Curcumin nanoparticles loaded hydrogels protects against aflatoxin B1-induced genotoxicity in rat liver

Abdel-Wahhab, Mosaad A.; Salman, Asmaa S.; Ibrahim, Mohamed Izham Mohamed; El-Kady, Ahmed A.; Abdel-Aziem, Sekena H.; Hassan, Nabila S.; Waly, A.

doi:10.1016/j.fct.2016.06.005

Cited by 44 publications

(17 citation statements)

References 86 publications

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“…It is possible that the circulating toxicant could damage visceral organs and their functions and consequently change the levels of their main metabolites (Kumar & Balachandran, ). Similarly, increased liver dysfunction was observed in the AFB 1 diet in this study, based on the liver function biomarkers, including cholesterol, GPT, GOT and ALK, which was consistent with reports that AFB 1 could damage visceral functions (Abdel‐Wahhab et al., ; El‐Nekeety et al., ) and alter transaminase activity (Kumar & Balachandran, ; Sandhya & Vardhani, ).…”

Section: Discussionsupporting

confidence: 92%

Effects of lactic acid bacteria and smectite after aflatoxin B₁ challenge on the growth performance, nutrient digestibility and blood parameters of broilers

Liu

Ding

Wang

et al. 2018

Animal Physiology Nutrition

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This study aimed to investigate the effect of lactic acid bacteria (LAB) and smectite on the growth performance, nutrient digestibility and blood parameters of broilers that were fed diets contaminated with aflatoxin B (AFB ). A total of 480 newly hatched male Arbor Acres broilers were randomly allocated into four groups with six replicates of 20 chicks each. The broilers were fed diets with the AFB (40 μg/kg) challenge or without (control) it and supplemented with smectite (3.0 g/kg) or LAB (4.0 × 10 CFU/kg) based on the AFB diet. The trial lasted for 42 days. The results showed that during days 1-42 of AFB challenge, the feed intake (FI) and body weight gain (BWG) were depressed (p < .05). The inclusion of LAB and smectite increased (p < .05) the BWG by 71.58 and 41.89 g/bird, respectively, which reached the level of the control diet (p ≥ .05), but there were no differences (p ≥ .05) in performance between LAB and smectite. LAB and smectite also increased (p < .05) the apparent total tract digestibility of the crude protein. Regarding the blood parameters, AFB decreased (p < .05) the levels of red blood cell count, haematocrit, mean corpuscular volume, haemoglobin, albumin and total protein. In the meantime, the AFB increased (p < .05) leucocyte counts, urea nitrogen, cholesterol, total bilirubin, creatinine, glutamic-pyruvic transaminase, glutamic oxaloacetic transaminase and alkaline phosphatase. By contrast, LAB and smectite affected (p < .05) these parameters in the opposite direction. It can be concluded that after the AFB challenge, LAB and smectite have similar effects on the growth and health of the broilers, suggesting that LAB could be an alternative against AFB in commercial animal feeds.

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Section: Discussionsupporting

confidence: 92%

Effects of lactic acid bacteria and smectite after aflatoxin B₁ challenge on the growth performance, nutrient digestibility and blood parameters of broilers

Liu

Ding

Wang

et al. 2018

Animal Physiology Nutrition

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“…( Abdel-Wahhab, 2015 ), regulates pharmacological activities in a direct or indirect way and modulates various signaling molecules including cell survival proteins, apoptosis, drug resistance protein, etc. ( Basak et al, 2015 ; Abdel-Wahhab et al, 2016 ), and possess the ability to scavenge free radicals ( Trujillo et al, 2013 ). Our data also showed that curcumin prevented liver dysfunction due to its anti-oxidant activity as well as modulating drug metabolizing enzymes including liver phase-I enzymes, Nrf2, and phase-II enzymes.…”

Section: Discussionmentioning

confidence: 99%

Dual Role of Dietary Curcumin Through Attenuating AFB1-Induced Oxidative Stress and Liver Injury via Modulating Liver Phase-I and Phase-II Enzymes Involved in AFB1 Bioactivation and Detoxification

et al. 2018

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It is well understood that liver cytochrome p450 enzymes are responsible for AFB1 bioactivation, while phase-II enzymes regulated by the transcription factor nuclear factor-erythroid-2-related factor 2 (Nrf2) are involved in detoxification of AFB1. In this study, we explored the potential of curcumin to prevent AFB1-induced liver injury by modulating liver phase-I and phase-II enzymes along with Nrf2 involved in AFB1 bioactivation and detoxification. Arbor Acres broiler were divided into four groups including control group (G1; fed only basal feed), curcumin alone-treated group (G2; 450 mg/kg feed), AFB1-fed group (G3; 5 mg/kg feed), and curcumin plus AFB1 group (G4; 5 mg AFB1+450 mg curcumin/kg feed). After 28 days, liver and blood samples were collected for different analyses. Histological and phenotypic results revealed that AFB1-induced liver injury was partially ameliorated by curcumin supplementation. Compared to AFB1 alone-treated group, serum biochemical parameters and liver antioxidant status showed that curcumin supplementation significantly prevented AFB1-induced liver injury. RT-PCR and western blot results revealed that curcumin inhibited CYP enzymes-mediated bioactivation of AFB1 at mRNA and protein level. Transcription factor Nrf2, its downstream genes such as GSTA3, and GSTM2 mRNA, and protein expression level significantly upregulated via dietary curcumin. In addition, GSTs enzyme activity was enhanced with dietary curcumin which plays a crucial role in AFB1-detoxification. Conclusively, the study provided a scientific basis for the use of curcumin in broiler’s diet and contributed to explore the multi-target preventive actions of curcumin against AFB1-induced liver injury through the modulation of phase-I and phase-II enzymes, and its potent anti-oxidative effects.

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“…Curcumin can improve significantly the antioxidant status of the liver and restrict oxidative damage caused by AFB1 (Limaye, Yu, Chou, Liu, & Cheng, ). Interestingly, curcumin nanoparticles loaded hydrogels were also found to offer protection against AFB1‐induced genotoxicity in rat liver (Abdel‐Wahhab et al., ). The polyphenolic fraction of virgin olive oil was found to provide protection against the pro‐oxidative and cytotoxic effects of AOH (Chiesi, Fernandez‐Blanco, Cossignani, Font, & Ruiz, ).…”

Section: Food Compounds Especially Those Of Plant Origin For Prevenmentioning

confidence: 99%

The Significance of Regulatory MicroRNAs: Their Roles in Toxicodynamics of Mycotoxins and in the Protection Offered by Dietary Therapeutics Against Mycotoxin‐Induced Toxicity

Xue

Sun‐Waterhouse

Wang

et al. 2018

Comp Rev Food Sci Food Safe

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Mycotoxins are contaminants commonly found in foods and represent a worldwide threat to human health and welfare. Efforts have been undertaken to reduce mycotoxins and their toxicity, including the introduction of good agricultural practices, appropriate food processing, specific biotransformation approaches, and pursue therapeutic agents to counteract mycotoxins. Efficient and predictive tools are required for investigations on mycotoxins and their toxicodynamics, and strategies for mycotoxin reduction. Gene expression and transcriptome analysis can unravel the mode of action, transformation and combined toxicity of mycotoxins, or mycotoxin's interactions with food components including dietary therapeutics, at the cellular level and from a molecular perspective. MicroRNAs (miRNAs) regulate endogenously and posttranscriptionally the expression of target genes and enzymes involved in physiological, disease and toxicological responses, and the metabolism of therapeutic agents. Accordingly, this review aimed to collect up‐to‐date information on (1) the regulatory role of miRNAs in mycotoxin‐initiated toxicological processes and (2) the protective role of active ingredients from plants on mycotoxin‐induced toxicity. Through such a review of published evidence, we found some common signal pathways involving miRNAs shared by these two types of biological events. This finding indicates the possibility of using miRNAs as biomarkers in assessing and controlling mycotoxins in food via cellular mechanisms.

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Curcumin nanoparticles loaded hydrogels protects against aflatoxin B1-induced genotoxicity in rat liver

Cited by 44 publications

References 86 publications

Effects of lactic acid bacteria and smectite after aflatoxin B₁ challenge on the growth performance, nutrient digestibility and blood parameters of broilers

Effects of lactic acid bacteria and smectite after aflatoxin B₁ challenge on the growth performance, nutrient digestibility and blood parameters of broilers

Dual Role of Dietary Curcumin Through Attenuating AFB1-Induced Oxidative Stress and Liver Injury via Modulating Liver Phase-I and Phase-II Enzymes Involved in AFB1 Bioactivation and Detoxification

The Significance of Regulatory MicroRNAs: Their Roles in Toxicodynamics of Mycotoxins and in the Protection Offered by Dietary Therapeutics Against Mycotoxin‐Induced Toxicity

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Curcumin nanoparticles loaded hydrogels protects against aflatoxin B1-induced genotoxicity in rat liver

Cited by 44 publications

References 86 publications

Effects of lactic acid bacteria and smectite after aflatoxin B1 challenge on the growth performance, nutrient digestibility and blood parameters of broilers

Effects of lactic acid bacteria and smectite after aflatoxin B1 challenge on the growth performance, nutrient digestibility and blood parameters of broilers

Dual Role of Dietary Curcumin Through Attenuating AFB1-Induced Oxidative Stress and Liver Injury via Modulating Liver Phase-I and Phase-II Enzymes Involved in AFB1 Bioactivation and Detoxification

The Significance of Regulatory MicroRNAs: Their Roles in Toxicodynamics of Mycotoxins and in the Protection Offered by Dietary Therapeutics Against Mycotoxin‐Induced Toxicity

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Product

Resources

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Effects of lactic acid bacteria and smectite after aflatoxin B₁ challenge on the growth performance, nutrient digestibility and blood parameters of broilers

Effects of lactic acid bacteria and smectite after aflatoxin B₁ challenge on the growth performance, nutrient digestibility and blood parameters of broilers