Curcumin-Loaded γ-Cyclodextrin Liposomal Nanoparticles as Delivery Vehicles for Osteosarcoma

Dhule, Santosh S.; Penfornis, Patrice; Frazier, Trivia; Walker, Ryan W.; Feldman, Joshua; Tan, Grace; Hec, Jibao; Alb, Alina M.; John, Vijay T.; Pochampally, Radhika

doi:10.1201/b22358-10

Cited by 18 publications

(21 citation statements)

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“…Piperine induced increased activity of acidic, neutral and alkaline protease inhibitors as well as that of neutral proteases in the haemolymph of the workers. These enzymes are involved in the mechanism of apoptosis and are essential components of insect resistance barriers (Grzywnowicz et al, 2009;Dhule et al, 2012;Strachecka et al, 2014aStrachecka et al, , 2014b. They also participate in other processes such as phagocytosis, melanization, cellular adhesion, synthesis of cytokines and antimicrobial peptides, enzyme activation and hormonal signalling (Griesch and Vilcinskas, 1998).…”

Section: Discussionmentioning

confidence: 99%

Piperine as a new natural supplement with beneficial effects on the life-span and defence system of honeybees

et al. 2019

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Many factors, including pathogens, environmental change and breeding techniques, affect honeybee immunity/resistance, so substances and natural supplements that enhance it are desired. To eliminate the impact of unknown external factors, in 2016 a cage experiment was conducted under constant laboratory conditions (35 °C, 65% relative humidity). Bees in the control group were fed with sugar dissolved in water at ratio 1:1 ad libitum with no additives, while the other group was fed with sugar syrup (1:1) supplemented with piperine (3 µg/ml) ad libitum. The piperine-treated workers lived 9 days longer compared to the control group. In the piperine-consuming group, protein concentration and the activities of antioxidative enzymes, such as superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and glutathione S-transferase (GST), were higher than in the control group. The activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were also higher in the piperine-treated group. Neutral and acidic proteases inhibitors, as well as neutral protease activities, were higher in the haemolymph of the piperine-treated workers than in untreated bees. Acidic protease activities in the haemolymph were higher in untreated workers only on days 18 and 32. Alkaline protease activities in the control bees were higher from day 10. From 10 days old, the total antioxidant capacity level was significantly higher in the haemolymph of piperine-treated workers. Piperine decreased DNA methylation levels significantly in the older bees. The compound could have the potential to be a natural diet supplement increasing apian resistance to stress factors.

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Section: Discussionmentioning

confidence: 99%

Piperine as a new natural supplement with beneficial effects on the life-span and defence system of honeybees

et al. 2019

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“…Extensive studies showed that liposomal curcumin was the most suitable vehicle to treat various cancer diseases. Dhule et al showed that liposomal curcumin inhibited the growth of the KHOS OS cell line and MCF-7 breast cancer cell line and exhibited a strong anticancer effect in both in vitro and in vivo condition (Dhule et al, 2012). Tian et al studied the antitumor efficiency and the biochemical mechanisms triggered by curcumin liposomes in PC-3 human prostate cancer cells.…”

Section: Liposomesmentioning

confidence: 99%

Nanocurcumin: A Promising Candidate for Therapeutic Applications

2020

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“…A wide range of NDS including SLNs, nanoemulsions, solid dispersions, nanosuspension, PEGylated curcumin NPs, aqueous emulsion, curcumin‐loaded methoxy poly (ethylene glycol)‐ poly (ε‐caprolactone) (mPEG‐PCL) nanoemulsion, aqueous PLGA NPs, pH‐sensitive NPs, curcumin‐encapsulated cellulose NPs, curcumin‐loaded hydrogel, and liposomes have been reported to improve oral bioavailability of curcumin (Khalil et al., 2013; Dhule et al., 2012; Jourghanian et al., 2016; Abbas et al., 2015; Cheng et al., 2019). The earlier findings on curcumin‐loaded NDS were focused on improved stability and bioavailability of loaded curcumin.…”

Section: Nano‐bio Interactions Of Curcumin‐loaded Ndsmentioning

confidence: 99%

Interactions of plant food bioactives‐loaded nano delivery systems at the nano‐bio interface and its pharmacokinetics: An overview

et al. 2022

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Plant food bioactives (PFBs) offer immense health benefits with a greater scope for treating various life‐threatening diseases and lifestyle disorders. Knowing their therapeutic potentials, a lot of research works are being carried out on formulating PFBs‐loaded nano delivery systems (NDSs) to enhance their bioefficacy. However, limited information are available on the interactions occurring at the nano‐bio interface. Therefore, studies on nano‐bio interactions are of immense importance towards designing/formulating effective NDSs for PFBs. Understanding the significance of nano‐bio interface of food bioactive‐loaded NDSs would help us to predict the formation of biocorona as well as the correlation between the nanoparticles and their surrounding environments that are influenced by the NDS's physicochemical properties. The physicochemical characteristics of NDSs like size, shape, and surface charge will decide their fate in the biological fluids and have been discussed in detail. As the bioactives‐loaded NDS enters the gastrointestinal tract, formation of biocorona including protein and enzyme corona at the nano‐bio interface will takes place. Subsequently, the fate of PFBs‐loaded NDSs influences the absorption, distribution, metabolism, and excretion (ADME) processes and thereby its bioavailability, bioefficacy, and biosafety. The current review focuses on understanding the journey of PBFs‐loaded NDSs, the nature of interactions happening at nano‐bio interface, and its pharmacokinetics properties. In addition, a specific case study approach on curcumin‐loaded NDSs, and its reported interactions at nano‐bio interface, including ADME mechanism are comprehensively presented.

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Curcumin-Loaded γ-Cyclodextrin Liposomal Nanoparticles as Delivery Vehicles for Osteosarcoma

Cited by 18 publications

References 1 publication

Piperine as a new natural supplement with beneficial effects on the life-span and defence system of honeybees

Piperine as a new natural supplement with beneficial effects on the life-span and defence system of honeybees

Nanocurcumin: A Promising Candidate for Therapeutic Applications

Interactions of plant food bioactives‐loaded nano delivery systems at the nano‐bio interface and its pharmacokinetics: An overview

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