Curcumin Inhibits the Proliferation and Invasiveness of <scp>MHCC</scp>97‐<scp>H</scp> Cells via <scp>p</scp>38 Signaling Pathway

Zhang, Kai; Rui, Xiaojiang; Yan, Xin

doi:10.1002/ddr.21210

Cited by 11 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, we found curcumin regulates CSCs induced by phthalates. Previous studies have shown that high concentrations of curcumin inhibit cell growth (20–108 μM), − induce apoptosis (10–40 μM), , and cause cell cycle arrest (25–50 μM) of HCC. The present study showed that a low concentration of curcumin (5 μM) significantly blocked DEHP-induced migration, invasion, and CSC maintenance of human HCC cells.…”

Section: Discussionmentioning

confidence: 99%

Curcumin Suppresses Phthalate-Induced Metastasis and the Proportion of Cancer Stem Cell (CSC)-like Cells via the Inhibition of AhR/ERK/SK1 Signaling in Hepatocellular Carcinoma

Tsai

Hsieh

Lee

et al. 2015

J. Agric. Food Chem.

View full text Add to dashboard Cite

Recent evidence indicating that phthalates promote cancer development, including cell proliferation, migration, and invasion, has raised public health concerns. Here, we show that bis(2-ethylhexyl) phthalate promotes the migration, invasion, and epithelial-mesenchymal transition of hepatocellular carcinoma cells. In addition, bis(2-ethylhexyl) phthalate increased the proportion of cancer stem cell (CSC)-like cells and stemness maintenance in vitro as well as tumor growth and metastasis in vivo. The various activities of curcumin, including anticancer, anti-inflammation, antioxidation, and immunomodulation, have been investigated extensively. Curcumin suppressed phthalate-induced cell migration, invasion, and epithelial-mesenchymal transition, decreased the proportion of CSC-like cells in hepatocellular carcinoma cell lines in vitro, and inhibited tumor growth and metastasis in vivo. We also reveal that curcumin suppressed phthalate-induced migration, invasion, and CSC-like cell maintenance through inhibition of the aryl hydrocarbon receptor/ERK/SK1/S1P3 signaling pathway. Our results suggest that curcumin may be a potential antidote for phthalate-induced cancer progression.

show abstract

Section: Discussionmentioning

confidence: 99%

Curcumin Suppresses Phthalate-Induced Metastasis and the Proportion of Cancer Stem Cell (CSC)-like Cells via the Inhibition of AhR/ERK/SK1 Signaling in Hepatocellular Carcinoma

Tsai

Hsieh

Lee

et al. 2015

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…Curcumin, also known as diferuloylmethane, is obtained from Curcuma longa , and is regarded as a potent anticancer drug in various types of tumor, including HCC ( 18 – 21 ). Previous studies have demonstrated that curcumin is able to effectively inhibit the proliferation of HCC cells in vitro and in vivo ( 22 – 25 ). In addition, curcumin significantly enhances the antitumor effects of certain traditional chemotherapeutic drugs and molecular-targeted drugs ( 26 – 32 ).…”

Section: Introductionmentioning

confidence: 99%

Curcumin enhances the antitumor effect of ABT-737 via activation of the ROS-ASK1-JNK pathway in hepatocellular carcinoma cells

Ren

You

Jia

et al. 2015

Molecular Medicine Reports

View full text Add to dashboard Cite

At present, the therapeutic treatment strategies for patients with hepatocellular carcinoma (HCC) remain unsatisfactory, and novel methods are urgently required to treat this disease. Members of the B cell lymphoma (Bcl)-2 family are anti-apoptotic proteins, which are commonly expressed at high levels in certain HCC tissues and positively correlate with the treatment resistance of patients with HCC. ABT-737, an inhibitor of Bcl-2 anti-apoptotic proteins, has been demonstrated to exhibit potent antitumor effects in several types of tumor, including HCC. However, treatment with ABT-737 alone also activates certain pro-survival signaling pathways, which attenuate the antitumor validity of ABT-737. Curcumin, which is obtained from Curcuma longa, is also an antitumor potentiator in multiple types of cancer. In the present study, the synergistic effect of curcumin and ABT-737 on HCC cells was investigated for the first time, to the best of our knowledge. It was found that curcumin markedly enhanced the antitumor effects of ABT-737 on HepG2 cells, which was partially dependent on the induction of apoptosis, according to western blot analysis and flow cytometric apoptosis analysis. In addition, the sustained activation of the ROS-ASK1-c-Jun N-terminal kinase pathway may be an important mediator of the synergistic effect of curcumin and ABT-737. Collectively, these results indicated that the combination of curcumin and ABT-737 can efficaciously induce the death of HCC cells, and may offer a potential treatment strategy for patients with HCC.

show abstract

“…Therefore, we infer that curcumin has demonstrated to be an effective agent against cancer cell migration and metastasis. Therefore, in our study, we conclude that curcumin has significantly reduced cell invasion [22][23][24].…”

Section: Discussionmentioning

confidence: 60%

Effects of Curcumin-Loaded Poly(Lactic-Co-Glycolic Acid) Nanoparticles in MDA-MB231 Human Breast Cancer Cells

Sharma

Hawthorne

Jha

et al. 2021

Nanomedicine (Lond.)

View full text Add to dashboard Cite

Aim: This study was aimed at evaluating the anticancer potential of curcumin-loaded poly(lactic-co-glycolic acid) (PLGA) based nanoparticles (NPs) in MDA-MB231 human breast cancer cells. Methods: Curcumin-loaded PLGA NPs were developed using a modified solvent evaporation technique. Physical characterization was performed on the formulated NPs. Furthermore, in vitro experiments were conducted to study the biological activity of the curcumin-loaded NPs. Results: Curcumin-loaded PLGA NPs demonstrated high encapsulation efficiency and sustained payload release. Moreover, the NPs exhibited a significant reduction in cell viability, cell migration and cell invasion in the MDA-MB231 cells. Conclusion: The study revealed that the formulated curcumin-loaded PLGA NPs possessed significant anti-metastatic properties. The findings showcased the possible potential of curcumin-loaded NPs in the management of debilitating conditions such as cancer. In addition, this study could form the basis for further research and advancements in this area.

show abstract

Curcumin Inhibits the Proliferation and Invasiveness of MHCC97‐H Cells via p38 Signaling Pathway

Cited by 11 publications

References 19 publications

Curcumin Suppresses Phthalate-Induced Metastasis and the Proportion of Cancer Stem Cell (CSC)-like Cells via the Inhibition of AhR/ERK/SK1 Signaling in Hepatocellular Carcinoma

Curcumin Suppresses Phthalate-Induced Metastasis and the Proportion of Cancer Stem Cell (CSC)-like Cells via the Inhibition of AhR/ERK/SK1 Signaling in Hepatocellular Carcinoma

Curcumin enhances the antitumor effect of ABT-737 via activation of the ROS-ASK1-JNK pathway in hepatocellular carcinoma cells

Effects of Curcumin-Loaded Poly(Lactic-Co-Glycolic Acid) Nanoparticles in MDA-MB231 Human Breast Cancer Cells

Contact Info

Product

Resources

About