels of curcumin mostly in the low nanomolar range, so in this review study we also concentrated nanoparticle encapsulated curcumin may provide an alternative means to increase the bioavailability and also enhance the efficacy of its therapeutic effect.

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Curcumin promotes browning of white adipose tissue in a norepinephrine-dependent way

Cited by 120 publications

References 36 publications

Curcumin and dietary polyphenol research: beyond drug discovery

Curcumin and dietary polyphenol research: beyond drug discovery

Indian spices and Caffeine treatment for Obesity and Cardiovascular disease

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