Curcumin-loaded mesoporous silica nanoparticles for drug delivery: synthesis, biological assays and therapeutic potential – a review

Abstract

Curcumin-loaded mesoporous silica nanoparticles (MSNs) have shown promise as drug delivery systems to address the limited pharmacokinetic characteristics of curcumin.

The Exploitation of pH-Responsive Eudragit-Coated Mesoporous Silica Nanostructures in the Repurposing of Terbinafine Hydrochloride for Targeted Colon Cancer Inhibition: Design Optimization, In Vitro Characterization, and Cytotoxicity Assessment

“…Additionally, the nano formulations’ small size has exhibited a major role in cellular ingestion. The high surface area and pore volume of SBA-15 could provide more contact points for the drug–cell interactions, increasing the uptake of drugs by cancer cells and improving their cytotoxicity [ 56 ].…”

Ameliorating Old Drugs with New Tricks in the Nano Realms

“…With their fascinating properties, mesoporous silica nanoparticles have turned the wheel of the drug delivery arena into new light. Their sizes and loading capacity can be tuned as preferred, ranging from 2 to 50 nm and with a pore volume greater than 0.6 cm 3 g –1 . , They are suitable not only for drug delivery but also for dissolution enhancement. Depending on the synthesis approach, MSNs can be customized to carry hydrophobic and hydrophilic drugs.…”

Photostabilities and anti-tumor effects of curcumin and curcumin-loaded polydopamine nanoparticles

“…Curcumin is currently one of the most widely used natural synthetic drugs in the world. [1][2][3] It is a pigment molecule with photosensitive activity and has been proven to have effects such as in aging and senescence, 4,5 food coloring, 6 free radical scavenging, 10 lipid-lowering, 11 and as an anti-inammatory, 7 antioxidant, 8,9 antibacterial, 12 and anticancer agent. 13,14 Curcumin mediated photodynamic technology has been applied in many industries, which is efficient and safety.…”