Curcumin-loaded layer-by-layer folic acid and casein coated carboxymethyl cellulose/casein nanogels for treatment of skin cancer

Priya, P. Gomathi; Raj, Rishi; Vasanthakumar, V.; Raj, V.

doi:10.1016/j.arabjc.2017.07.010

Cited by 77 publications

(47 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result is in agreement with a similar study investigating the thermal properties of curcumin in amorphous solid dispersions using hydroxypropyl methylcellulose (HPMC) as a polymeric matrix. 38,39 The physical mixture also showed a single peak observed at a higher temperature (220°C), which could be explained by the hot melting materials during the heating process, resulting in a homogenous dispersion. This was supported by further XRD data analysis that confirmed this suggestion.…”

Section: Differential Thermal Analysismentioning

confidence: 91%

<p>Characterization and Dissolution Study of Micellar Curcumin-Spray Dried Powder for Oral Delivery</p>

Wijiani¹,

Isadiartuti²,

Rijal³

et al. 2020

IJN

View full text Add to dashboard Cite

Introduction: Curcumin faces a major challenge in clinical use due to its poor aqueous solubility, which affects its bioavailability over oral use. The present study was carried out to overcome this problem. Methods: An amorphous micellar curcumin-spray dried powder (MC-SDP) with selfassembled casein was prepared by the addition of sucrose as a protectant. The dry powder of curcumin-loaded micelles was obtained by a spray-drying technique in the presence of sucrose as a protectant. The MC-SDP in the form of dry powder was further developed into tablets to investigate the dissolution profile. The physical properties of preformed powder were characterized by differential thermal analysis (DTA), X-ray diffraction (XRD), and scanning electron microscopy (SEM). Quantitative analysis in the form of solutions was analyzed by high-performance liquid chromatography (HPLC). Results: The physical properties demonstrated that MC-SDP varies from dented to smoother surfaces as a function of sucrose. Furthermore, melting transitions of curcumin in the form of MC-SDP were broadened in all sample mixtures, as observed in the DTA thermogram. The XRD spectra showed that the sharp and very intense peaks of single curcumin crystalline structure no longer existed in all MC-SDP forms, indicating that the mixtures were amorphous. Moreover, a further dissolution study of MC-SDP showed a significant increase of drug dissolved with the presence of sucrose, where >80% of curcumin from MC-SDP was dissolved within 30 min. Conclusion: The study demonstrated the manufacture of micellar spray-dried powder that would contribute to the development of oral delivery of curcumin.

show abstract

Section: Differential Thermal Analysismentioning

confidence: 91%

<p>Characterization and Dissolution Study of Micellar Curcumin-Spray Dried Powder for Oral Delivery</p>

Wijiani¹,

Isadiartuti²,

Rijal³

et al. 2020

IJN

View full text Add to dashboard Cite

show abstract

“…In the goal of treating skin cancer, curcumin is delivered as self-assembled capsules with carboxymethyl cellulose and casein nanogels and fabricated with folic acid and casein by layer-by-layer (LbL) technique. The results showed better cellular uptake, cytotoxicity and apoptosis on melanoma cells (MEL-39) (Priya et al, 2020).…”

Section: Nanospheres and Microcapsulesmentioning

confidence: 95%

Nanocurcumin: A Promising Candidate for Therapeutic Applications

2020

View full text Add to dashboard Cite

“…The non-melanoma skin cancer represented by basal cell carcinoma, and squamous cell carcinoma. The skin cancer eruption leads to deformation of skin cells and may result in systemic migration and metastases if not diagnosed promptly [ 2 ]. The pathogenesis of skin cancer is multi-factorial, but the prevalent risk factor is long exposure to carcinogenic and inflammatory agent.…”

Section: Introductionmentioning

confidence: 99%

Plumbagin-Loaded Glycerosome Gel as Topical Delivery System for Skin Cancer Therapy

et al. 2021

View full text Add to dashboard Cite

Plumbagin (PLM) is a phytochemical which has shown cytotoxicity against of cancer cells both in vitro and in vivo. However, the clinical application of PLM has been hindered due to poor aqueous solubility and low bioavailability. The aim of the present study was to develop, optimize and evaluate PLM-loaded glycerosome (GM) gel and compare with conventional liposome (CL) for therapeutic efficacy against skin cancer. The GM formulations were optimized by employing design expert software by 3-level 3-factor design. The prepared GMs were characterized in vitro for vesicle size, size distribution, zeta potential, vesicle deformability, drug release, skin permeation, retention, texture, antioxidant and cytotoxicity activities. The optimized formulation showed a vesicle size of 119.20 ± 15.67 nm with a polydispersity index (PDI) of 0.145 ± 0.02, the zeta potential of −27 ± 5.12 mV and entrapment efficiency of 76.42 ± 9.98%. The optimized PLM-loaded GM formulation was transformed into a pre-formed gel which was prepared using Carbopol 934 polymer. The drug diffusion fluxes of CL gel and GM-loaded gel were 23.31 ±6.0 and 79.43 ± 12.43 µg/ cm2/h, respectively. The result of texture analysis revealed the adequate hardness, cohesiveness, consistency, and viscosity of the developed GM-loaded gel compared to CL gel. The confocal images showed that glycerosomal gel has deeper skin layer penetration as compared to the control solution. GM-loaded gel treated rat skin showed significantly (p < 0.05) higher drug accumulation in the dermis, higher cytotoxicity and higher antioxidant activity as compared to CL gel and PLM suspension. Thus, findings revealed that novel GM-loaded gel could be potential carriers for therapeutic intervention in skin cancer.

show abstract

Curcumin-loaded layer-by-layer folic acid and casein coated carboxymethyl cellulose/casein nanogels for treatment of skin cancer

Cited by 77 publications

References 46 publications

<p>Characterization and Dissolution Study of Micellar Curcumin-Spray Dried Powder for Oral Delivery</p>

<p>Characterization and Dissolution Study of Micellar Curcumin-Spray Dried Powder for Oral Delivery</p>

Nanocurcumin: A Promising Candidate for Therapeutic Applications

Plumbagin-Loaded Glycerosome Gel as Topical Delivery System for Skin Cancer Therapy

Contact Info

Product

Resources

About