Curcumin-lipoic acid conjugate as a promising anticancer agent on the surface of gold‑iron oxide nanocomposites: A pH-sensitive targeted drug delivery system for brain cancer theranostics

Ghorbani, Mazaher; Bigdeli, Bahareh; Jalili‐Baleh, Leili; Baharifar, Hadi; Akrami, Mohammad; Dehghani, Sadegh; Goliaei, Bahram; Amani, Amir; Lotfabadi, Alireza; Rashedi, Hamid; Haririan, Ismaeil; Alam, Nader Riahi; Hamedani, M Pirali

doi:10.1016/j.ejps.2017.12.008

Cited by 75 publications

(41 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Different strategies can be used to engineer the surface of the nanoparticles, including the use of biomarkers, ligands, proteins and genes. Moreover, smart nanocarriers can take advantage of the specific microenvironment using (internal or external) stimuli-responsive triggers [237].…”

Section: Combining Therapeutic Diagnostic and Stimuli-responsive Funmentioning

confidence: 99%

Curcumin’s Nanomedicine Formulations for Therapeutic Application in Neurological Diseases

Salehi

Calina

Docea

et al. 2020

JCM

134

View full text Add to dashboard Cite

The brain is the body’s control center, so when a disease affects it, the outcomes are devastating. Alzheimer’s and Parkinson’s disease, and multiple sclerosis are brain diseases that cause a large number of human deaths worldwide. Curcumin has demonstrated beneficial effects on brain health through several mechanisms such as antioxidant, amyloid β-binding, anti-inflammatory, tau inhibition, metal chelation, neurogenesis activity, and synaptogenesis promotion. The therapeutic limitation of curcumin is its bioavailability, and to address this problem, new nanoformulations are being developed. The present review aims to summarize the general bioactivity of curcumin in neurological disorders, how functional molecules are extracted, and the different types of nanoformulations available.

show abstract

Section: Combining Therapeutic Diagnostic and Stimuli-responsive Funmentioning

confidence: 99%

Curcumin’s Nanomedicine Formulations for Therapeutic Application in Neurological Diseases

Salehi

Calina

Docea

et al. 2020

JCM

134

View full text Add to dashboard Cite

show abstract

“…Metallic NPs for brain delivery have been under investigation due to their serum stability and long half-life. Ghorbani et al (2018) reported the use of gold-iron nanocomposites encapsulated with curcumin-lipoic acid, a pH-sensitive delivery system for the brain. GSH is used as targeting ligand, leading to 2-fold increases in cellular uptake [110].…”

Section: Metallic Npsmentioning

confidence: 99%

“…Ghorbani et al (2018) reported the use of gold-iron nanocomposites encapsulated with curcumin-lipoic acid, a pH-sensitive delivery system for the brain. GSH is used as targeting ligand, leading to 2-fold increases in cellular uptake [110]. Nosrati et al (2019) reported the use for glutathione (GSH) decorated iron NPs (GSHIONPs) for brain drug delivery.…”

Section: Metallic Npsmentioning

confidence: 99%

Peptide based drug delivery systems to the brain

Islam

Leach

Smith³

et al. 2020

Nano Express

View full text Add to dashboard Cite

With estimated worldwide cost over $1 trillion just for dementia, diseases of the central nervous system pose a major problem to health and healthcare systems, with significant socio-economic implications for sufferers and society at large. In the last two decades, numerous strategies and technologies have been developed and adapted to achieve drug penetration into the brain, evolving alongside our understanding of the physiological barriers between the brain and surrounding tissues. The blood brain barrier (BBB) has been known as the major barrier for drug delivery to the brain. Both invasive and minimally-invasive approaches have been investigated extensively, with the minimallyinvasive approaches to drug delivery being more suitable. Peptide based brain targeting has been explored extensively in the last two decades. In this review paper, we focused on self-assembled peptides, shuttle peptides and nanoparticles drug delivery systems decorated/conjugated with peptides for brain penetration.Abbreviations

show abstract

“…The release profile of ORI from ORI-GPC1-NPs was determined in serum containing media according to a reported procedure with some modifications. 36 In brief, 1 mL of ORI-GPC1-NPs was added to 9 mL of 10% FBS containing media at pH 7.4, pH 5.5, and pH 5.5+ hyaluronidase (60 U/mL). ORI-loaded GPC1-ORI-NPs were isolated by centrifugation at 8,000 rpm for 20 minutes and the supernatants were collected.…”

Section: In Vitro Drug Releasementioning

confidence: 99%

Oridonin-loaded and GPC1-targeted gold nanoparticles for multimodal imaging and therapy in pancreatic cancer

Qiu¹,

Chen²,

Xiao³

et al. 2018

IJN

View full text Add to dashboard Cite

PurposeEarly diagnosis and therapy are critical to improve the prognosis of patients with pancreatic cancer. However, conventional imaging does not significantly increase the capability to detect early stage disease. In this study, we developed a multifunctional theranostic nanoplatform for accurate diagnosis and effective treatment of pancreatic cancer.MethodsWe developed a theranostic nanoparticle (NP) based on gold nanocages (AuNCs) modified with hyaluronic acid (HA) and conjugated with anti-Glypican-1 (anti-GPC1) antibody, oridonin (ORI), gadolinium (Gd), and Cy7 dye. We assessed the characteristics of GPC1-Gd-ORI@HAuNCs-Cy7 NPs (ORI-GPC1-NPs) including morphology, hydrodynamic size, stability, and surface chemicals. We measured the drug loading and release efficiency in vitro. Near-infrared fluorescence (NIRF)/magnetic resonance imaging (MRI) and therapeutic capabilities were tested in vitro and in vivo.ResultsORI-GPC1-NPs demonstrated long-time stability and fluorescent/MRI properties. Bio-transmission electron microscopy (bio-TEM) imaging showed that ORI-GPC1-NPs were endocytosed into PANC-1 and BXPC-3 (overexpression GPC1) but not in 293 T cells (GPC1- negative). Compared with ORI and ORI-NPs, ORI-GPC1-NPs significantly inhibited the viability and enhanced the apoptosis of pancreatic cancer cells in vitro. Moreover, blood tests suggested that ORI-GPC1-NPs showed negligible toxicity. In vivo studies showed that ORI-GPC1-NPs enabled multimodal imaging and targeted therapy in pancreatic tumor xenografted mice.ConclusionORI-GPC1-NP is a promising theranostic platform for the simultaneous diagnosis and effective treatment of pancreatic cancer.

show abstract

Curcumin-lipoic acid conjugate as a promising anticancer agent on the surface of gold‑iron oxide nanocomposites: A pH-sensitive targeted drug delivery system for brain cancer theranostics

Cited by 75 publications

References 55 publications

Curcumin’s Nanomedicine Formulations for Therapeutic Application in Neurological Diseases

Curcumin’s Nanomedicine Formulations for Therapeutic Application in Neurological Diseases

Peptide based drug delivery systems to the brain

Oridonin-loaded and GPC1-targeted gold nanoparticles for multimodal imaging and therapy in pancreatic cancer

Contact Info

Product

Resources

About