Curcumin‐piperine co‐supplementation and human health: A comprehensive review of preclinical and clinical studies

Heidari, Hajar; Bagherniya, Mohammad; Majeed, Muhammed; Sathyapalan, Thozhukat; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

doi:10.1002/ptr.7737

Cited by 57 publications

(15 citation statements)

References 125 publications

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“…41 Curcumin has been shown to have antibacterial properties since 1949, 42 and other studies have established its numerous pharmacological effects including anti-inflammatory, anticancer, anti-oxidant, wound-healing, and anti-viral activities, all of which are thought to have therapeutic benefits for a number of human-related ailments. [43][44][45][46][47][48][49][50][51][52][53][54] In vitro, curcumin inhibits many enzymes, including cyclooxygenase and the sarcoplasmic/reticulum calcium pump (SERCA). [55][56][57][58][59][60] The mechanisms of action associated with the use of curcumin in CF patients are depicted in Figure 5.…”

Section: Curcuminmentioning

confidence: 99%

“…Secondary metabolites of this component include phenolic acids, flavonoids, alkaloids, terpenoids, tannins, and saponins, each of which has been proven to have biological activity 41 . Curcumin has been shown to have antibacterial properties since 1949, 42 and other studies have established its numerous pharmacological effects including anti‐inflammatory, anticancer, anti‐oxidant, wound‐healing, and anti‐viral activities, all of which are thought to have therapeutic benefits for a number of human‐related ailments 43–54 . In vitro, curcumin inhibits many enzymes, including cyclooxygenase and the sarcoplasmic/reticulum calcium pump (SERCA) 55–60 .…”

Section: Herbal Medicinementioning

confidence: 99%

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Therapeutic potential of phytochemicals for cystic fibrosis

et al. 2023

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The aim of this review was to review and discuss various phytochemicals that exhibit beneficial effects on mutated membrane channels, and hence, improve transmembrane conductance. These therapeutic phytochemicals may have the potential to decrease mortality and morbidity of CF patients. Four databases were searched using keywords. Relevant studies were identified, and related articles were separated. Google Scholar, as well as gray literature (i.e., information that is not produced by commercial publishers), were also checked for related articles to locate/identify additional studies. The relevant databases were searched a second time to ensure that recent studies were included. In conclusion, while curcumin, genistein, and resveratrol have demonstrated effectiveness in this regard, it should be emphasized that coumarins, quercetin, and other herbal medicines also have beneficial effects on transporter function, transmembrane conductivity, and overall channel activity. Additional in vitro and in vivo studies should be conducted on mutant CFTR to unequivocally define the mechanism by which phytochemicals alter transmembrane channel function/activity, since the results of the studies evaluated in this review have a high degree of heterogenicity and discrepancy. Finally, continued research be undertaken to clearly define the mechanism(s) of action and the therapeutic effects that therapeutic phytochemicals have on the symptoms observed in CF patients in an effort to reduce mortality and morbidity.

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Section: Curcuminmentioning

confidence: 99%

Section: Herbal Medicinementioning

confidence: 99%

Therapeutic potential of phytochemicals for cystic fibrosis

et al. 2023

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“…[15][16][17][18] Literature reviews have shown that, synergistic effect between piperine and curcumin, increasing the bioavailability of curcumin. [19,20] Additionally, recent reports also indicated that nanoparticles and piperine-loaded nanoparticles enhance the bioavailability of curcumin. [21,22] In research studies, curcumin derivatives are typically synthesized, and these synthetic derivatives, especially enone and dienone curcumin derivatives, have been noted for their superior antiangiogenic effects compared to curcumin.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, it has been demonstrated to possess a ′bioenhancer′ character [15–18] . Literature reviews have shown that, synergistic effect between piperine and curcumin, increasing the bioavailability of curcumin [19,20] . Additionally, recent reports also indicated that nanoparticles and piperine‐loaded nanoparticles enhance the bioavailability of curcumin [21,22] …”

Section: Introductionmentioning

confidence: 99%

Microbial Transformation of Curcumin and Synergistic Investigation of Its Derivatives with Piperine

Yetim,

Özşen Batur

2024

ChemistrySelect

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Curcumin is associated with a wide range of pharmacological properties for the prevention and treatment of a wide spectrum of diseases. The clinical use of curcumin is limited due to its poor bioavailability. New methods were tried to overcome its limited utility, and one of these is the synthesis of new derivatives. Additionally adjunct compounds are used to enhance the bioavailability of curcumin. In order to improve its bioavailability, different formulation techniques such as co‐administration with piperine and nanoparticles are among the aids. Within the scope of this study, it is aimed to obtain curcumin derivatives by microbial transformation and to reveal their biological activities. Initially 25 different microbial strains were used for biotransformation experiments. Among the evaluated, Alternaria alternata converted three metabolites; namely, hexahydrocurcumin, demethoxyoctahydrocurcumin, octahydrocurcumin, were obtained with yields of 6.9 %, 2.6 % and 5.9 %, respectively. The derivatives were tested against various bacteria using the broth microdilution method, however no remarkable activity was observed (MIC>250 μg/ml). Thus, combination of piperine was evaulated on the bioavailability of curcumin derivatives. As a result, it was noted that the activities of metabolites, individually with piperine, were higher compared to the synergistic effect demonstrated by curcumin‐piperine against bacteria for the first time.

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“…In addition, the anti‐diabetic and anti‐lipidemic effects of this polyphenol have previously been confirmed (Ganji et al, 2021; Mahdavi et al, 2020; Mahdavi, Bagherniya, et al, 2021; Mahdavi, Moradi, et al, 2021; Parsamanesh et al, 2018; Rafiee et al, 2021; Talebi et al, 2020). This phytochemical also has healing effects in many liver‐related diseases, including non‐alcoholic fatty liver disease (NAFLD), hepatic steatosis, and liver fibrosis (Bagherniya et al, 2018; Dadkhah Tehrani et al, 2023; Farzaei et al, 2018; Feng et al, 2019; Hassanizadeh et al, 2023; Heidari et al, 2023; Jalali et al, 2020; Lee et al, 2019; Sharifi et al, 2023; Wu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

The effect of medicinal plants on cirrhosis: A systematic review of clinical trials

Amini

Bagherniya

Butler

et al. 2023

Phytotherapy Research

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Medicinal plants with minimal side effects, low cost, and liver-protective effects can be a suitable treatment option for cirrhosis. Therefore, this systematic review aimed to determine the effectiveness of herbal medicines on cirrhosis, a life-threatening liver disease. PubMed, Scopus, Web of Science, and Google Scholar were systematically searched for clinical trials that investigated the effect of medicinal plants on cirrhosis. This review includes 11 clinical trials, of which eight studies including 613 patients assessed the effect of silymarin on cirrhosis. Three of six studies showed the beneficial effects of silymarin on aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Two studies including 118 patients investigated the effect of curcumin on cirrhosis, one showing improvement in quality of life and the other showing improvements in alkaline phosphatase (ALP), bilirubin, prothrombin time (PT), and the international normalized ratio (INR). An article including four patients investigated the effect of ginseng on cirrhosis; two patients reported improvement in the Child-Pugh score, and ascites decreased in two. All studies included here reported no or negligible side effects. Results showed that medicinal plants including silymarin, curcumin, and ginseng have beneficial effects on cirrhosis.However, due to the limited number of studies, further high-quality studies are warranted.

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Curcumin‐piperine co‐supplementation and human health: A comprehensive review of preclinical and clinical studies

Cited by 57 publications

References 125 publications

Therapeutic potential of phytochemicals for cystic fibrosis

Therapeutic potential of phytochemicals for cystic fibrosis

Microbial Transformation of Curcumin and Synergistic Investigation of Its Derivatives with Piperine

The effect of medicinal plants on cirrhosis: A systematic review of clinical trials

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