Curcumin-loaded nanoemulsion improves haemorrhagic stroke recovery in wistar rats

Marques, M S; Cordeiro, Marcos Freitas; Marinho, Marcelo Augusto Germani; Vian, C.O.; Vaz, Gustavo Richter; Alves, Brunna Suélli de Souza; Jardim, Rodrigo Desessards; Hort, Mariana Appel; Dora, Cristiana Lima; Horn, Ana Paula

doi:10.1016/j.brainres.2020.147007

Cited by 29 publications

(15 citation statements)

References 75 publications

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“…Other approaches such as the incorporation of curcumin as nanoparticles, micelles, or liposomes could increase the systemic bioavailability of curcumin. For example, curcumin nanoemulsion reduces behavioral deficits and the size of the hematoma in ICH-challenged rats . Similarly, curcumin nanomicelle attenuates oxidative stress and neuroinflammation following global cerebral ischemic injury in rats .…”

Section: Limitations and Future Perspectives Of Curcumin In Cerebral ...mentioning

confidence: 99%

“…For example, curcumin nanoemulsion reduces behavioral deficits and the size of the hematoma in ICH-challenged rats. 99 Similarly, curcumin nanomicelle attenuates oxidative stress and neuroinflammation following global cerebral ischemic injury in rats. 100 In addition, curcumin containing surface-functionalized exosomes suppresses cellular apoptosis and neuroinflammatory response in mice brain of focal cerebral ischemia.…”

Section: Limitations and Future Perspectives Of Curcumin In Cerebral ...mentioning

confidence: 99%

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Neuroprotective Effects of Curcumin in Cerebral Ischemia: Cellular and Molecular Mechanisms

Subedi

Gaire

2021

ACS Chem. Neurosci.

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Despite being a major global health concern, cerebral ischemia/stroke has limited therapeutic options. Tissue plasminogen activator (tPA) is the only available medication to manage acute ischemic stroke, but this medication is associated with adverse effects and has a narrow therapeutic time window. Curcumin, a polyphenol that is abundantly present in the rhizome of the turmeric plant (Curcuma longa), has shown promising neuroprotective effects in animal models of neurodegenerative diseases, including cerebral ischemia. In the central nervous system (CNS), neuroprotective effects of curcumin have been experimentally validated in Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and cerebral ischemia. Curcumin can exert pleiotropic effects in the postischemic brain including antioxidant, anti-inflammatory, antiapoptotic, vasculoprotective, and direct neuroprotective efficacies. Importantly, neuroprotective effects of curcumin has been reported in both ischemic and hemorrhagic stroke models. A broad-spectrum neuroprotective efficacy of curcumin suggested that curcumin can be an appealing therapeutic strategy to treat cerebral ischemia. In this review, we aimed to address the pharmacotherapeutic potential of curcumin in cerebral ischemia including its cellular and molecular mechanisms of neuroprotection revealing curcumin as an appealing therapeutic candidate for cerebral ischemia.

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Section: Limitations and Future Perspectives Of Curcumin In Cerebral ...mentioning

confidence: 99%

Section: Limitations and Future Perspectives Of Curcumin In Cerebral ...mentioning

confidence: 99%

Neuroprotective Effects of Curcumin in Cerebral Ischemia: Cellular and Molecular Mechanisms

Subedi

Gaire

2021

ACS Chem. Neurosci.

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“…In a cerebral palsy rabbit model, intravenous treatment of dendrimer-based N-acetyl- l -cysteine (NAC) [ 299 ], a glutathione precursor with antioxidant and anti-inflammatory properties [ 300 ], reduced neuroinflammation and neurological injury, and improved motor function. In general, formulating antioxidants in nanocarriers has enhanced their efficacy due to better stability and/or improved transport to the CNS than free antioxidants [ 301 , 302 , 303 , 304 , 305 , 306 , 307 , 308 , 309 , 310 , 311 , 312 , 313 , 314 , 315 , 316 , 317 , 318 , 319 , 320 , 321 , 322 , 323 , 324 , 325 , 326 , 327 ]. Nanocurcumin has been evaluated as an add-on therapy to Riluzole in a pilot randomized clinical trial for safety and efficacy in ALS [ 272 ] and AD patients as dietary supplements [ 274 ].…”

Section: Antioxidant-based Nanotherapymentioning

confidence: 99%

Antioxidant Therapy in Oxidative Stress-Induced Neurodegenerative Diseases: Role of Nanoparticle-Based Drug Delivery Systems in Clinical Translation

et al. 2022

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Free radicals are formed as a part of normal metabolic activities but are neutralized by the endogenous antioxidants present in cells/tissue, thus maintaining the redox balance. This redox balance is disrupted in certain neuropathophysiological conditions, causing oxidative stress, which is implicated in several progressive neurodegenerative diseases. Following neuronal injury, secondary injury progression is also caused by excessive production of free radicals. Highly reactive free radicals, mainly the reactive oxygen species (ROS) and reactive nitrogen species (RNS), damage the cell membrane, proteins, and DNA, which triggers a self-propagating inflammatory cascade of degenerative events. Dysfunctional mitochondria under oxidative stress conditions are considered a key mediator in progressive neurodegeneration. Exogenous delivery of antioxidants holds promise to alleviate oxidative stress to regain the redox balance. In this regard, natural and synthetic antioxidants have been evaluated. Despite promising results in preclinical studies, clinical translation of antioxidants as a therapy to treat neurodegenerative diseases remains elusive. The issues could be their low bioavailability, instability, limited transport to the target tissue, and/or poor antioxidant capacity, requiring repeated and high dosing, which cannot be administered to humans because of dose-limiting toxicity. Our laboratory is investigating nanoparticle-mediated delivery of antioxidant enzymes to address some of the above issues. Apart from being endogenous, the main advantage of antioxidant enzymes is their catalytic mechanism of action; hence, they are significantly more effective at lower doses in detoxifying the deleterious effects of free radicals than nonenzymatic antioxidants. This review provides a comprehensive analysis of the potential of antioxidant therapy, challenges in their clinical translation, and the role nanoparticles/drug delivery systems could play in addressing these challenges.

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“…This investigation indicated that Cur‐PNIPAM nanoparticles can be utilized as a potential neuroprotective agent for treating cerebral ischemia. In another in vivo study, Marques et al (2020) demonstrated that nano‐emulsified Cur can be used to improve hemorrhagic stroke with a mechanism of decreased oxidative damage in the animal model. In a study, Zhang, Zhang, Du, Wang, and Chi (2020) investigated the properties of Cur‐silk fibroin nanocarriers for therapy of ischemic stroke.…”

Section: Cur Nanoformulations As Promising Strategies For the Treatme...mentioning

confidence: 99%

A comprehensive review of the therapeutic potential of curcumin nanoformulations

Khezri

Saeedi

Mohammadamini

et al. 2021

Phytotherapy Research

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Today, due to the prevalence of various diseases such as the novel coronavirus (SARS-CoV-2), diabetes, central nervous system diseases, cancer, cardiovascular disorders, and so on, extensive studies have been conducted on therapeutic properties of natural and synthetic agents. A literature review on herbal medicine and commercial products in the global market showed that curcumin (Cur) has many therapeutic benefits compared to other natural ingredients. Despite the unique properties of Cur, its use in clinical trials is very limited. The poor biopharmaceutical properties of Cur such as short half-life in plasma, low bioavailability, poor absorption, rapid metabolism, very low solubility (at acidic and physiological pH), and the chemical instability in body fluids are major concerns associated with the clinical applications of Cur.Recently, nanoformulations are emerging as approaches to develop and improve the therapeutic efficacy of various drugs. Many studies have shown that Cur nanoformulations have tremendous therapeutic potential against various diseases such as SARS-CoV-2, cancer, inflammatory, osteoporosis, and so on. These nanoformulations can inhibit many diseases through several cellular and molecular mechanisms. However, successful long-term clinical results are required to confirm their safety and clinical efficacy. The present review aims to update and explain the therapeutic potential of Cur nanoformulations.

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Curcumin-loaded nanoemulsion improves haemorrhagic stroke recovery in wistar rats

Cited by 29 publications

References 75 publications

Neuroprotective Effects of Curcumin in Cerebral Ischemia: Cellular and Molecular Mechanisms

Neuroprotective Effects of Curcumin in Cerebral Ischemia: Cellular and Molecular Mechanisms

Antioxidant Therapy in Oxidative Stress-Induced Neurodegenerative Diseases: Role of Nanoparticle-Based Drug Delivery Systems in Clinical Translation

A comprehensive review of the therapeutic potential of curcumin nanoformulations

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