Curcumin-loaded polysaccharides-based complex particles obtained by polyelectrolyte complexation and ionic gelation. I-Particles obtaining and characterization

Iurciuc-Tincu, Camelia-Elena; Atanase, Leonard Ionuţ; Ochiuz, Lăcrămioara; Jérôme, Christine; Sol, Vincent; Martin, Patrick; Popa, Marcel

doi:10.1016/j.ijbiomac.2019.12.247

Cited by 65 publications

(34 citation statements)

References 58 publications

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“…In this field, a particular phytoherapeutic, curcumin, has exhibited a series of attractive properties such as antioxidant and anti-inflammatory effects in addition to being favorable for wound healing [ 23 , 24 ]. There are some reports about the successful entrapment and release of curcumin by micro and nanoparticles made of various materials, PHAs, among others [ 22 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Integration of Mesoporous Bioactive Glass Nanoparticles and Curcumin into PHBV Microspheres as Biocompatible Composite for Drug Delivery Applications

et al. 2021

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Bioactive glasses (BGs) are being increasingly considered for biomedical applications. One convenient approach to utilize BGs in tissue engineering and drug delivery involves their combination with organic biomaterials in order to form composites with enhanced biocompatibility and biodegradability. In this work, mesoporous bioactive glass nanoparticles (MBGN) have been merged with polyhydroxyalkanoate microspheres with the purpose to develop drug carriers. The composite carriers (microspheres) were loaded with curcumin as a model drug. The toxicity and delivery rate of composite microspheres were tested in vitro, reaching a curcumin loading efficiency of over 90% and an improving of biocompatibility of different concentrations of MBGN due to its administrations through the composite. The composite microspheres were tested in terms of controlled release, biocompatibility and bioactivity. Our results demonstrate that the composite microspheres can be potentially used in biomedicine due to their dual effects: bioactivity (due to the presence of MBGN) and curcumin release capability.

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Section: Introductionmentioning

confidence: 99%

Integration of Mesoporous Bioactive Glass Nanoparticles and Curcumin into PHBV Microspheres as Biocompatible Composite for Drug Delivery Applications

et al. 2021

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“…In order to improve the therapeutic efficiency and to reduce the side effects of these highly hydrophobic compounds, Cur and 5-FU were loaded in various PMs which are readily soluble in aqueous media and have an improved dosing, especially in the case of intravenous administration [ 19 , 20 , 21 , 22 ]. However, as far as one can tell from the literature, no studies exist concerning the loading of these drugs in pH-sensitive nanomicellar systems based on poly(2-vinyl pyridine)-b-poly(ethylene oxide) (P2VP-b-PEO) block copolymers.…”

Section: Introductionmentioning

confidence: 99%

Drug Delivery System Based on pH-Sensitive Biocompatible Poly(2-vinyl pyridine)-b-poly(ethylene oxide) Nanomicelles Loaded with Curcumin and 5-Fluorouracil

et al. 2020

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Smart polymeric micelles (PMs) are of practical interest as nanocarriers for the encapsulation and controlled release of hydrophobic drugs. Two hydrophobic drugs, naturally-based curcumin (Cur) and synthetic 5-fluorouracil (5-FU), were loaded into the PMs formed by a well-defined pH-sensitive poly(2-vinyl pyridine)-b-poly(ethylene oxide) (P2VP90-b-PEO398) block copolymer. The influence of the drug loading on the micellar sizes was investigated by dynamic light scattering (DLS) and it appears that the size of the PMs increases from around 60 to 100 nm when Cur is loaded. On the contrary, the loading of the 5-FU has a smaller effect on the micellar sizes. This difference can be attributed to higher molar mass of Cur with respect to 5-FU but also to higher loading efficiency of Cur, 6.4%, compared to that of 5-FU, 5.8%. In vitro drug release was studied at pH 2, 6.8, and 7.4, and it was observed that the pH controls the release of both drugs. At pH 2, where the P2VP sequences from the “frozen-in” micellar core are protonated, the drug release efficiencies exceed 90%. Moreover, it was demonstrated, by in vitro assays, that these PMs are hemocompatible and biocompatible. Furthermore, the PMs protect the Cur against the photo-degradation, whereas the non-ionic PEO corona limits the adsorption of bovine serum albumin (BSA) protein on the surface. This study demonstrates that these pH-sensitive PMs are suitable for practical utilization as human-safe and smart, injectable drug delivery systems.

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“…An ideal drug carrier must be biocompatible, biodegradable, non-toxic, and have the capability to release the loaded active principles at the desired site of action. Until now, a large number of inorganic and organic materials, which have been formulated as liposomes, organic and inorganic nanoparticles, and hydrogels, have been used as promising drug carriers [1][2][3][4][5][6][7][8]. However, there is an increasing interest in using natural biopolymers for the elaboration of different types of drug delivery systems (DDS) due to their abundance in nature and characteristic features, such as sustainability, biocompatibility, and biodegradability [9,10].…”

Section: Introductionmentioning

confidence: 99%

Micellar Drug Delivery Systems Based on Natural Biopolymers

Atanase

2021

Polymers

146

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The broad diversity of structures and the presence of numerous functional groups available for chemical modifications represent an enormous advantage for the development of safe, non-toxic, and cost-effective micellar drug delivery systems (DDS) based on natural biopolymers, such as polysaccharides, proteins, and peptides. Different drug-loading methods are used for the preparation of these micellar systems, but it appeared that dialysis is generally recommended, as it avoids the formation of large micellar aggregates. Moreover, the preparation method has an important influence on micellar size, morphology, and drug loading efficiency. The small size allows the passive accumulation of these micellar systems via the permeability and retention effect. Natural biopolymer-based micellar DDS are high-value biomaterials characterized by good compatibility, biodegradability, long blood circulation time, non-toxicity, non-immunogenicity, and high drug loading, and they are biodegraded to non-toxic products that are easily assimilated by the human body. Even if some recent studies reported better antitumoral effects for the micellar DDS based on polysaccharides than for commercial formulations, their clinical use is not yet generalized. This review is focused on the studies from the last decade concerning the preparation as well as the colloidal and biological characterization of micellar DDS based on natural biopolymers.

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Curcumin-loaded polysaccharides-based complex particles obtained by polyelectrolyte complexation and ionic gelation. I-Particles obtaining and characterization

Cited by 65 publications

References 58 publications

Integration of Mesoporous Bioactive Glass Nanoparticles and Curcumin into PHBV Microspheres as Biocompatible Composite for Drug Delivery Applications

Integration of Mesoporous Bioactive Glass Nanoparticles and Curcumin into PHBV Microspheres as Biocompatible Composite for Drug Delivery Applications

Drug Delivery System Based on pH-Sensitive Biocompatible Poly(2-vinyl pyridine)-b-poly(ethylene oxide) Nanomicelles Loaded with Curcumin and 5-Fluorouracil

Micellar Drug Delivery Systems Based on Natural Biopolymers

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