Curcumin/poly(2-methyl-2-oxazoline-b-tetrahydrofuran-b-2-methyl-2-oxazoline) formulation: An improved penetration and biological effect of curcumin in F508del-CFTR cell lines

Gonçalves, Cristine; Gomez, Jean-Pierre; Même, William; Rasolonjatovo, Bazoly; Gosset, David; Nédellec, Steven; Hulin, Philippe; Huin, Cécile; Gall, Tony Le; Montier, Tristan; Lehn, Pierre; Pichon, Chantal; Guégan, Philippe; Cheradame, Hervé; Midoux, Patrick

doi:10.1016/j.ejpb.2017.04.015

Cited by 13 publications

(7 citation statements)

References 73 publications

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“…Their apoptotic, autophagic, anti-inflammatory effects and maintaining redox balance make them promising anti breast cancer agents (Losada-Echeberria et al 2017). Curcumin, genistein, quercetin, resveratrol and silibinin are reported to have great potential against breast cancer (Goncalves et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Effects of somatostatin, curcumin, and quercetin on the fatty acid profile of breast cancer cell membranes

Hanikoğlu

Kucuksayan

Hanikoglu

et al. 2020

Can. J. Physiol. Pharmacol.

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Breast cancer is a worldwide commonly found malignancy in women and effective treatment is regarded as a huge clinical challenge even in the presence of several treatment options. Extensive literature is available demonstrating polyphenols as phytopharmaceutical anticancer agents. Among the polyphenols, quercetin and curcumin have been reported to have a strong potential against breast cancer. However, so far, no comprehensive study has been performed to demonstrate the anticarcinogenic effects of curcumin, quercetin, and their combinations with somatostatin on the fatty acid profile of breast cancer cell membranes. We used MCF-7 and MDA-MB231 breast cancer cells incubated with curcumin and quercetin for 24 h, in the absence and presence of somatostatin, at their EC50 concentrations to evaluate membrane fatty acid based functional lipidomics together with the followup of EGFR and MAPK signaling pathways. The two cell lines gave different membrane free fatty acid reorganization. In MCF-7 cells, the following changes were observed: an increase of ω6 linoleic acid in the cells incubated with somatostatin + quercetin and quercetin and a decrease of ω3 acids in the cells incubated with somatostatin + curcumin compared to somatostatin and significant increases of monounsaturated fatty acid (MUFA), mono-trans arachidonic acid levels and docosapentaenoic acid for the cells incubated with somatostatin + quercetin compared to the control cells. In MDA-MB231 cells, incubations with curcumin, quercetin, and somatostatin + quercetin induced the most significant membrane remodeling with the increase of stearic acid, diminution of ω6 linoleic, arachidonic acids, and ω3 (docosapentaenoic and docosahexaenoic acids). Distinct signaling pathway changes were found for these cell lines. In MCF-7 cells, separate or combined incubations with somatostatin and quercetin, significantly decreased EGFR and incubation with curcumin decreased MAPK signaling. In MDA-MB231 cells, incubation with curcumin decreased AKT1 and p-AKT1 (Thr308) levels. Incubation with curcumin and quercetin decreased the EGFR levels. Our results showed that cytostatic and antioxidant treatments can be combined to induce membrane fatty acid changes, including lipid isomerization as specific free radical driven process, and to influence signaling pathways. This study aimed to contribute to the literature on these antioxidants in the treatment of breast cancer to clarify the effects and mechanisms in combination with somatostatin.

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Section: Introductionmentioning

confidence: 99%

Effects of somatostatin, curcumin, and quercetin on the fatty acid profile of breast cancer cell membranes

Hanikoğlu

Kucuksayan

Hanikoglu

et al. 2020

Can. J. Physiol. Pharmacol.

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“…It can be interpreted that an increase in the chroma values indicates the conversion of curcumin from its keto to enol form. Yet, a less positive value was observed for the 0.1% TP at 5% SB (Figure d–f); the concentration of curcumin at a high level of SB increases the darkness of the sample and gives a higher redness value …”

Section: Results and Discussionmentioning

confidence: 91%

4D Printing of Sago Starch with Turmeric Blends: A Study on pH-Triggered Spontaneous Color Transformation

Shanthamma

Preethi

Moses

et al. 2021

ACS Food Sci. Technol.

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In recent years, the demand for customized products is on the rise, and 3D printing is emerging as a disruptive technology with the potential to revolutionize food manufacturing processes. Among the various facets of 4D printing, the color transformation of 3D-printed constructs in response to external stimuli is a field of growing research interest, particularly because the color of a food product is a key attribute that decides consumer preferences. In this study, turmeric powder was incorporated into sago flour at various levels (0, 0.5, 1.5, 2.5% w/w) and used as the 3D printing material supply. They were extrusion-printed in the in-house-developed food printer CARK (optimized at a printing speed of 2000 mm/min, with the pressure of 3 bar and nozzle diameter of 0.84 mm) and then immersed in solutions with varying concentrations of sodium bicarbonate (1, 3, and 5% w/w). The concentration and time-dependent shift in color from yellow to orange-red of the 3D constructs were evaluated, and the conditions were optimized considering sensory scores. This study provides insights into the development of a novel range of curcumin-based 4D-printed foods with color transformation capabilities.

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“…Still on this note, the very hydrophobic nature and low stability in water of compounds, such as curcumin, is a major drawback in their clinical application. In a very recent work, Gonçalves et al 69 showed that the neutral amphiphilic triblock copolymer MeOx6-THF19-MeOx6 (TBCP2) can solubilize curcumin and facilitate its penetration in Phe508del CFTR human airway epithelial cells, enhancing curcumin potentiation of CFTR mediate Cl-selective currents in these cells. These data suggests that TBCP2 may constitute a helpful tool for the delivery of this and other highly insoluble therapeutic drugs to CF patients.…”

Section: Aonmentioning

confidence: 99%

Combination therapy in Phe508del CFTR: how many will be enough?

Matos¹,

Matos²

2018

J Lung Health Dis

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Cystic fibrosis (CF) is a complex inherited disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene 1 . Around 2000 disease causing mutations are known for this gene, which encodes a Chloride (Cl−) channel expressed at the plasma membrane (PM) of epithelial cells 1,2 . Clinically the disease affects mostly the respiratory tract, where obstruction of the airways by thick mucus leads to: bacterial infections, extensive lung damage, and eventually, respiratory failure. Other affected systems include the gastrointestinal and reproductive tracts and endocrine system. Thus, the severity of symptoms can differ widely within individuals depending on their mutations, environment and biometrical characteristics. These variables modify the clinical course of the disease and each patient response to therapy 3,4 .

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Curcumin/poly(2-methyl-2-oxazoline-b-tetrahydrofuran-b-2-methyl-2-oxazoline) formulation: An improved penetration and biological effect of curcumin in F508del-CFTR cell lines

Cited by 13 publications

References 73 publications

Effects of somatostatin, curcumin, and quercetin on the fatty acid profile of breast cancer cell membranes

Effects of somatostatin, curcumin, and quercetin on the fatty acid profile of breast cancer cell membranes

4D Printing of Sago Starch with Turmeric Blends: A Study on pH-Triggered Spontaneous Color Transformation

Combination therapy in Phe508del CFTR: how many will be enough?

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