Curcumin nanoformulations to combat aging-related diseases

Mahjoob, Maryam; Stochaj, Ursula

doi:10.1016/j.arr.2021.101364

Cited by 49 publications

(23 citation statements)

References 274 publications

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“…Additional investigations are needed to determine the most appropriate dose fractionation schedule for lethal autophagy and local innervated niche damage with minimal toxicity. Enhanced bioavailability and tissue targeting of natural compounds by nanoengineering promises to bring natural products similar to curcumin to the forefront of drugs repurposing for cancer therapy in the near future ( Mahjoob and Stochaj, 2021 ; Xu et al, 2021 ).…”

Section: Drug Repurposing For Cancer Therapy: Targeting Autophagy In ...mentioning

confidence: 99%

Drug repurposing in cancer neuroscience: From the viewpoint of the autophagy-mediated innervated niche

Shi

et al. 2022

Front. Pharmacol.

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Based on the bidirectional interactions between neurology and cancer science, the burgeoning field “cancer neuroscience” has been proposed. An important node in the communications between nerves and cancer is the innervated niche, which has physical contact with the cancer parenchyma or nerve located in the proximity of the tumor. In the innervated niche, autophagy has recently been reported to be a double-edged sword that plays a significant role in maintaining homeostasis. Therefore, regulating the innervated niche by targeting the autophagy pathway may represent a novel therapeutic strategy for cancer treatment. Drug repurposing has received considerable attention for its advantages in cost-effectiveness and safety. The utilization of existing drugs that potentially regulate the innervated niche via the autophagy pathway is therefore a promising pharmacological approach for clinical practice and treatment selection in cancer neuroscience. Herein, we present the cancer neuroscience landscape with an emphasis on the crosstalk between the innervated niche and autophagy, while also summarizing the underlying mechanisms of candidate drugs in modulating the autophagy pathway. This review provides a strong rationale for drug repurposing in cancer treatment from the viewpoint of the autophagy-mediated innervated niche.

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Section: Drug Repurposing For Cancer Therapy: Targeting Autophagy In ...mentioning

confidence: 99%

Drug repurposing in cancer neuroscience: From the viewpoint of the autophagy-mediated innervated niche

Shi

et al. 2022

Front. Pharmacol.

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“…( Zhou et al, 2011 ; Mandal et al, 2020 ; Fu et al, 2021 ). Numerous studies have revealed the beneficial role of curcumin in cancer, diabetes, metabolic diseases, autoimmune diseases, atherosclerosis, arthritis, pulmonary diseases, etc ( Aggarwal and Harikumar, 2009 ; Jabczyk et al, 2021 ; Mahjoob and Stochaj, 2021 ). Recently, researchers discovered that curcumin also has neuroprotective effects on various neurological diseases, including neuropsychiatric disorders, neurodegenerative diseases, traumatic brain injury, spinal cord injury, and epilepsy ( Dhir, 2018 ; Bhat et al, 2019 ; Yavarpour-Bali et al, 2019 ; Yuan et al, 2019 ; Farkhondeh et al, 2020 ; Nebrisi, 2021 ; Lamanna-Rama et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Mechanisms Underlying Curcumin-Induced Neuroprotection in Cerebral Ischemia

Feng

Meng²

2022

Front. Pharmacol.

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Ischemic stroke is the leading cause of death and disability worldwide, and restoring the blood flow to ischemic brain tissues is currently the main therapeutic strategy. However, reperfusion after brain ischemia leads to excessive reactive oxygen species production, inflammatory cell recruitment, the release of inflammatory mediators, cell death, mitochondrial dysfunction, endoplasmic reticulum stress, and blood–brain barrier damage; these pathological mechanisms will further aggravate brain tissue injury, ultimately affecting the recovery of neurological functions. It has attracted the attention of researchers to develop drugs with multitarget intervention effects for individuals with cerebral ischemia. A large number of studies have established that curcumin plays a significant neuroprotective role in cerebral ischemia via various mechanisms, including antioxidation, anti-inflammation, anti-apoptosis, protection of the blood–brain barrier, and restoration of mitochondrial function and structure, restoring cerebral circulation, reducing infarct volume, improving brain edema, promoting blood–brain barrier repair, and improving the neurological functions. Therefore, summarizing the results from the latest literature and identifying the potential mechanisms of action of curcumin in cerebral ischemia will serve as a basis and guidance for the clinical applications of curcumin in the future.

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“…Curcumin (CUR) is the main active ingredient extracted from turmeric, a plant known for its medicinal properties and various pharmacological activities ( Kocaadam and Şanlier, 2017 ; Chopra et al, 2021 ). Various pharmacological studies have shown that CUR has anti-inflammatory, antioxidant, anti-tumor, and anti-vascular remodeling effects ( Aggarwal and Harikumar, 2009 ; Walker and Mittal, 2020 ; Mahjoob and Stochaj, 2021 ). Existing evidence suggests that CUR has therapeutic potential for a variety of human diseases ( Oskouie et al, 2019 ; Kao et al, 2020 ; Mirzaei et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of curcumin in psoriasis: preclinical and clinical evidence and possible mechanisms

et al. 2022

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Background: Psoriasis is a chronic and immune-mediated inflammatory skin disease. Many studies have shown that curcumin (CUR) has strong anti-inflammatory effects and can improve psoriasis; however, its efficacy and safety have not been confirmed, and the specific mechanism remains to be elucidated.Objective: To evaluate the efficacy, safety, and possible mechanisms of CUR in the treatment of psoriasis.Methods: The Cochrane Library, Embase, PubMed, Web of Science, China National Knowledge Infrastructure, Wanfang, and VIP (China Science and Technology Journal Database) were systematically searched for clinical trials and preclinical studies on the use of CUR in psoriasis treatment. All databases were searched from inception to January 2022. The meta-analysis was performed using RevMan 5.3 software.Results: Our meta-analysis included 26 studies, comprising seven clinical randomized controlled trials and 19 preclinical studies. A meta-analysis of clinical trials showed that both CUR monotherapy and combination therapy improved Psoriasis Area and Severity Index (PASI) scores in patients compared to controls (standard mean difference [std.MD]: −0.83%; 95% confidence interval [CI]: −1.53 to 0.14; p = 0.02). In preclinical studies, CUR showed better performance in improving the phenotype of psoriatic dermatitis mice compared to controls, including total PASI score (std.MD: 6.50%; 95% CI: 10.10 to −2.90; p = 0.0004); ear thickness (p = 0.01); and the expression of inflammatory cytokines such as interleukin (IL)-17, tumor necrosis factor (TNF)-α, IL-17F, and IL-22 (p < 0.05). In cell studies, CUR inhibited cell proliferation (p = 0.04) and the cell cycle (p = 0.03) and downregulated the inflammatory cytokines IL-6 and IL-8 (p < 0.05).Conclusions: CUR has excellent efficacy and broad potential to treat psoriasis in multiple ways. Its use also plays a crucial role in improving the psoriasis phenotype and reducing the inflammatory microenvironment. In conclusion, our findings suggest that CUR alone or in combination with other conventional treatments can effectively treat psoriasis.

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Curcumin nanoformulations to combat aging-related diseases

Cited by 49 publications

References 274 publications

Drug repurposing in cancer neuroscience: From the viewpoint of the autophagy-mediated innervated niche

Drug repurposing in cancer neuroscience: From the viewpoint of the autophagy-mediated innervated niche

Mechanisms Underlying Curcumin-Induced Neuroprotection in Cerebral Ischemia

Efficacy and safety of curcumin in psoriasis: preclinical and clinical evidence and possible mechanisms

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