Curcumin-loaded proniosomal gel as a biofreindly alternative for treatment of ocular inflammation: In-vitro and in-vivo assessment

Aboali, Fatma A.; Habib, Doaa A.; El-Bedaiwy, Heba M.; Farid, Ragwa M.

doi:10.1016/j.ijpharm.2020.119835

Cited by 29 publications

(12 citation statements)

References 57 publications

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“…Increasing the concentration of surfactant resulted in significant particle size reduction. Results are in accordance with those obtained by other authors [ 49 , 50 ]. During the last years, the use of surfactants has been researched for the application in liposomal formulations.…”

Section: Resultssupporting

confidence: 93%

Development of Lactoferrin-Loaded Liposomes for the Management of Dry Eye Disease and Ocular Inflammation

et al. 2021

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Dry eye disease (DED) is a high prevalent multifactorial disease characterized by a lack of homeostasis of the tear film which causes ocular surface inflammation, soreness, and visual disturbance. Conventional ophthalmic treatments present limitations such as low bioavailability and side effects. Lactoferrin (LF) constitutes a promising therapeutic tool, but its poor aqueous stability and high nasolacrimal duct drainage hinder its potential efficacy. In this study, we incorporate lactoferrin into hyaluronic acid coated liposomes by the lipid film method, followed by high pressure homogenization. Pharmacokinetic and pharmacodynamic profiles were evaluated in vitro and ex vivo. Cytotoxicity and ocular tolerance were assayed both in vitro and in vivo using New Zealand rabbits, as well as dry eye and anti-inflammatory treatments. LF loaded liposomes showed an average size of 90 nm, monomodal population, positive surface charge and a high molecular weight protein encapsulation of 53%. Biopharmaceutical behaviour was enhanced by the nanocarrier, and any cytotoxic effect was studied in human corneal epithelial cells. Developed liposomes revealed the ability to reverse dry eye symptoms and possess anti-inflammatory efficacy, without inducing ocular irritation. Hence, lactoferrin loaded liposomes could offer an innovative nanotechnological tool as suitable approach in the treatment of DED.

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Section: Resultssupporting

confidence: 93%

Development of Lactoferrin-Loaded Liposomes for the Management of Dry Eye Disease and Ocular Inflammation

et al. 2021

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“…Content uniformity of all optimized formulations were found to be within the range of 95–110% which showed that CUR and PEG-CUR was uniformly distributed in ointments as previously reported by Yin, X. et al ., [ 22 ]. Cremophore (CR) was finally selected as a penetration enhancer due to its hydrophilicity and used in ophthalmic ointment as already reported by Aboali et al ., [ 23 ]. PEG-CUR ointment with cremophore showed enhance solubility and permeation.…”

Section: Resultsmentioning

confidence: 99%

Improved solubility and corneal permeation of PEGylated curcumin complex used for the treatment of ophthalmic bacterial infections

et al. 2022

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Naturally occurring curcumin can be used for the treatment of corneal bacterial infections with its limitation of poor solubility. Aim of the present study was to enhance solubility and permeation of curcumin for the treatment of corneal bacterial infections. For increasing solubility, curcumin and polyethylene glycol (PEG 6000) complex (1:3) was prepared by fusion melting method. Phase solubility studies were used for the calculation of Gibbs free energy of curcumin. Central composite rotatable design (CCRD) was applied for optimization of Curcumin (CUR), PEGylated Curcumin (PEG-CUR), penetration enhancer cremophore (CR). Optimized ointments were further evaluated by mucous permeation, membrane permeability and cell toxicity studies by Transwell cell, ussing chamber and Caco-2 cells respectively. Antibacterial test was also performed by agar well diffusion method. Solubility of PEG-CUR was increased up to 93±3.2% as compared to pure curcumin and content uniformity was in the range of 95–110%. Curcumin permeation from PEG-CUR ointment was increased up to 12 folds. No toxicity of Caco-2 cells for PEG-CUR even after 24h was observed. Activity index of pure CUR, PEG-CUR ointment with or without CR against S. aureus and P. aeruginosa was 97±2.3, 96±1.6, 95±2.5% respectively. Ointment with solubility enhanced PEG-CUR and cremophore can be used as a promising tool for the treatment of corneal bacterial infections.

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“…These results reveal that this nano‐gel has a high biocompatibility with improved solubility and stability of Cur in the development of gelling ophthalmic drug formulations. In an in vivo study, Aboali, Habib, Elbedaiwy, and Farid (2020) confirmed that Cur proniosomal gel can be applied as a natural and potential biofreindly carrier for the treatment of ocular inflammation by inhibiting the expression of induced inflammatory biomarkers. In another work, the therapeutic effects of a thermosensitive hydrogel of latanoprost‐Cur nanocarriers were studied as a co‐delivery system on intraocular pressure in glaucoma.…”

Section: Cur Nanoformulations As Promising Strategies For the Treatme...mentioning

confidence: 92%

A comprehensive review of the therapeutic potential of curcumin nanoformulations

Khezri

Saeedi

Mohammadamini

et al. 2021

Phytotherapy Research

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Today, due to the prevalence of various diseases such as the novel coronavirus (SARS-CoV-2), diabetes, central nervous system diseases, cancer, cardiovascular disorders, and so on, extensive studies have been conducted on therapeutic properties of natural and synthetic agents. A literature review on herbal medicine and commercial products in the global market showed that curcumin (Cur) has many therapeutic benefits compared to other natural ingredients. Despite the unique properties of Cur, its use in clinical trials is very limited. The poor biopharmaceutical properties of Cur such as short half-life in plasma, low bioavailability, poor absorption, rapid metabolism, very low solubility (at acidic and physiological pH), and the chemical instability in body fluids are major concerns associated with the clinical applications of Cur.Recently, nanoformulations are emerging as approaches to develop and improve the therapeutic efficacy of various drugs. Many studies have shown that Cur nanoformulations have tremendous therapeutic potential against various diseases such as SARS-CoV-2, cancer, inflammatory, osteoporosis, and so on. These nanoformulations can inhibit many diseases through several cellular and molecular mechanisms. However, successful long-term clinical results are required to confirm their safety and clinical efficacy. The present review aims to update and explain the therapeutic potential of Cur nanoformulations.

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Curcumin-loaded proniosomal gel as a biofreindly alternative for treatment of ocular inflammation: In-vitro and in-vivo assessment

Cited by 29 publications

References 57 publications

Development of Lactoferrin-Loaded Liposomes for the Management of Dry Eye Disease and Ocular Inflammation

Development of Lactoferrin-Loaded Liposomes for the Management of Dry Eye Disease and Ocular Inflammation

Improved solubility and corneal permeation of PEGylated curcumin complex used for the treatment of ophthalmic bacterial infections

A comprehensive review of the therapeutic potential of curcumin nanoformulations

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