Curcumin-Loaded Biodegradable Electrospun Fibers: Preparation, Characterization, and Differences in Fiber Morphology

Luz, Priscilla Paiva; Silva, Márcio Luís Andrade e; Hinestroza, Juan P.

doi:10.1080/1023666x.2013.816207

Cited by 7 publications

(5 citation statements)

References 30 publications

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“…The breaking strength increased slightly and the tensile elongation increased significantly probably because the addition of small molecules can facilitate molecular chain slip in the fiber; and the moisture regain decreased probably due to the hydrophobic character of the drugs. Hence, compared to the blank PAN, blended spun fibers containing curcumin and vitamin E acetate can enhance the mechanical properties of the composite materials as also observed in previous studies[17,18,23]. By contrast, the standard deviations (SD)showed low values of 0.13, 0.17, 0.14, 0.16 for breaking strength and 1.37, 2.05, 2.26, 2.53 for tensile elongation reflecting relatively good accuracy and stability during manufacturing process.…”

supporting

confidence: 74%

“…In the field of textile dyeing, curcumin it has been widely studied since it is a natural pigment, [9,15] and it has high color stability and good fastness due to its structure [16]. One concern, however, is that the mechanical properties of the fibers after drug loading will decrease, but on the contrary, studies have indicated that the addition of curcumin to the fiber is beneficial [17,18]. Vitamin E (-tocopherol; Vit.…”

Section: Introductionmentioning

confidence: 99%

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A novel multifunctional biomedical material based on polyacrylonitrile: Preparation and characterization

Bremner

et al. 2016

Materials Science and Engineering: C

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Wet spun microfibers have great potential in the design of multifunctional controlled release materials. Curcumin (Cur) and vitamin E acetate (Vit. E Ac) were used as a model drug system to evaluate the potential application of the drug-loaded microfiber system for enhanced delivery. The drugs and polyacrylonitrile (PAN) were blended together and spun to produce the target drug-loaded microfiber using an improved wet-spinning method and then the microfibers were successfully woven into fabrics. Morphological, mechanical properties, thermal behavior, drug release performance characteristics, and cytocompatibility were determined. The drug-loaded microfiber had a lobed "kidney" shape with a height of 50-100 μm and width of 100-200 μm. The addition of Cur and Vit. E Ac had a great influence on the surface and cross section structure of the microfiber, leading to a rough surface having microvoids. X-ray diffraction and Fourier transform infrared spectroscopy indicated that the drugs were successfully encapsulated and dispersed evenly in the microfilament fiber. After drug loading, the mechanical performance of the microfilament changed, with the breaking strength improved slightly, but the tensile elongation increased significantly. Thermogravimetric results showed that the drug load had no apparent adverse effect on the thermal properties of the microfibers. However, drug release from the fiber, as determined through in-vitro experiments, is relatively low and this property is maintained over time. Furthermore, in-vitro cytocompatibility testing showed that no cytotoxicity on the L929 cells was found up to 5% and 10% respectively of the theoretical drug loading content (TDLC) of curcumin and vitamin E acetate. This study provides reference data to aid the development of multifunctional textiles and to explore their use in the biomedical material field.

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confidence: 74%

Section: Introductionmentioning

confidence: 99%

A novel multifunctional biomedical material based on polyacrylonitrile: Preparation and characterization

Bremner

et al. 2016

Materials Science and Engineering: C

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“…Priscilla P. Luz with collaborators 43 described curcumin-loaded poly(lactic acid) (PLA) and poly(lactic- co -glycolic acid) (PLGA) electrospun nanofibers with an average diameter equal to 3600 nm and 123.6 nm, respectively. The first one could be characterized as nonrigid and with an irregular surface, while the second one was porous and had rigidity.…”

Section: Polymers Used For Curcumin-loaded Fiber Formationmentioning

confidence: 99%

Electrospun curcumin-loaded polymer nanofibers: solution recipes, process parameters, properties, and biological activities

et al. 2022

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“…Interestingly, the entrapment efficiency was increased with an increase in gelatin content in the fibers which may be ascribed to partial interactions between curcumin and gelatin (Nguyen et al 2019). Luz stated that the percentage of curcumin per milligram of fiber was 4.0 ± 0.2% for PLA/ curcumin fibers and 1.8 ± 0.1% for PLGA/curcumin fibers (Luz et al 2013).…”

Section: Entrapment Efficiencymentioning

confidence: 99%

Curcumin-loaded, alginate–gelatin composite fibers for wound healing applications

et al. 2020

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The wound healing process is characterized by varied biological and molecular cascades including inflammation, tissue proliferation, and remodeling phase. To augment and maintain these cascades, an all-natural matrix system is proposed. Biocompatible biopolymers, sodium alginate and gelatin, were employed to prepare microfibers via extrusion-gelation into a physical crosslinking solution. Curcumin, an anti-inflammatory, anti-oxidant and wound healing agent, was loaded into the fibers as a natural bioactive compound. Curcumin-loaded composite microfibers and blank microfibers were fabricated using biopolymers such as sodium alginate and gelatin. The formulation batches were coded as A1G9-A10G0 according to the varied concentrations of sodium alginate and gelatin. The molecular transitions within the composite microfibers were characterized using FTIR and were further corroborated using molecular mechanics analysis. In mechanical properties tensile strength and elongation-at-break (extensibility) were ranging between 1.08 ± 0.01 to 3.53 ± 0.41 N/mm 2 and 3.89 ± 0.18 to 0.61 ± 0.03%. The morphological analysis confirmed the formation and fabrication of the microfibers. In addition, physical evaluation including matrix degradation and entrapment efficiency was performed to give a comparative account of various formulations. The water uptake capacity of the blank and curcumin-loaded composite fibers was found to be in the range of 30.77 ± 2.17 to 100.00 ± 5.99 and 22.34 ± 1.11 to 56.34 ± 4.68, respectively. Composite microfibers presented a cumulative release of 85% in 72 h, confirming the prolonged release potential of the composite fibers. The drug release followed an anomalous (non-Fickian) release behavior asserting the role of degradation and diffusion. In an in vivo full-thickness cutaneous wound model, the composite microfibers provided higher degree of contraction 96.89 ± 3.76% as compared to the marketed formulation (Vicco turmeric cream). In conclusion, this all-natural, alginate-gelatin-curcumin composite has the potential to be explored as a cost-effective wound healing platform.

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Curcumin-Loaded Biodegradable Electrospun Fibers: Preparation, Characterization, and Differences in Fiber Morphology

Cited by 7 publications

References 30 publications

A novel multifunctional biomedical material based on polyacrylonitrile: Preparation and characterization

A novel multifunctional biomedical material based on polyacrylonitrile: Preparation and characterization

Electrospun curcumin-loaded polymer nanofibers: solution recipes, process parameters, properties, and biological activities

Curcumin-loaded, alginate–gelatin composite fibers for wound healing applications

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