Curcumin Metabolite Tetrahydrocurcumin in the Treatment of Eye Diseases

Kao, Yu-Wen; Hsu, Sheng‐Kai; Chen, Jeff Yi‐Fu; Lin, I‐Ling; Chen, Kuo-Jen; Lee, Po-Yen; Ng, Hui-Suan; Chiu, Chien‐Chih; Cheng, Kai‐Chun

doi:10.3390/ijms22010212

Cited by 30 publications

(14 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there is a lack of consensus among ophthalmologists and researchers on the interest of nutritional supplements containing antioxidant vitamins, carotenoids, trace elements and/or ω3 PUFAs in ophthalmology. Dry eye disease [14][15][16], myopia complications and progression [72], cataracts [32,73], or sightthreatening diseases such as glaucoma, DR, and AMD [16][17][18][19][20][21]32,[74][75][76][77][78][79], have been important targets of antioxidants and ω3 PUFAs. DHA is an essential structural constituent of cell membranes.…”

Section: Discussionmentioning

confidence: 99%

Signature of Circulating Biomarkers in Recurrent Non-Infectious Anterior Uveitis. Immunomodulatory Effects of DHA-Triglyceride. A Pilot Study

et al. 2021

View full text Add to dashboard Cite

The purpose of this study was to identify circulating biomarkers of recurrent non-infectious anterior uveitis (NIAU), and to address the anti-inflammatory effects of triglyceride containing docosahexaenoic acid (DHA-TG). A prospective multicenter study was conducted in 72 participants distributed into: patients diagnosed with recurrent NIAU in the quiescence stage (uveitis group (UG); n = 36) and healthy controls (control group (CG); n = 36). Each group was randomly assigned to the oral supplementation of one pill/day (+) containing DHA-TG (n = 18) or no-pill condition (−) (n = 17) for three consecutive months. Data from demographics, risk factors, comorbidities, eye complications and therapy were recorded. Blood was collected and processed to determine pro-inflammatory biomarkers by bead-base multiplex assay. Statistical processing with multivariate statistical analysis was performed. The mean age was 50, 12 (10, 31) years. The distribution by gender was 45% males and 55% females. The mean number of uveitis episodes was 5 (2). Higher plasma expression of interleukin (IL)-6 was detected in the UG versus the CG (p = 5 × 10−5). Likewise, significantly higher plasma levels were seen for IL-1β, IL-2, INFγ (p = 10−4), and TNFα (p = 2 × 10−4) in the UG versus the CG. Significantly lower values of the above molecules were found in the +DHA-TG than in the -DHA-TG subgroups, after 3 months of follow-up, TNFα (p = 10−7) and IL-6 (p = 3 × 10−6) being those that most significantly changed. Signatures of circulating inflammatory mediators were obtained in the quiescent stage of recurrent NIAU patients. This 3-month follow-up strongly reinforces that a regular oral administration of DHA-TG reduces the inflammatory load and may potentially supply a prophylaxis-adjunctive mediator for patients at risk of uveitis vision loss.

show abstract

Section: Discussionmentioning

confidence: 99%

Signature of Circulating Biomarkers in Recurrent Non-Infectious Anterior Uveitis. Immunomodulatory Effects of DHA-Triglyceride. A Pilot Study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In other studies involving Ahr −/− mice, while Ahr −/− mice developed severe cardiac fibrosis after Ang II infusion compared with wild-type mice 88 , these mice were also found to be hypotensive in response to Ang II, and Ahr +/− mice were normotensive in response 89 . Furthermore, another study showed that treatment with tryptophan supplementation during pregnancy protects adult rat offspring from hypertension programmed by maternal chronic kidney disease 90 , suggesting possible dietary intervention therapies against pathologies related to the interplay between AHR and renin-angiotensin signaling. Taken together with our findings, the current research suggests that endogenous AHR signaling may play a role in developing ‘heart failure’ states, and that mitigation of this signaling such as via TCDD in adults may give rise to a ‘compensated’ state of mild hypertrophy in response to Ang II in comparison to a ‘heart failure’ state in corn oil controls.…”

Section: Discussionmentioning

confidence: 99%

Developmental and lifelong dioxin exposure induces measurable changes in cardiac structure and function in adulthood

Gannes

Koch

Puga

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Congenital heart disease (CHD) is the most common congenital abnormality. A precise etiology for CHD remains elusive, but likely results from interactions between genetic and environmental factors during development, when the heart adapts to physiological and pathophysiological conditions. Further, it has become clearer that early exposure to toxins that do not result in overt CHD may be associated with adverse cardiac outcomes that are not manifested until later life. Previously, interference with endogenous developmental functions of the aryl hydrocarbon receptor (AHR), either by gene ablation or by in utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a potent AHR ligand, was shown to cause structural, molecular and functional cardiac abnormalities and altered heart physiology in mouse embryos. Here, we show that continuous exposure to TCDD from fertilization throughout adulthood caused male mice to underperform at exercise tolerance tests compared to their control and female counterparts, confirming previous observations of a sexually dimorphic phenotype. Renin-angiotensin stimulation by angiotensin II (Ang II) caused measurable increases in blood pressure and left ventricle mass, along with decreased end diastolic volume and preserved ejection fraction. Interestingly, TCDD exposure caused measurable reductions in the myocardial hypertrophic effects of Ang II, suggesting that endogenous AHR signaling present in adulthood may play a role in the pathogenesis of hypertrophy. Overall, the findings reported in this pilot study highlight the complex systems underlying TCDD exposure in the development of cardiac dysfunction in later life.

show abstract

“…Curcumin has poor solubility and is difficult to add to eye drops. The bioavailability of curcumin has been improved through the development of the curcumin derivative tetrahydrocurcumin (THC) [248]. The solubility, stability, and release rate of curcumin can also be controlled through the use and development of nanocarriers.…”

Section: Natural Antioxidant Therapy For Oxidative Stress-related Eye...mentioning

confidence: 99%

“…The oral administration of curcumin can relieve chronic diabetic macular edema and improve visual acuity [259]. The above reports demonstrate the therapeutic value of natural antioxidants in ophthalmic diseases [248,260].…”

Section: Natural Antioxidant Therapy For Oxidative Stress-related Eye...mentioning

confidence: 99%

The Pathomechanism, Antioxidant Biomarkers, and Treatment of Oxidative Stress-Related Eye Diseases

Hsueh

Chen

Tsao

et al. 2022

IJMS

View full text Add to dashboard Cite

Oxidative stress is an important pathomechanism found in numerous ocular degenerative diseases. To provide a better understanding of the mechanism and treatment of oxidant/antioxidant imbalance-induced ocular diseases, this article summarizes and provides updates on the relevant research. We review the oxidative damage (e.g., lipid peroxidation, DNA lesions, autophagy, and apoptosis) that occurs in different areas of the eye (e.g., cornea, anterior chamber, lens, retina, and optic nerve). We then introduce the antioxidant mechanisms present in the eye, as well as the ocular diseases that occur as a result of antioxidant imbalances (e.g., keratoconus, cataracts, age-related macular degeneration, and glaucoma), the relevant antioxidant biomarkers, and the potential of predictive diagnostics. Finally, we discuss natural antioxidant therapies for oxidative stress-related ocular diseases.

show abstract

Curcumin Metabolite Tetrahydrocurcumin in the Treatment of Eye Diseases

Cited by 30 publications

References 92 publications

Signature of Circulating Biomarkers in Recurrent Non-Infectious Anterior Uveitis. Immunomodulatory Effects of DHA-Triglyceride. A Pilot Study

Signature of Circulating Biomarkers in Recurrent Non-Infectious Anterior Uveitis. Immunomodulatory Effects of DHA-Triglyceride. A Pilot Study

Developmental and lifelong dioxin exposure induces measurable changes in cardiac structure and function in adulthood

The Pathomechanism, Antioxidant Biomarkers, and Treatment of Oxidative Stress-Related Eye Diseases

Contact Info

Product

Resources

About