Curcumin-loaded nanoemulsions produced by the emulsion inversion point (EIP) method: An evaluation of process parameters and physico-chemical stability

Borrin, Thaís Ribeiro; Georges, Eduarda L.; Moraes, Izabel Cristina Freitas; Pinho, Samantha C.

doi:10.1016/j.jfoodeng.2015.08.012

Cited by 82 publications

(49 citation statements)

References 55 publications

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“…), but it was recently investigated by Borrin et al . () for the production of curcumin‐loaded nanoemulsions. These nanodispersions, with average diameters in the range 200–250 nm, showed high physicochemical stability over 60 days of storage, and were capable of preserving 70%–75% of the initial amount of encapsulated curcumin.…”

Section: Introductionmentioning

confidence: 99%

Technological and sensory evaluation of pineapple ice creams incorporating curcumin‐loaded nanoemulsions obtained by the emulsion inversion point method

Borrin

Georges

Brito‐Oliveira

et al. 2017

Int J of Dairy Tech

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This study evaluated the feasibility of incorporating curcumin‐loaded nanoemulsions (CLNE) produced by the emulsion inversion point method in pineapple ice creams to replace artificial yellow dyes. For this purpose, ice creams with formulations: A (pineapple flavour commercial mix), B (partial replacement of commercial mix by CLNE), C (complete replacement of commercial mix by CLNE) and D (complete replacement of commercial mix by nonencapsulated curcumin) were characterized. Results showed that CLNE incorporation was a feasible alternative for reducing the use of artificial dyes, as the ice creams showed similar physicochemical and rheological properties, and formulations A and B had similar sensory acceptance.

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Section: Introductionmentioning

confidence: 99%

Technological and sensory evaluation of pineapple ice creams incorporating curcumin‐loaded nanoemulsions obtained by the emulsion inversion point method

Borrin

Georges

Brito‐Oliveira

et al. 2017

Int J of Dairy Tech

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“…The presence of glycerol strongly influenced the formation of nanoemulsions by PIC. 46 Upon addition of water, the normal tendency of Tween 80 molecules was to migrate to a water-rich environment and to accommodate themselves in an oil-water interface. The presence of glycerol lowered the solubility of Tween 80 in the aqueous phase.…”

Section: Glycerol Weight Ratiomentioning

confidence: 99%

“…59 Control of the migration rate of Tween 80 molecules from the oil to aqueous phase was also controlled by the influence of glycerol on their solubility, as well as by the increase in viscosity of the aqueous phase with greater amounts of glycerol. 46 Formation of emulsions was influenced by an equivalence between the two main mechanisms: droplet disruption and droplet coalescence. The surfactants play major roles in the deformation and breakup of droplets.…”

Section: Glycerol Weight Ratiomentioning

confidence: 99%

“…High glycerol concentrations may dehydrate the polar heads of polysorbate molecules too quickly and intensely, 29 leading to high reduction in the hydrophilic-lipophilic balance of the surfactant and preventing their proper accommodation in the oil-water interface. 46 Glycerol contains three hydroxyl groups; therefore, an increase in glycerol concentration accompanied by a reduction in TW80 concentration made spontaneous breakup of the oil-water interface more difficult without a decrease in interfacial tension. Areas of O/W nanoemulsion zones are known to be dependent on surfactant contention.…”

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confidence: 99%

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Formulation, development, and optimization of a novel octyldodecanol-based nanoemulsion for transdermal delivery of ceramide IIIB

Su¹,

Yang²,

Wang³

et al. 2017

IJN

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This research aimed to develop and optimize a nanoemulsion-based formulation containing ceramide IIIB using phase-inversion composition for transdermal delivery. The effects of ethanol, propylene glycol (PG), and glycerol in octyldodecanol and Tween 80 systems on the size of the nanoemulsion region in the phase diagrams were investigated using water titration. Subsequently, ceramide IIIB loading was kept constant (0.05 wt%), and the proposed formulation and conditions were optimized via preliminary screening and experimental design. Factors such as octyldodecanol/(Tween 80:glycerol) weight ratio, water content, temperature, addition rate, and mixing rate were investigated in the preliminary screening experiment. Response surface methodology was employed to study the effect of water content (30%–70%, w/w), mixing rate (400–720 rpm), temperature (20°C–60°C), and addition rate (0.3–1.8 mL/min) on droplet size and polydispersity index. The mathematical model showed that the optimum formulation and conditions for preparation of ceramide IIIB nanoemulsion with desirable criteria were a temperature of 41.49°C, addition rate of 1.74 mL/min, water content of 55.08 wt%, and mixing rate of 720 rpm. Under optimum formulation conditions, the corresponding predicted response values for droplet size and polydispersity index were 15.51 nm and 0.12, respectively, which showed excellent agreement with the actual values (15.8 nm and 0.108, respectively), with no significant ( P >0.05) differences.

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“…Emulsion-based delivery systems can be used efficiently to optimize curcumin unfavorable physical-chemical features [22,23,[25][26][27][28]. New self-microemulsifying drug delivery systems (SMEDDS) have been successfully developed to improve the solubility, oral absorption and bioavailability of curcumin.…”

Section: Microemulsions and Nanoemulsionsmentioning

confidence: 99%

Modern drug delivery strategies applied to natural active compounds

Puglia

Lauro

Tirendi

et al. 2016

Expert Opinion on Drug Delivery

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Colloidal drug delivery systems (CDDSs) are innovative carriers that have been studied in pharmaceutical field from many years to overcome unfavorable physical and chemical features of synthetic drugs. Recently the use of CDDS as carriers for phytochemicals has seen an exponential increase which, in some cases, has led to the rediscovery of ancient and forgotten natural molecules. Area covered: This article focuses on the main features of CDDS, particularly micro- and nanoemulsions, vesicular carriers and micro- and nanoparticles, loaded with natural active compounds. A detailed review of the literature is presented, introducing the importance of these systems in terms of their capability to optimize the stability of phytochemicals, their absorption through biological membranes and their bioavailability. Expert opinion: The delivery of phytochemicals is problematic due to poor solubility, poor permeability, low bioavailability, instability in biological milieu and extensive first-pass metabolism. Global research efforts investigating nanotechnology have attempted to overcome these limitations rediscovering and, in some cases, 'discovering ex novo' unexpected virtues and benefits associated to these compounds. The 'nanotechnological approach' can definitely enhance the pharmacokinetics and therapeutic index of natural active compounds and improve their performance in therapy.

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Curcumin-loaded nanoemulsions produced by the emulsion inversion point (EIP) method: An evaluation of process parameters and physico-chemical stability

Cited by 82 publications

References 55 publications

Technological and sensory evaluation of pineapple ice creams incorporating curcumin‐loaded nanoemulsions obtained by the emulsion inversion point method

Technological and sensory evaluation of pineapple ice creams incorporating curcumin‐loaded nanoemulsions obtained by the emulsion inversion point method

Formulation, development, and optimization of a novel octyldodecanol-based nanoemulsion for transdermal delivery of ceramide IIIB

Modern drug delivery strategies applied to natural active compounds

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