Curcumin loaded mesoporous silica: an effective drug delivery system for cancer treatment

Kotcherlakota, Rajesh; Barui, Ayan Kumar; Prashar, Sanjiv; Fajardo, Mariano; Briones, David; Rodríguez-Diéguez, Antonio; Patra, Chitta Ranjan; Gómez‐Ruiz, Santiago

doi:10.1039/c5bm00552c

Cited by 114 publications

(61 citation statements)

References 43 publications

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“…With regard to the TGA thermogram of IBU, it exhibited one major step of weight loss covering the temperature ranges of about 180-250°C. It is also documented that the difference in weight percent between the drug-loaded nanoparticles and the placebo nanoparticles can give an approximate indication of the DL percentage [27]. In this study, the current TGA thermogram (Fig.…”

Section: Thermogravimetric Analysismentioning

confidence: 53%

Encapsulation of Ibuprofen Into Solid Lipid Nanoparticles for Controlled and Sustained Release Using Emulsification Solvent Evaporation Technique

Omwoyo

Moloto

2019

Asian J Pharm Clin Res

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Objective: The objective of the study was to encapsulate ibuprofen (IBU) into solid lipid nanoparticles (SLNs) for enhanced dissolution and achieving a sustained and controlled release of the drug from the nanocarrier. Methods: IBU loaded nanoparticles were prepared by emulsification solvent evaporation technique and characterized by Fourier Transform Infrared spectroscopy, Thermogravimetric Analysis, X-ray diffraction (XRD), and transmission electron microscopy. Release kinetics on the drug-loaded nanoparticles was carried out in phosphate buffer pH 6.8 using pharma test dissolution apparatus adopting shaking basket method at 37°C. Results: The optimized IBU-loaded SLNs had a particle size of 76.40 nm, polydispersity index of 0.275, and zeta potential of −41.3 mV. The encapsulation efficiency (EE) and DL were 99.73% and 2.31%, respectively. The Fourier transform infrared spectroscopy (FTIR) spectra confirmed successful encapsulation of the drug inside the nanocarrier as only peaks responsible for the emulsifier and the binder could be identified. This corroborated well with XRD spectra which showed a completely amorphous state of the drug-loaded nanoparticles as compared to the crystalline nature of the pure drug. The IBU-SLNs showed a release profile of up to 8 h which is a great improvement from other reported works. The drug release pattern of IBU-SLNs was best fitted with Higuchi square root model and followed the Higuchi drug release kinetics. Korsmeyer-Peppas model confirmed a non-Fickian diffusion model for the release of the drug from the matrix system. Conclusion: IBU-loaded SLNs were successfully prepared which had a sustained and controlled release. It was observed that the release of the drug from the matrix was diffusion controlled and time dependent.

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Section: Thermogravimetric Analysismentioning

confidence: 53%

Encapsulation of Ibuprofen Into Solid Lipid Nanoparticles for Controlled and Sustained Release Using Emulsification Solvent Evaporation Technique

Omwoyo

Moloto

2019

Asian J Pharm Clin Res

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“…The amount (%) of curcumin released from the PU organogel during immersion in water at 37 °C was determined from in situ monitoring of the maximum absorbance of the drug molecule ( λ max = 430 nm) . Figure (a) shows the cumulative profile release from PUc1.0 (curcumin loaded 1 wt%) as a function of time.…”

Section: Resultsmentioning

confidence: 99%

One‐step formation of polyurea gel as a multifunctional approach for biological and environmental applications

Bonattini

Paula

Jesus

et al. 2020

Polymer International

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This work presents a facile one‐pot fabrication of polyurea (PU) organogels based on polyetheramine (PEO, Jeffamine ED‐2003) and a crosslinker hexamethylene diisocyanate trimer (HDI) which were subsequently used as a drug carrier to incorporate a curcumin hydrophobic molecule in aqueous conditions and for removal of an anionic pollutant in water. PU can be obtained in different shapes with easy control of film thickness with high transparency, flexibility and homogeneous dispersion of curcumin in the matrix. Due to the hydrophilic nature of PEO a high swelling degree was demonstrated by the PU gel. The phase separated domains and the temperature's influence on the system's structural order/disorder were examined by small‐angle X‐ray scattering, showing a more PU ordered system (interface between hard and soft segments) after decreasing the temperature to −90 °C. The presence of curcumin in the structure of PU was confirmed by Fourier transform infrared, photoluminescence and release studies. A highly efficient removal of Congo red dye from aqueous solution using PU as adsorbent was observed. Moreover, the effect of unloaded and curcumin‐loaded PU gels was evaluated on Schistosoma mansoni adult worms. Detailed in vitro cell viability experiments showed the biocompatibility of loaded and unloaded PU gels. The easy processability of the multifunctional PU shows that it has promising applications as transdermal and soft tissue implantable delivery devices for a large number of poorly water‐soluble drugs and as an efficient adsorbent for removal of organic dyes; it can also be used in the future in dermatological treatments against malignant melanoma. © 2020 Society of Chemical Industry

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“…In addition, it was reported that a series of mesoporous silica material-loaded CUR exhibited higher oral bioavailability and cellular uptake and significantly increased A549, MCF-7 and B16F10 cell apoptosis compared to CUR. [30][31][32] A novel drug carrier composed of sodium alginate, hydroxyapatite bilayer-coated iron oxide nanoparticle composite (IONP/HAp-NaAlg) was synthetized via the co-precipitation approach and used to delivery CUR over 7 days. 33 CUR encapsulated in polymeric nanoparticles showed higher solubility and enhanced bioavailability.…”

Section: Introductionmentioning

confidence: 99%

Liposomal curcumin and its application in cancer

Feng¹,

Wei²,

Lee³

et al. 2017

IJN

286

197

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Curcumin (CUR) is a yellow polyphenolic compound derived from the plant turmeric. It is widely used to treat many types of diseases, including cancers such as those of lung, cervices, prostate, breast, bone and liver. However, its effectiveness has been limited due to poor aqueous solubility, low bioavailability and rapid metabolism and systemic elimination. To solve these problems, researchers have tried to explore novel drug delivery systems such as liposomes, solid dispersion, microemulsion, micelles, nanogels and dendrimers. Among these, liposomes have been the most extensively studied. Liposomal CUR formulation has greater growth inhibitory and pro-apoptotic effects on cancer cells. This review mainly focuses on the preparation of liposomes containing CUR and its use in cancer therapy.

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Curcumin loaded mesoporous silica: an effective drug delivery system for cancer treatment

Cited by 114 publications

References 43 publications

Encapsulation of Ibuprofen Into Solid Lipid Nanoparticles for Controlled and Sustained Release Using Emulsification Solvent Evaporation Technique

Encapsulation of Ibuprofen Into Solid Lipid Nanoparticles for Controlled and Sustained Release Using Emulsification Solvent Evaporation Technique

One‐step formation of polyurea gel as a multifunctional approach for biological and environmental applications

Liposomal curcumin and its application in cancer

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