Curcumin: Modern Applications for a Versatile Additive

Abstract

The recent development of several methods for extracting curcumin from the root of the plant Curcuma longa has led to intensified research on the properties of curcumin and its fields of application. Following the studies and the accreditation of curcumin as a natural compound with antifungal, antiviral, and antibacterial properties, new fields of application have been developed in two main directions—food and medical, respectively. This review paper aims to synthesize the fields of application of curcumin as an additive for the prevention of spoilage, safety, and quality of food. Simultaneously, it aims to present curcumin as an additive in products for the prevention of bacterial infections and health care. In both cases, the types of curcumin formulations in the form of (nano)emulsions, (nano)particles, or (nano)composites are presented, depending on the field and conditions of exploitation or their properties to be used. The diversity of composite materials that can be designed, depending on the purpose of use, leaves open the field of research on the conditioning of curcumin. Various biomaterials active from the antibacterial and antibiofilm point of view can be intuited in which curcumin acts as an additive that potentiates the activities of other compounds or has a synergistic activity with them.

Biomaterials for the Prevention of Oral Candidiasis Development

“…Its antifungal activity is exhibited through various mechanisms, such as targeting metabolic paths, inducing apoptosis, and increasing reactive oxygen species. These properties of curcumin are effective in the design of drug formulations with fewer side effects and superior performance [53,[121][122][123][124]. Narayanan et al [125] have evaluated curcumin's inhibitory action against C. albicans, C. parapsilosis, C. glabrata, and C. dublieniensis, proving its potential as a therapeutic alternative to conventional antifungals.…”

Curcumin and Its New Derivatives: Correlation between Cytotoxicity against Breast Cancer Cell Lines, Degradation of PTP1B Phosphatase and ROS Generation

“…Compound 8 was prepared according to Typical procedure 1 from (E)-3-benzylidene-1-methylpiperidin-4-one (1.610 g, 8.0 mmol) [51] and (E)-4-(3-cyano-3-oxoprop-1-en-1-yl)-2-methoxyphenyl methyl carbonate (1.841 g, 7.0 mmol) [25] and purified by flash column chromatography (AcOEt:Toluene 44, 151.33, 141.42, 141.37, 135.37, 134.20, 133.40, 130.47, 129.97 (3E,5E)-3,5-Bis(4-hydroksy-3-metoksyfenylo)-1-metylopiperyd-4-on (9) To N-metylopiperyd-4-one (1.357 g, 12.02 mmol), vanillin (4.226 g, 27.78 mmol) and acetic acid (99%, 4 mL) were added. The reaction was heated to 45 • C for two days then the temperature was increased to 100 • C and heated for an additional day.…”

“…One of the prospective substances, due to a wide range of activity in vivo tests and low toxicity, is curcumin [(1,7-bis(4-hydroxy-3methoxyphenyl)-1,6-heptadiene-3,5-dione)] (Figure 1) [1,2]. many of them are derived from biomolecules of natural substances, due to a wide range of activity in vivo tests an bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dion This phenolic compound is a constituent of the natu Curcuma longa and is widely used in traditional eastern can be safely consumed in huge doses-up to 12 g in a s tests conducted, shows antioxidant [4], anti-inflammation [7], and many other biological activities [8,9]. Although properties, it has poor bioavailability and a weak pharmac this are poor solubility in aqueous gastrointestinal fluids intestinal tract, and instability at physiological pH-at a p cumin is only 1 to 9 min.…”

“…As a food additive, it can be safely consumed in huge doses-up to 12 g in a single dose [3]. Curcumin, in the tests conducted, shows antioxidant [4], anti-inflammation [5], anti-fungal [6], anti-cancer [7], and many other biological activities [8,9]. Although curcumin has many promising properties, it has poor bioavailability and a weak pharmacokinetic profile.…”

Modeling the Properties of Curcumin Derivatives in Relation to the Architecture of the Siloxane Host Matrices

“…The physical and chemical properties of these structures are influenced by the type of dye conditioning, such as micelles [ 8 , 27 ], nanoparticles [ 6 ], or composite materials [ 28 , 29 , 30 ]. The targeted field of application is very important in choosing the type of conditioning of curcumin derivatives [ 31 ]. From this point of view, curcumin is used as a food additive in the form of micelles or nanoparticles [ 32 , 33 , 34 ].…”