Curcumin-loaded chitosan-alginate-STPP nanoparticles ameliorate memory deficits and reduce glial activation in pentylenetetrazol-induced kindling model of epilepsy

Hashemian, Mona; Anissian, Diana; Ghasemi-Kasman, Maryam; Akbari, Atefeh; Khalili-Fomeshi, Mohsen; Ghasemi, Shahram; Ahmadi, Fatemeh; Moghadamnia, Ali Akbar; Ebrahimpour, Anahita

doi:10.1016/j.pnpbp.2017.07.025

Cited by 71 publications

(50 citation statements)

References 35 publications

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“…Based on these results, it has been postulated the neuroprotective effects of curcuminloaded nanoparticles might be a result of downregulation of TNF-α and subsequent upregulation of klotho and EPO. 75 Hashemian et al 76 has reported that encapsulation of curcumin onto chitosan-alginate-sodium tripolyphosphate nanoparticles (CS-ALG-STPP NPs) showed anti-epileptogenic effect by decreasing seizures stage and duration of GTCS. It has been also shown that curcumin-loaded NPs could attenuate memory deficits, glial activation and cell loss following PTZ adminstration.…”

Section: Application Of Nano-curcumin In Epilepsymentioning

confidence: 99%

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<p>Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders</p>

Yavarpour-Bali¹,

Ghasemi-Kasman²,

Pirzadeh³

2019

IJN

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205

100

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Curcumin as a hydrophobic polyphenol is extracted from the rhizome of Curcuma longa. Curcumin is widely used as a dietary spice and a topical medication for the treatment of inflammatory disorders in Asia. This compound also possesses remarkable anti-inflammatory and neuroprotective effects with the ability to pass from the blood brain barrier. Based on several pharmacological activities of curcumin, it has been introduced as an ideal candidate for different neurological disorders. Despite the pleiotropic activities of curcumin, poor solubility, rapid clearance and low stability have limited its clinical application. In recent years, nano-based drug delivery system has effectively improved the aqueous solubility and bioavailability of curcumin. In this review article, the effects of curcumin nanoparticles and their possible mechanism/s of action has been elucidated in various central nervous system (CNS)-related diseases including Parkinson's disease, Huntington disease, Alzheimer's disease, Multiple sclerosis, epilepsy and Amyotrophic Lateral Sclerosis. Furthermore, recent evidences about administration of nano-curcumin in the clinical trial phase have been described in the present review article.

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Section: Application Of Nano-curcumin In Epilepsymentioning

confidence: 99%

“…According to the results of this study, it has been suggested that curcumin-loaded CS-ALG-STTP NPs might be considered as an effective therapeutic approach in treatment of epileptic patients. 76…”

Section: Application Of Nano-curcumin In Epilepsymentioning

confidence: 99%

<p>Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders</p>

Yavarpour-Bali¹,

Ghasemi-Kasman²,

Pirzadeh³

2019

IJN

Self Cite

205

100

View full text Add to dashboard Cite

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“…When tested in PTZ kindled male NMRI mice, these nanoparticles at much lower dose of curcumin (12.5-25 mg/kg) were found to be effective in reducing the seizure stage and duration. The same doses of curcumin were found ineffective in this animal model (Hashemian et al, 2017). Additionally, the authors reported that lower doses of 12.5 and 25 mg/kg are effective in ameliorating both microglia and astrocytes activation in the hippocampus region of the brain (Hashemian et al, 2017).…”

Section: Bioavailability Issue With Curcuminmentioning

confidence: 91%

“…The same doses of curcumin were found ineffective in this animal model (Hashemian et al, 2017). Additionally, the authors reported that lower doses of 12.5 and 25 mg/kg are effective in ameliorating both microglia and astrocytes activation in the hippocampus region of the brain (Hashemian et al, 2017). have prepared nanoformulation of curcumin with the help of PLGA (poly(lactic-co-glycolic acid)) using high-pressure emulsification-solvent evaporation method.…”

Section: Bioavailability Issue With Curcuminmentioning

confidence: 99%

Curcumin in epilepsy disorders

Dhir

2018

Phytotherapy Research

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Curcumin, a principal curcuminoid present in turmeric, has an antioxidant, anti-inflammatory and neuroprotective properties. Preclinical studies have indicated its beneficial effect for the treatment of epilepsy disorders. The molecule has an anti-seizure potential in preclinical studies, including chemical and electrical models of acute and chronic epilepsy. Curcumin also possesses an anti-epileptogenic activity as it reduces spontaneous recurrent seizures severity in a kainate model of temporal lobe epilepsy. The antioxidant and anti-inflammatory nature of curcumin might be responsible for its observed anti-seizure effects; nevertheless, the exact mechanism is not yet clear. The poor availability of curcumin to the brain limits its use in clinics. The application of nanoliposome and liposome technologies has been tested to enhance its brain availability and penetrability. Unfortunately, there are no randomized, double-blinded controlled clinical trials validating the use of curcumin in epilepsy. The present article analyzes different preclinical evidence illustrating the effect of curcumin in seizure models. The review encourages carrying out clinical trials in this important area of research. In conclusion, curcumin might be beneficial in patients with epilepsy disorders, if its bioavailability issues are resolved.

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“…Curcumin has been extensively studied, and recently its promising therapeutic effect on epilepsy was evidenced 10 – 12 . This phytochemical did not prevent the occurrence of seizures, but weakened their severity and also showed a protective effect against cognitive deficits in a temporal lobe epilepsy model induced by status epilepticus in rats 10 .…”

Section: Introductionmentioning

confidence: 99%

Micronization potentiates curcumin’s anti-seizure effect and brings an important advance in epilepsy treatment

Bertoncello

Aguiar

Oliveira

et al. 2018

Sci Rep

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Epilepsy is one of the most common neurological diseases, and current antiepileptic drugs fail to suppress seizure occurrence in around one third of epileptic patients. Curcumin is a phytochemical with promising effects on epilepsy treatment. However, its application has been hindered by its low bioavailability. In order to improve curcumin’s anti-seizure properties, increasing its bioavailability, here we proposed to micronize the compound through supercritical carbon dioxide processing, a suitable green chemistry technique to prepare and modify material properties. Here we investigated the anti-seizure potential of the classical antiepileptic drug valproate, curcumin in its natural state, and micronized curcumin in a PTZ-induced seizure model in zebrafish (Danio rerio). Concerning seizure development, valproate, curcumin and micronized curcumin showed protective effects, slowing seizure development both in larvae and adult animals. Nevertheless, considering the occurrence of the tonic-clonic seizure stage, only valproate and micronized curcumin reduced it, both in larvae and adult zebrafish, unlike non-processed curcumin. Our obtained results are very promising, since micronized curcumin showed effects that are similar to a classic antiepileptic drug, reducing seizure occurrence and slowing seizure progression.

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Curcumin-loaded chitosan-alginate-STPP nanoparticles ameliorate memory deficits and reduce glial activation in pentylenetetrazol-induced kindling model of epilepsy

Cited by 71 publications

References 35 publications

<p>Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders</p>

<p>Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders</p>

Curcumin in epilepsy disorders

Micronization potentiates curcumin’s anti-seizure effect and brings an important advance in epilepsy treatment

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