Curcumin, Naringenin and Resveratrol from Natural Plant Products Hold Promising Solutions for Modern World Diseases – A Recent Review

Rathinavel, Thirumalaisamy; Haritha, S.; Jeevarathna, S.; Janani, K.S.Sai; Suresh, K

doi:10.1016/j.sajb.2022.06.027

Cited by 22 publications

(10 citation statements)

References 147 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a plant polyphenol, extensively popularized during the last decades, owing to its promising beneficial effects on human health [ 388 ]. It is a famous non-flavonoid polyphenol, related to the family of stilbenes whose structure consists of two phenolic rings linked by a double bond, which promotes two isomeric conformations: trans- and cis-resveratrol [ 389 , 390 ].…”

Section: The Health Benefits Of Stilbenes (Resveratrol Piceatannol Pt...mentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

View full text Add to dashboard Cite

Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical and medicinal sections to promote human health and prevent and cure different diseases. The most common flavonoids found in nature are anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, and other sub-classes. The impacts of plant flavonoids and other phenolics on human health promoting and diseases curing and preventing are antioxidant effects, antibacterial impacts, cardioprotective effects, anticancer impacts, immune system promoting, anti-inflammatory effects, and skin protective effects from UV radiation. This work aims to provide an overview of phenolic compounds and flavonoids as potential and important sources of pharmaceutical and medical application according to recently published studies, as well as some interesting directions for future research. The keyword searches for flavonoids, phenolics, isoflavones, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, and secoiridoids medicinal plant were performed by using Web of Science, Scopus, Google scholar, and PubMed. Phenolic acids contain a carboxylic acid group in addition to the basic phenolic structure and are mainly divided into hydroxybenzoic and hydroxycinnamic acids. Hydroxybenzoic acids are based on a C6-C1 skeleton and are often found bound to small organic acids, glycosyl moieties, or cell structural components. Common hydroxybenzoic acids include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, and salicylic acids. Hydroxycinnamic acids are based on a C6-C3 skeleton and are also often bound to other molecules such as quinic acid and glucose. The main hydroxycinnamic acids are caffeic, p-coumaric, ferulic, and sinapic acids.

show abstract

Section: The Health Benefits Of Stilbenes (Resveratrol Piceatannol Pt...mentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

View full text Add to dashboard Cite

show abstract

“…The class of stilbenes was represented here by trans-resveratrol, a compound very well researched for its health benefits in several conditions and diseases (Thirumalaisamy et al, 2022;Najafi et al, 2022). Regarding the evolution of trans-resveratrol, it can be noticed that the values oscillated in the range of 4.3-8.0 mg L -1 in 2020 and 5.0-6.5 mg L -1 in 2021, significant increases from a statistical point of view being induced especially by the treatment with chitosan (89% increase in 2020 and 17% in 2021) and less by the climatic variability (Table 3).…”

Section: Influence Of Chitosan Treatments On Winesmentioning

confidence: 99%

Effect of foliar treatment with chitosan on phenolic composition of ῾Fetească neagră’ grapes and wines

Artem¹,

ANTOCE

GEANA³

et al. 2023

Not Bot Horti Agrobo

View full text Add to dashboard Cite

The objective of this study was to determine the influence of chitosan treatments, applied in vineyard for plan protection, on the phenolic quality of grapes. The study was conducted for two consecutive years (2020-2021) in the wine center of Murfatlar, Romania, on ‘Fetească neagră’, an ancient but well-known indigenous Romanian grape variety for red wines. Chitosan is meant to offer an alternative for the classic treatment with Bordeaux mixture (BM), which represented the control variant. A combination treatment with half dose of chitosan and half dose of BM was also applied and evaluated. Chemical composition at harvest time was evaluated by measuring the content of sugar, total acidity, pH, total anthocyanin potential (ApH1), anthocyanins extractable at wine pH (ApH3.2), total polyphenol index, skin tannins, seed tannins and seeds maturity. In wines the colour parameters were determined by spectrophotometry and individual phenolic compounds by UHPLC-HRMS. In grapes, accumulation of anthocyanins increased with the total dose of chitosan applied in the vineyard, with higher values in 2020 when temperatures were higher and the rainfall values were typical for the region. Accumulation of tannins in grape skins followed a similar trend. In wine, chitosan determined a significant 72% increase in colour intensity in 2020. Among the individual phenols gallic acid was predominant, with higher values in the rainier year (2021) and significant increases determined by chitosan treatment (especially in 2021 when it increased by 97% as compared to BM treatment). Catechin and epicatechin recorded important increases in the less favourable year (2021), with confirmed increases in both years elicited by the chitosan. Quercetin and myricetin were not influenced by the chitosan treatment, but their increase was correlated with higher temperatures and inversely correlated to the amount of rainfall. Trans-resveratrol ranged between 4.3-8.0 mg L-1 in 2020 and 5.0-6.5 mg L-1 in 2021, with an important increase determined by the chitosan treatment in 2020 (89% increase compared to BM treatment).

show abstract

“…Recently, scientists have shown greater interest in studying the biological effects of natural compounds, uncovering their potential therapeutic effects on the human body. In contrast to existing chemical therapeutics, plant products and their components offer remedies that have fewer side effects, while exhibiting a synergistic action through combinations of compounds [38]. As a result, numerous natural substances have been researched to help comprehend their superior efficiency in improving many neurological disorders [39].…”

Section: Herbal Drugsmentioning

confidence: 99%

“…In the case of brain injury, curcumin was found to show neuroprotective activities where it increased the viability of cortal neurons which was reduced after the neuron's exposure to oxygen-glucose deprivation/reoxygenation cycle to mimic an ischemic injury in-vitro. Furthermore, curcumin was found to reduce the occurrence of thrombosis limiting cerebral ischemia [38].…”

Section: Curcuminmentioning

confidence: 99%

Lipid nanocarriers encapsulating herbal drugs for brain diseases therapy

Gad

El-Gogary

Geneidi

et al. 2023

Archives of Pharmaceutical Sciences Ain Shams University

View full text Add to dashboard Cite

The blood-brain barrier (BBB) is an essential component in safeguarding the brain and preserving its equilibrium. The BBB represents a challenge for various types of drug delivery systems, particularly in the context of treating numerous neuropathological disorders wherein the therapeutic agents cannot cross the BBB. Nonetheless, existing neurotherapeutics have drawbacks such as toxicity and lack of specificity. Advances in nano drug delivery systems, particularly lipid-based nanocarriers, aim to deliver active therapeutics across the BBB to improve neurological conditions such as Alzheimer's, Parkinson's, and brain tumors, offering a novel treatment strategy with enhanced drug delivery, increased target specificity, enhanced efficacy, and more significantly, minimized toxicity in a biomimetic manner. In this context, this review sheds light on the use of lipid nanocarriers loaded with drugs of natural origin such as ferulic acid, resveratrol, curcumin, and rosmarinic acid for their brain delivery with better bioavailability and exceptional improvement in their therapeutic potential to treat major neurological disorders in future clinics.

show abstract

Curcumin, Naringenin and Resveratrol from Natural Plant Products Hold Promising Solutions for Modern World Diseases – A Recent Review

Cited by 22 publications

References 147 publications

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

Effect of foliar treatment with chitosan on phenolic composition of ῾Fetească neagră’ grapes and wines

Lipid nanocarriers encapsulating herbal drugs for brain diseases therapy

Contact Info

Product

Resources

About