Curcumin-laden exosomes target ischemic brain tissue and alleviate cerebral ischemia-reperfusion injury by inhibiting ROS-mediated mitochondrial apoptosis

He, Ruyi; Jiang, Yibing; Shi, Yijie; Liang, Jia; Zhao, Liang

doi:10.1016/j.msec.2020.111314

Cited by 94 publications

(55 citation statements)

References 51 publications

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“… 29 Furthermore, this polyphenol has shown outstanding in vitro and in vivo results in biomedical studies involving different diseases, such as diabetes. 29 Recent investigations have demonstrated the effectiveness of CUR in diminishing the oxidative damage associated with aging and also to treat brain ischemia 30 and Alzheimer’s disease. 31 It has been also highlighted the ability of CUR to improve the proliferation of stem cells, 32 which is crucial for the process of tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

Curcuminoid-Tailored Interfacial Free Energy of Hydrophobic Fibers for Enhanced Biological Properties

Deus

França

Forero

et al. 2021

ACS Appl. Mater. Interfaces

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The ability of mimicking the extracellular matrix architecture has gained electrospun scaffolds a prominent space into the tissue engineering field. The high surface-to-volume aspect ratio of nanofibers increases their bioactivity while enhancing the bonding strength with the host tissue. Over the years, numerous polyesters, such as poly(lactic acid) (PLA), have been consolidated as excellent matrices for biomedical applications. However, this class of polymers usually has a high hydrophobic character, which limits cell attachment and proliferation, and therefore decreases biological interactions. In this way, functionalization of polyester-based materials is often performed in order to modify their interfacial free energy and achieve more hydrophilic surfaces. Herein, we report the preparation, characterization, and in vitro assessment of electrospun PLA fibers with low contents (0.1 wt %) of different curcuminoids featuring π-conjugated systems, and a central β-diketone unit, including curcumin itself. We evaluated the potential of these materials for photochemical and biomedical purposes. For this, we investigated their optical properties, water contact angle, and surface features while assessing their in vitro behavior using SH-SY5Y cells. Our results demonstrate the successful generation of homogeneous and defect-free fluorescent fibers, which are noncytotoxic, exhibit enhanced hydrophilicity, and as such greater cell adhesion and proliferation toward neuroblastoma cells. The unexpected tailoring of the scaffolds’ interfacial free energy has been associated with the strong interactions between the PLA hydrophobic sites and the nonpolar groups from curcuminoids, which indicate its role for releasing hydrophilic sites from both parts. This investigation reveals a straightforward approach to produce photoluminescent 3D-scaffolds with enhanced biological properties by using a polymer that is essentially hydrophobic combined with the low contents of photoactive and multifunctional curcuminoids

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Section: Introductionmentioning

confidence: 99%

Curcuminoid-Tailored Interfacial Free Energy of Hydrophobic Fibers for Enhanced Biological Properties

Deus

França

Forero

et al. 2021

ACS Appl. Mater. Interfaces

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show abstract

“…A variety of antioxidants have been experimentally tested in treating IRI. Moreover, it has been recently reported that melatonin [ 47 ], curcumin [ 48 ], stem cell [ 49 ], and nanoparticles [ 50 ] are all effective methods for treating or preventing IRI in multiple organs. As more and more studies are focused on SS-31 in IRI, it has become a potential treatment for IRI [ 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

SS‐31 Protects Liver from Ischemia‐Reperfusion Injury via Modulating Macrophage Polarization

Shang

Ren

Wang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Ischemia-reperfusion injury (IRI) is a common complication in liver surgeries. It is a focus to discover effective treatments to reduce ischemia-reperfusion injury. Previous studies show that oxidative stress and inflammation response contribute to the liver damage during IRI. SS-31 is an innovated mitochondrial-targeted antioxidant peptide shown to scavenge reactive oxygen species and decrease oxidative stress, but the protective effects of SS-31 against hepatic IRI are not well understood. The aim of our study is to investigate whether SS-31 could protect the liver from damages induced by IRI and understand the protective mechanism. The results showed that SS-31 treatment can significantly attenuate liver injury during IRI, proved by HE staining, serum ALT/AST, and TUNEL staining which can assess the degree of liver damage. Meanwhile, we find that oxidative stress and inflammation were significantly suppressed after SS-31 administration. Furthermore, the mechanism revealed that SS-31 can directly decrease ROS production and regulate STAT1/STAT3 signaling in macrophages, thus inhibiting macrophage M1 polarization. The proinflammation cytokines are then significantly reduced, which suppress inflammation response in the liver. Taken together, our study discovered that SS-31 can regulate macrophage polarization through ROS scavenging and STAT1/STAT3 signaling to ameliorate liver injury; the protective effects against hepatic IRI suggest that SS-31 may be an appropriate treatment for liver IRI in the clinic.

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“…It involves the application of centrifugal force to an exosome-containing solution (cell culture media or biological fluids) [51], for example, isolation of astrocyte-derived exosomes to carry microRNA-17-5p to protect neonatal rats from hypoxic ischemic brain damage by inhibiting Bcl-2 and nineteen kilodalton-interacting proteins 2 (BNIP 2) expression [52]. Another study also reports the use of ultracentrifugation technique for isolation of exosome to entrap curcumin for treatment of ischemic brain [53].…”

Section: Isolation and Purification Methods For Exosome In Brain Diseasesmentioning

confidence: 99%

Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases

Shetgaonkar

Marques

DCruz³

et al. 2021

Drug Deliv. and Transl. Res.

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Exosomes are extracellular vesicles with the diameter ranging from 50 to 100 nm and are found in different body fluids such as blood, cerebrospinal fluid (CSF), urine and saliva. Like in case of various diseases, based on the parent cells, the content of exosomes (protein, mRNA, miRNA, DNA, lipids and metabolites) varies and thus can be utilized as potential biomarker for diagnosis and prognosis of the brain diseases. Furthermore, utilizing the natural potential exosomes to cross the blood–brain barrier and by specifically decorating it with the ligand as per the desired brain sites therapeutics can be delivered to brain parenchyma. This review article conveys the importance of exosomes and their use in the treatment and diagnosis of brain/central nervous system diseases. Graphical abstract

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Curcumin-laden exosomes target ischemic brain tissue and alleviate cerebral ischemia-reperfusion injury by inhibiting ROS-mediated mitochondrial apoptosis

Cited by 94 publications

References 51 publications

Curcuminoid-Tailored Interfacial Free Energy of Hydrophobic Fibers for Enhanced Biological Properties

Curcuminoid-Tailored Interfacial Free Energy of Hydrophobic Fibers for Enhanced Biological Properties

SS‐31 Protects Liver from Ischemia‐Reperfusion Injury via Modulating Macrophage Polarization

Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases

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