Curcumin Nutrition for the Prevention of Mesenteric Ischemia–Reperfusion Injury: An Experimental Rodent Model

Karatepe, Oğuzhan; Gülçiçek, Osman Bilgin; Uğurlucan, Murat; Adaş, Gökhan; Battal, Muharrem; As, Kemik; Kamali, Gulcin; Altuğ, Tuncay; Karahan, Servet

doi:10.1016/j.transproceed.2009.08.002

Cited by 27 publications

(31 citation statements)

References 23 publications

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“…[36] Tissue MPO levels have been reported to be decreased with curcumin therapy in ischemia/reperfusionand amiodarone-induced pulmonary fibrosis models. [37,38] In the present study, hepatic and renal tissue MPO levels were significantly higher in the sepsis group as compared to the control group (p<0.001 and p<0.01, respectively). MPO levels were significantly decreased in the sepsis group treated with curcumin as compared to the sepsis group (p<0.01 and p<0.05, respectively).…”

Section: Discussionsupporting

confidence: 44%

Antioxidant and Anti-inflammatory Effects of Curcumin Against Hepatorenal Oxidative Injury in the Experimental Sepsis Model Created in Rats

Savcun

Özkan

Dulundu

et al. 2013

Ulus Travma Acil Cerrahi Derg

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Section: Discussionsupporting

confidence: 44%

Antioxidant and Anti-inflammatory Effects of Curcumin Against Hepatorenal Oxidative Injury in the Experimental Sepsis Model Created in Rats

Savcun

Özkan

Dulundu

et al. 2013

Ulus Travma Acil Cerrahi Derg

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“…Modulation of infl ammatory response following I/R injury is an important component of tissue defense, mostly because infl ammation is the major component of cell death. Similarly, Karatepe et al (14) reported that curcumin pretreatment reduced the histopathologic indices of intestinal mucosal injury caused by mesenteric I/R. The investigators also reported that addition of curcumin to nutritional supplements reduced I/R injury through a mechanism suppressing the oxidative stress.…”

Section: Discussionmentioning

confidence: 91%

“…Recently, it has been reported that curcumin administration ameliorated I/R injury in rat kidney, myocardium, and nervous tissue (13). Curcumin treatment has been recently shown to attenuate reperfusion injury in a superior mesenteric artery I/R model in rats (14).…”

mentioning

confidence: 99%

Role of curcumin in mesenteric ischemia – reperfusion injury in rats

Okudan²,

Belviranlı³

et al. 2012

BLL

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Abstract:Background: Curcumin is an antioxidant molecule that has been shown to attenuate ischemia/reperfusion (I/R) injury in several organ systems. In the present study, we aimed to evaluate the possible effects of curcumin on contractile response to agonists and histopathological alterations in rat esophagus subjected to mesenteric I/R. Materials and methods: Adult male Wistar albino rats were randomly allocated to 4 groups, namely group I: sham-operated animals (n=10); group II: animals subdued to I/R injury only (n=10) and laparotomy; 45 minutes of superior mesenteric artery ligation were followed by 2 hours of reperfusion, group III: curcumin/sham (n=10); 20 days before I/R, curcumin (200 mg/kg/) was administered by gastric gavage, and group IV: curcumin-I/R (n=10). Mesenteric ischemia/reperfusion model was generated by clamping the superior mesenteric artery for 45 min followed by reperfusion for 2 h. Oral administration of curcumin by gavage at a dose of 200 mg/kg/day lasted 20 days just before inducing the mesenteric ischemia. At the end of reperfusion period, all animals were sacrifi ced and esophagus samples were collected to assess the contractile response to agonists and histopathological alterations. Results: Ischemia/reperfusion signifi cantly decreased the contractile responses to carbachol and KCl and this decrease was attenuated by curcumin. Pretreatment with curcumin caused a remarkable decrease in histopathological parameters such as edema, congestion and infl ammatory cells. Conclusions:The results of the present study demonstrate for the fi rst time that curcumin can attenuate the esophageal injury associated with I/R (Tab. 4, Fig. 3, Ref. 32). Full Text in PDF www.elis.sk.

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“…The increase in blood cytokine levels in AMI indicates that the systemic response appears in the early stages of ischemia, and rather than making the diagnosis, it is valuable in terms of prognosis of the patients. [13,14] In one study, serum IL-6 levels were found to be higher in patients with the diagnosis of AMI compared to the healthy control group. [15] In another study performed by creating SMA occlusion in rats, a significant increase was found in TNF-α, IL-6 and IL-1 levels beginning from the 2nd hour in the ischemia group compared to control and laparotomy groups.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and prognostic value of procalcitonin and phosphorus in acute mesenteric ischemia

Karabulut

Gül²,

Dündar³

et al. 2011

Ulus Travma Acil Cerrahi Derg

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AMAÇAkut mezenter iskemi (AMİ) modeli kullanılarak yapılan bu çalışmada, serum prokalsitonin ve fosfor düzeylerinin AMİ erken tanısında kullanılabilirliği araştırıldı. GEREÇ VE YÖNTEMÇalışmada 21 adet Yeni Zelanda tavşanı kullanıldı. Denekler Kontrol, Sham ve İskemi grubu olarak adlandırıl-dı. Kontrol grubundaki deneklere herhangi bir girişim yapılmadı. Sham ve İskemi grubundaki deneklere orta hat insizyonu ile laparotomi yapıldı. İskemi grubundaki deneklere ise laparatomi yapıldıktan sonra süperior mezenterik arter bulunarak bağlandı. Her üç gruptaki hayvanlardan 0., 1., 3. ve 6. saatlerde kan alındı, bu numunelerden prokalsitonin ve fosfor çalışıldı. BULGULARİskemi grubunda, serum fosfor ve prokalsitonin düzeyle-rindeki yükselme kontrol ve sham gruplarına göre istatistiksel olarak anlamlı bulundu (p<0,05). Fosfor ve prokalsitonin düzeylerinin, iskemi oluşturulduktan sonra 1. saatten itibaren arttığı ve bu yüksekliğin 6 saat boyunca devam ettiği saptandı (p<0,05). SONUÇFosfor ve prokalsitonin'in AMİ'nin erken tanısında ve prognozunda kullanılabilecek önemli parametreler olabileceğini düşünüyoruz.Anahtar Sözcükler: Akut mezenter iskemi; fosfor; prokalsitonin.

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Curcumin Nutrition for the Prevention of Mesenteric Ischemia–Reperfusion Injury: An Experimental Rodent Model

Cited by 27 publications

References 23 publications

Antioxidant and Anti-inflammatory Effects of Curcumin Against Hepatorenal Oxidative Injury in the Experimental Sepsis Model Created in Rats

Antioxidant and Anti-inflammatory Effects of Curcumin Against Hepatorenal Oxidative Injury in the Experimental Sepsis Model Created in Rats

Role of curcumin in mesenteric ischemia – reperfusion injury in rats

Diagnostic and prognostic value of procalcitonin and phosphorus in acute mesenteric ischemia

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