Curcumin, mitochondrial biogenesis, and mitophagy: Exploring recent data and indicating future needs

Oliveira, Marcos Roberto de; Jardim, Fernanda Rafaela; Setzer, William N.; Nabavi, Seyed Mohammad; Nabavi, Seyed Fazel

doi:10.1016/j.biotechadv.2016.04.004

Cited by 81 publications

(48 citation statements)

References 220 publications

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“…Inhibitors of histone acetyltransferases have also shown to revert mitochondrial oxidative stress. The dietary compound curcumin, an inhibitor of the histone acetyltransferase CBP/p300, has shown to rescue hyperglycemia-induced endothelial dysfunction by regulating the expression of several pro-oxidant and antioxidant enzymes involved in mitochondrial oxidative stress and mitochondrial biogenesis (194). Similarly, inhibition of another acetyltransferase, GCN5, prevents angiotensin II-mediated downregulation of catalase thus fostering accumulation of mitochondrial ROS (195).…”

Section: Epigenetic Therapiesmentioning

confidence: 99%

Epigenetic Control of Mitochondrial Function in the Vasculature

Mohammed

Ambrosini

Lüscher

et al. 2020

Front. Cardiovasc. Med.

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The molecular signatures of epigenetic regulation and chromatin architecture are emerging as pivotal regulators of mitochondrial function. Recent studies unveiled a complex intersection among environmental factors, epigenetic signals, and mitochondrial metabolism, ultimately leading to alterations of vascular phenotype and increased cardiovascular risk. Changing environmental conditions over the lifetime induce covalent and post-translational chemical modification of the chromatin template which sensitize the genome to establish new transcriptional programs and, hence, diverse functional states. On the other hand, metabolic alterations occurring in mitochondria affect the availability of substrates for chromatin-modifying enzymes, thus leading to maladaptive epigenetic signatures altering chromatin accessibility and gene transcription. Indeed, several components of the epigenetic machinery require intermediates of cellular metabolism (ATP, AcCoA, NADH, α-ketoglutarate) for enzymatic function. In the present review, we describe the emerging role of epigenetic modifications as fine tuners of gene transcription in mitochondrial dysfunction and vascular disease. Specifically, the following aspects are described in detail: (i) mitochondria and vascular function, (ii) mitochondrial ROS, (iii) epigenetic regulation of mitochondrial function; (iv) the role of mitochondrial metabolites as key effectors for chromatin-modifying enzymes; (v) epigenetic therapies. Understanding epigenetic routes may pave the way for new approaches to develop personalized therapies to prevent mitochondrial insufficiency and its complications.

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Section: Epigenetic Therapiesmentioning

confidence: 99%

Epigenetic Control of Mitochondrial Function in the Vasculature

Mohammed

Ambrosini

Lüscher

et al. 2020

Front. Cardiovasc. Med.

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“…Curcumin do not localize at the mitochondria. Previous publications show that curcumin is involved in mitochondrial destabilization (8,25) and induces mitochondrial biogenesis (26). Hypothetically, if curcumin treatment increases the ratio of Bax/Bcl-2 or results in a leaky mitochondrial membrane, curcumin could be linked to mitochondrial destabilization, apoptosis, and mitophagy (8,18,27).…”

Section: Discussionmentioning

confidence: 98%

Highlighting curcumin-induced crosstalk between autophagy and apoptosis: A biochemical approach coupling impedancemetry, imaging, and flow cytometry

Oyanguren

Rainey

Moustapha

et al. 2019

Preprint

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These authors contributed equally.Curcumin, a major active component of turmeric (Curcuma longa, L.), is known to have various effects on both healthy and cancerous tissues. In vitro studies suggest that curcumin inhibits cancer cell growth by activating apoptosis, but the mechanism underlying the anticancer effects of curcumin is still unclear. Since there is a consensus about endoplasmic reticulum (ER) stress being involved in the cytotoxicity of many natural compounds, we investigated by Amnis ® Imaging flow cytometry the mechanistic aspects of curcumin's destabilization of the ER, but also the status of the lysosomal compartment involved in curcumin-associated apoptosis. Curcumin induces ER stress thereby causing an unfolded protein response (UPR) and calcium release which destabilize the mitochondrial compartment and induce apoptosis. These events are also associated with secondary lysosomal membrane permeabilization and activation of caspase-8, mediated by activation of cathepsins and calpains. We previously showed that sequence lead to the generation of truncated tBid and disruption of mitochondrial homeostasis. These two pathways of different intensities and momentum converge towards an amplification of cell death that still needs to be studied in more detail. It has been suggested that it may be possible to exploit autophagy for cancer therapy. There is a complex interplay involving early autophagy as soon as mitochondria produce superoxide anions and hydrogen peroxide. Treatments with 10 µM to 20 µM curcumin induce autophagosome formation, while only early events of cell death are detectable.In the present study, curcumin-induced autophagy failed to rescue all cells since most cells underwent type II cell death following initial autophagic processes. However, a small number of cells blocked in the cell cycle escaped and were rescued to give rise to a novel proliferation phase. Curcumin | cell death | autophagy | apoptosis | ROS | Calcium | Stress | Mitochondria | Endoplasmic reticulum | cancer |

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“…It has also been observed that curcumin can modulate the activity of various important transcription factors, growth factors, inflammatory cytokines, protein kinase, and other enzymes (Milani, Basirnejad, Shahbazi, & Bolhassani, ; Perrone et al, ; Stanic, ). These activities of curcumin can lead to several biological effects, including the inhibition of free radicals production, oxidative stress reduction, and inhibition of the transcription of genes implicated in oxidative stress and inflammatory responses (Darvesh, Aggarwal, & Bishayee, ; de Oliveira, Jardim, Setzer, Nabavi, & Nabavi, ; Nabavi et al, ; Perrone et al, ; Stanic, ).…”

Section: Introductionmentioning

confidence: 99%

“…Extensive clinical trials over the past quarter century have addressed the pharmacokinetics, the exceptional pharmacological safety, and efficacy of this nutraceutical against numerous human diseases (Darvesh et al, ; de Oliveira et al, ; Gota et al, ; Gupta et al, ; WHO, ). Some promising effects have been observed in patients with obesity, metabolic syndrome, and diabetes, as well as different types of cancer, depression, arthritis, skin diseases, inflammatory bowel disease, muscle lesions, premenstrual syndrome symptoms, gynecological diseases, and inflammation (Nabavi et al, ; Perrone et al, ).…”

Section: Introductionmentioning

confidence: 99%

Effects of curcumin consumption on human chronic diseases: A narrative review of the most recent clinical data

Mantzorou

Pavlidou

Vasios

et al. 2018

Phytotherapy Research

102

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Numerous clinical trials have investigated the potential beneficial effects of curcumin supplementation against several human chronic diseases. Up to now, it has been claimed that curcumin consumption may exert beneficial effects against several chronic diseases by promoting human health and preventing diseases. In this aspect, the present review aims to critically collect and in-depth summarize the most recent, well-designed clinical studies evaluating the potential beneficial effects of curcumin consumption on human health promotion and disease prevention. According to recent and well-designed clinical studies, curcumin consumption may benefit against obesity, metabolic syndrome, and diabetes. Moreover, curcumin consumption seems to exert a positive effect on people suffering from various types of cancer, fatty liver disease, depression, arthritis, skin diseases, gut inflammation, and symptoms of premenstrual syndrome. Due to the strong heterogeneity among the clinical studies concerning the exact effective curcumin dose and formulation, as well as the recommended treatment duration for each chronic disease, no precise and definitive conclusions could be drawn. Further large-scale prospective studies are strongly recommended, being well-designed as far as follow-up times, dosage, formulation, and duration of curcumin supplementation are concerned. Moreover, potential confounders in each specific chronic disease should carefully be taken into account in future studies.

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Curcumin, mitochondrial biogenesis, and mitophagy: Exploring recent data and indicating future needs

Cited by 81 publications

References 220 publications

Epigenetic Control of Mitochondrial Function in the Vasculature

Epigenetic Control of Mitochondrial Function in the Vasculature

Highlighting curcumin-induced crosstalk between autophagy and apoptosis: A biochemical approach coupling impedancemetry, imaging, and flow cytometry

Effects of curcumin consumption on human chronic diseases: A narrative review of the most recent clinical data

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