Curcumin prevents proteins expression changes of oxidative phosphorylation, cellular stress response, and lipid metabolism proteins in liver of mice fed a high-fructose diet

Silva-Gaona, Oscar Gerardo; Hernández‐Ortíz, Magdalena; Vargas-Ortiz, Katya; Ramı́rez-Emiliano, Joel; Garay‐Sevilla, Ma. Eugenia; Encarnación‐Guevara, Sergio; Pérez-Vázquez, Victoriano

doi:10.1016/j.jprot.2022.104595

Cited by 5 publications

(5 citation statements)

References 43 publications

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“…The observed effect of CMN can be further supported by a significant increase in CCO reactivity in the secretory epithelium, which was highest in the group treated with both PTU and CMN. Other studies have suggested that CMN may increase the expression of proteins involved in oxidative phosphorylation in the liver of mice on a high-fructose diet [43]. Our previous study indicated that CMN did not improve thyroid function in aged male rats (18-month-old) with reduced production of thyroid hormones in comparison to 3-month-old ones [16].…”

Section: Discussionmentioning

confidence: 72%

Curcumin exerts protective effects on the thyroid gland in propylthiouracil-treated rats

Papież

2023

Folia Histochem Cytobiol.

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This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially. www.journals.viamedica.pl/folia_histochemica_cytobiologica ©Polish Society for Histochemistry and Cytochemistry

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Section: Discussionmentioning

confidence: 72%

Curcumin exerts protective effects on the thyroid gland in propylthiouracil-treated rats

Papież

2023

Folia Histochem Cytobiol.

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“…We can associate these genes with broad mechanisms connected to skin disorders. Lipid metabolism and sebum production: The genes FADS2, SOAT1, TECR and APOC1 may play a significant role in regulating skin lipid metabolism, sebum production and composition, potentially contributing to skin conditions such as folliculitis and skin fibrosis 92 Cellular energy metabolism and oxidative stress: PHB2 and THRSP, involved in skin cell energy metabolism and oxidative stress response, could be connected with skin disorders such as fibrosarcoma and congenital ichthyosis 93,94 Cholesterol synthesis and skin barrier function: Genes such as DHCR7 and TKT could participate in cholesterol synthesis and the regulation of skin barrier function, potentially associated with genetic skin diseases like Smith‐Lemli‐Opitz syndrome and keratinization disorders. …”

Section: Resultsmentioning

confidence: 99%

“…92 • Cellular energy metabolism and oxidative stress: PHB2 and THRSP, involved in skin cell energy metabolism and oxidative stress response, could be connected with skin disorders such as fibrosarcoma and congenital ichthyosis. 93,94 • Cholesterol synthesis and skin barrier function: Genes such as DHCR7 and TKT could participate in cholesterol synthesis and the regulation of skin barrier function, potentially associated with genetic skin diseases like Smith-Lemli-Opitz syndrome and keratinization disorders.…”

Section: Mclustermentioning

confidence: 99%

Comprehensive modular analyses of scar subtypes illuminate underlying molecular mechanisms and potential therapeutic targets

Liu,

Lu,

Qiu

et al. 2023

International Wound Journal

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Pathological scarring resulting from traumas and wounds, such as hypertrophic scars and keloids, pose significant aesthetic, functional and psychological challenges. This study provides a comprehensive transcriptomic analysis of these conditions, aiming to illuminate underlying molecular mechanisms and potential therapeutic targets. We employed a co‐expression and module analysis tool to identify significant gene clusters associated with distinct pathophysiological processes and mechanisms, notably lipid metabolism, sebum production, cellular energy metabolism and skin barrier function. This examination yielded critical insights into several skin conditions including folliculitis, skin fibrosis, fibrosarcoma and congenital ichthyosis. Particular attention was paid to Module Cluster (MCluster) 3, encompassing genes like BLK, TRPV1 and GABRD, all displaying high expression and potential implications in immune modulation. Preliminary immunohistochemistry validation supported these findings, showing elevated expression of these genes in non‐fibrotic samples rich in immune activity. The complex interplay of different cell types in scar formation, such as fibroblasts, myofibroblasts, keratinocytes and mast cells, was also explored, revealing promising therapeutic strategies. This study underscores the promise of targeted gene therapy for pathological scars, paving the way for more personalised therapeutic approaches. The results necessitate further research to fully ascertain the roles of these identified genes and pathways in skin disease pathogenesis and potential therapeutics. Nonetheless, our work forms a strong foundation for a new era of personalised medicine for patients suffering from pathological scarring.

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“…NDFUAF7 is essential for complex I assembly and early vertebrate embryogenesis ( 71 ), and it seems relevant in our experimental design, being upregulated in DistUt and ProxUt, as well as UTJ and Isth. In addition, the antioxidant curcumin, administrated orally in mice, can increase the abundance of several proteins, including the ones involved in protein phosphorylation, namely, NDUFB3, NDUFAB1, and NDUFA7 ( 72 ). Our results showed a significant decrease of these three genes in the Inf, suggesting the necessity of a controlled downregulation in this specific tissue may be related to the soon reception of the oocyte; however, further mechanistic studies are needed.…”

Section: Discussionmentioning

confidence: 99%

Mating modifies the expression of crucial oxidative-reductive transcripts in the pig oviductal sperm reservoir: is the female ensuring sperm survival?

et al. 2023

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BackgroundMating induces large changes in the female genital tract, warranting female homeostasis and immune preparation for pregnancy, including the preservation of crucial oxidative status among its pathways. Being highly susceptible to oxidative stress, sperm survival and preserved function depend on the seminal plasma, a protection that is removed during sperm handling but also after mating when spermatozoa enter the oviduct. Therefore, it is pertinent to consider that the female sperm reservoir takes up this protection, providing a suitable environment for sperm viability. These aspects have not been explored despite the increasing strategies in modulating the female status through diet control and nutritional supplementation.AimsTo test the hypothesis that mating modifies the expression of crucial oxidative-reductive transcripts across the entire pig female genital tract (cervix to infundibulum) and, particularly in the sperm reservoir at the utero-tubal junction, before ovulation, a period dominated by estrogen stimulation of ovarian as well as of seminal origin.MethodsThe differential expression of estrogen (ER) and progesterone (PR) receptors and of 59 oxidative-reductive transcripts were studied using a species-specific microarray platform, in specific segments of the peri-ovulatory sow reproductive tract in response to mating.ResultsMating induced changes along the entire tract, with a conspicuous downregulation of both ER and PR and an upregulation of superoxide dismutase 1 (SOD1), glutaredoxin (GLRX3), and peroxiredoxin 1 and 3 (PRDX1, PRDX3), among other NADH Dehydrogenase Ubiquinone Flavoproteins, in the distal uterus segment. These changes perhaps helped prevent oxidative stress in the area adjacent to the sperm reservoir at the utero-tubal junction. Concomitantly, there were a downregulation of catalase (CAT) and NADH dehydrogenase (ubiquinone) oxidoreductases 1 beta subcomplex, subunit 1 (NDUFB1) in the utero-tubal junction alongside an overall downregulation of CAT, SOD1, and PRDX3 in the ampullar and infundibulum segments.ConclusionsNatural mating is an inducer of changes in the expression of female genes commanding antioxidant enzymes relevant for sperm survival during sperm transport, under predominant estrogen influence through the bloodstream and semen. The findings could contribute to the design of new therapeutics for the female to improve oxidative-reductive balance.

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Curcumin prevents proteins expression changes of oxidative phosphorylation, cellular stress response, and lipid metabolism proteins in liver of mice fed a high-fructose diet

Cited by 5 publications

References 43 publications

Curcumin exerts protective effects on the thyroid gland in propylthiouracil-treated rats

Curcumin exerts protective effects on the thyroid gland in propylthiouracil-treated rats

Comprehensive modular analyses of scar subtypes illuminate underlying molecular mechanisms and potential therapeutic targets

Mating modifies the expression of crucial oxidative-reductive transcripts in the pig oviductal sperm reservoir: is the female ensuring sperm survival?

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