Curcumin mitigates cerebral vasospasm and early brain injury following subarachnoid hemorrhage via inhibiting cerebral inflammation

Abstract

Background and PurposeSubarachnoid hemorrhage (SAH)‐induced cerebral vasospasm and early brain injury is a fatal clinical syndrome. Cerebral vasospasm and early brain injury are associated with inflammatory response and oxidative stress. Whether curcumin, which plays important roles to regulate inflammatory cytokines and inhibit oxidative stress, inhibits SAH‐induced inflammation and oxidative stress are largely unknown.MethodsAdult male rats underwent autologous blood injection into prechiasmatic cistern to induce SAH. Curcumin (150 mg/kg) was administered at 0.5, 24 and 48 hr post‐SAH. Mortality calculation and neurological outcomes as well as morphological vasospasm of anterior cerebral artery were studied. Superoxide dismutase, lipid peroxidation, and inflammatory cytokines (MCP‐1 and TNF‐α) expression in prefrontal region were quantified. Furthermore, p65 and phosphor‐p65 were quantitatively analyzed.ResultsCurcumin remarkedly reduced mortality and ameliorated neurological deficits after SAH induction (p < .05); morphological results showed that cerebral vasospasm in curcumin‐treated group was mitigated (p < .05). SAH‐induced MCP‐1 and TNF‐α overexpression were inhibited in curcumin‐treated group (p < .05). Importantly, phosphor‐p65 was significantly inhibited after curcumin treatment (p < .05).ConclusionsCurcumin can inhibit SAH‐induced inflammatory response via restricting NF‐κB activation to alleviate cerebral vasospasm and early brain injury.

Persistent Malfunction of Glymphatic and Meningeal Lymphatic Drainage in a Mouse Model of Subarachnoid Hemorrhage

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Increased concentration of serum periostin is associated with poor outcome of patients with aneurysmal subarachnoid hemorrhage

“…What's more, more than 1/3 of aSAH patients suffered cognitive impairment and experienced a decline of quality of life . Cerebral vasospasm (CVS) and early brain injury (EBI) are regarded as the main causes of poor outcome of patients with aSAH . Accumulated evidences have showed that inflammatory response, oxidative stress and peripheral immune response are significantly associated with CVS and EBI .…”

Hepato therapeutic Efficacy of Native Curcumim and Nano –curcumin : A Novel Therapy Against Hyperthyroidism Induced Liver Oxidative and Inflammatory Damage in Rats

“…Curcumin longa, commonly referred as turmeric, is used widespread as an essential spice in food preparations mainly due to its medicinal properties. Curcumin exhibits a number of medicinal properties including anti-diabetic [1], anti-arthritic [2], anti-oxidant [3], anti-inflammatory [4], antimicrobial [5], anti-neurodegenerative [6]and anticancer [7]. Despite the widespread applications, the beneficial effects of curcumin are hampered by its poor bioavailability which results from its high metabolic and excretion rates, poor absorption and minimal water insolubility [8].…”