Curcumin loaded ethosomes for transdermal application: Formulation, optimization, in-vitro and in-vivo study

Pathan, Inayat Bashir; Jaware, Bhaktraj P.; Shelke, Santosh; Ambekar, Wahid

doi:10.1016/j.jddst.2017.11.005

Cited by 77 publications

(33 citation statements)

References 41 publications

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“…The temperature in the bulk of the solution is maintained by circulating thermos stated water through a water jacket that surrounds the receptor compartment. The drug content is analyzed using suitable UV method, at 282 nm 6 .…”

Section: Preparation Of Duloxetine Ethosomal Based Transdermal Filmsmentioning

confidence: 99%

“…The receptor compartment was filled with phosphate buffer pH 7.4, kept at constant temperature of 37 ± 5 ºC and stirred using magnetic stirrer. At appropriate intervals (1,2,3,4,5,6,7,8 to 12 h), 1 ml of sample was withdrawn from receptor medium and immediately equal volume of fresh receptor solution was added to maintain sink condition of receptor medium. Periodically samples were collected and analyzed by UV spectrophotometer (Shimadzu-1800, Japan) at 282 nm using phosphate buffer (pH 6.8) as blank.…”

Section: Preparation Of Duloxetine Ethosomal Based Transdermal Filmsmentioning

confidence: 99%

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2020

IJPSR

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The present investigation deals with the development of duloxetine ethosome then loading into the transdermal patch to impart lower drug side effect, enhanced bioavailability, avoiding first-pass metabolism. 3 2 factorial design was applied to optimize the formulation. Ethanol (X1) and Phospholipid (X2) were taken as independent variable, Responses are vesicle size (Y2), entrapment efficiency (Y1). Optimum desirability was identified and, an optimized formulation was prepared, characterized and loaded into transdermal patch. The transdermal patch was evaluated for drug content, thickness, folding endurance. Ex-vivo permeation study for the prepared patch was conducted and, the permeation parameters and drug permeation mechanism were identified. The percent of alcohol was significantly affecting all the studied responses while the other factors and their interaction effects were varied in their effects on each response. The optimized ethosomes formulation showed observed values for Y2, Y1 of 161 nm and 98.79% respectively. Ex-vivo permeation of films loaded with optimized ethosomal formulation was superior to that of the corresponding pure drug transdermal Patches. INTRODUCTION: Flexible vesicular carriers are one of the approaches to enhance skin permeability of essential drugs, through the stratum corneum barrier. Liposomes, transfersomes, and ethosomes are three common types of these flexible particles although niosomes, non-ionic surfactant based vesicles, possess similar properties and uses 1. Conventional liposomes are the least among them in their transdermal application since they are confined to the upper layer of the skin stratum corneum and therefore, are topical delivery. Ethosomes are lipid-based vesicular particles containing ethanol in a relatively high concentration and water.

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Section: Preparation Of Duloxetine Ethosomal Based Transdermal Filmsmentioning

confidence: 99%

Section: Preparation Of Duloxetine Ethosomal Based Transdermal Filmsmentioning

confidence: 99%

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2020

IJPSR

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“…Ethosomesare non-invasive lipid vesicular carrier system in which it composed of phospholipid increased the concentration of alcohol (mostly ethanol) and water [57]. High concentration of alcohol makes this system more unique.…”

Section: Ethosomesmentioning

confidence: 99%

Novel Nanocarriers for Ethnopharmacological Formulations

Sivapriya¹,

Ponnarmadha²,

Nazeer³

et al. 2018

Int J App Pharm

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A numerous novel drug delivery system has been emerged by combining herbal medicine with nanotechnology to administer drugs encompassing the enhancement of compatibility and efficacy. The herbal phytoconstituents are compatible compared to the chemical active pharmaceutical ingredients (APIs). But the therapeutic consequence of the phytoconstituent is limited due to poor aqueous solubility. Therefore, the demand to develop a system which improves the solubility of the phytomedicine is mounting rapidly. Nanotechnology plays a vital role in increasing the solubility, enhancing the bioavailability and improving the drug specificity of bioactive constituents. Nanosystems such as liposomes, nanoparticles, phytosomes, ethosomes, nanoemulsions and solid lipid nanoparticles are used to deliver the bioactive constituent at an adequate dose to the site of action and during the entire treatment period. The current review discusses the various novel drug delivery systems which have been developed to attain better therapeutic response of the herbal drug.

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“…Ethosomes are composed of three main components: cholesterol, phospholipid, and ethanol. The concentration of these three components can influence several properties of ethosomes, including entrapment efficiency, size, and zeta potential [4].…”

Section: Introductionmentioning

confidence: 99%

“…Central composite design-response surface methodology (CCD-RSM) is considered as the preferred method for further optimization of the preparation using nonlinear model to achieve the most fitness with experimental data. RSM has shown higher certitude compared with many other methods, such as uniform design and orthogonal design [4]. Utilizing a critical aspect, the design of experiments (DOE), RSM has been broadly used for the developing, optimizing and validation of formulations.…”

Section: Introductionmentioning

confidence: 99%

Thymoquinone-loaded ethosome with breast cancer potential: optimization, in vitro and biological assessment

Nasri

Ebrahimi-Hosseinzadeh

Rahaie

et al. 2020

J Nanostruct Chem

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Ethosomes are most commonly used vesicular delivery system compared to other lipidic vesicles due to its ethanolic content. Thymoquinone (TQ), the main biologically active complex of Black Cumin seed, has established anticancer activities in several tumors. In this work, the preparation of ethosome for TQ encapsulation by response surface method (RSM) was developed. Central composite design (CCD) was used to optimize three effective parameters involved in ethosome structure including phospholipid, cholesterol and ethanol concentration and the combined effects of them, as well. The obtained optimum values for the variables were phospholipid 5% (W/W), ethanol 45% (V/V) and cholesterol 1.5% (W/W) which were validated by experimental assay. The ethosomal formulation was more characterized for vesicle shape, size, zeta potential and entrapment efficiency percentage. The result showed an efficiency of 99% for drug entrapment with average vesicle size and zeta potential of 20 ± 1 nm and − 63 ± 2 mv, respectively. A quadratic model with a high adequacy (R 2) for size and zeta potential of 0.9319 and 0.9338, respectively, was resulted from RSM and experimental assay. Thymoquinone (TQ) encapsulated in optimized ethosome. Also, cellular toxicity and release test was done. The toxicity and release curves were obtained and the cytotoxic activity of the ethosomic TQ against MCF-7 cell lines was greater than free TQ. IC50 values of free TQ, ethosomic TQ, were found to be 1.10 µg/ml, 0.95 µg/ml, respectively. The generated model suggests a new approach to prediction and experimental lipidic carriers.

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Curcumin loaded ethosomes for transdermal application: Formulation, optimization, in-vitro and in-vivo study

Cited by 77 publications

References 41 publications

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Novel Nanocarriers for Ethnopharmacological Formulations

Thymoquinone-loaded ethosome with breast cancer potential: optimization, in vitro and biological assessment

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