Curcumin inhibits Th1 cytokine profile in CD4<sup>+</sup> T cells by suppressing interleukin‐12 production in macrophages

Kang, Bok Yun; Song, Young-A; Kim, K; Choe, Yong Kyung; Hwang, Seung Yong; Kim, T S

doi:10.1038/sj.bjp.0702803

Cited by 107 publications

(69 citation statements)

References 32 publications

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“…Earlier studies have shown that the inhibition of IL-12 production or IL-12 signaling was effective in preventing the clinical and pathological symptoms of EAE (30,31). In this study, we have confirmed the recent reports that curcumin inhibits LPSinduced production of IL-12 in macrophage cells in vitro (47,48). The inhibition of IL-12 production observed in this study in MBPimmune spleen cells in response to neural Ags suggests that the inhibition of IL-12 is a mechanism of regulation of EAE by curcumin.…”

Section: Discussionsupporting

confidence: 80%

“…Although the exact mechanisms involved in the antiinflammatory activity of curcumin is not fully defined, it prevents the activation of NF-B, AP-1, and c-Jun kinase (45,46). Recent studies have also shown that curcumin inhibits IL-12 production from macrophages and thereby prevents the differentiation of Th1 cells in vitro (47,48). However, no previous study has examined the use of curcumin in the treatment of MS or other Th1 cellmediated inflammatory diseases of the CNS.…”

Section: Ultiple Sclerosis (Ms)mentioning

confidence: 99%

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Curcumin Inhibits Experimental Allergic Encephalomyelitis by Blocking IL-12 Signaling Through Janus Kinase-STAT Pathway in T Lymphocytes

Natarajan

Bright

2002

The Journal of Immunology

260

169

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Experimental allergic encephalomyelitis (EAE) is a CD4+ Th1 cell-mediated inflammatory demyelinating autoimmune disease of the CNS that serves as an animal model for multiple sclerosis (MS). IL-12 is a proinflammatory cytokine that plays a crucial role in the induction of neural Ag-specific Th1 differentiation and pathogenesis of CNS demyelination in EAE and MS. Curcumin (1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is a naturally occurring polyphenolic phytochemical isolated from the rhizome of the medicinal plant Curcuma longa. It has profound anti-inflammatory activity and been traditionally used to treat inflammatory disorders. In this study we have examined the effect and mechanism of action of curcumin on the pathogenesis of CNS demyelination in EAE. In vivo treatment of SJL/J mice with curcumin significantly reduced the duration and clinical severity of active immunization and adoptive transfer EAE. Curcumin inhibited EAE in association with a decrease in IL-12 production from macrophage/microglial cells and differentiation of neural Ag-specific Th1 cells. In vitro treatment of activated T cells with curcumin inhibited IL-12-induced tyrosine phosphorylation of Janus kinase 2, tyrosine kinase 2, and STAT3 and STAT4 transcription factors. The inhibition of Janus kinase-STAT pathway by curcumin resulted in a decrease in IL-12-induced T cell proliferation and Th1 differentiation. These findings highlight the fact that curcumin inhibits EAE by blocking IL-12 signaling in T cells and suggest its use in the treatment of MS and other Th1 cell-mediated inflammatory diseases.

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Section: Discussionsupporting

confidence: 80%

Section: Ultiple Sclerosis (Ms)mentioning

confidence: 99%

Curcumin Inhibits Experimental Allergic Encephalomyelitis by Blocking IL-12 Signaling Through Janus Kinase-STAT Pathway in T Lymphocytes

Natarajan

Bright

2002

The Journal of Immunology

260

169

View full text Add to dashboard Cite

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“…Kang BY et al, demonstrated that curcumin significantly inhibits production of IL-12, reduces the induction of IFN-g, IL-4 in CD4+ T-cells by macrophages, leading to the inhibition of Th1 cytokine profile [23]. Chainani Wu N showed that curcumin inhibits several agents involved in inflammation including phospholipase, lipoxygenase, cyclooxygenase-2, leukotrienes, thromboxane, prostaglandins, nitric oxide, collagenase, elastase, hyaluronidase, monocyte chemoattractant protein-1, interferon-inducible protein, tumour necrosis factor alpha and interleukin-12 [24].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Efficacy of Curcumin as an Add-on therapy in Patients of Bronchial Asthma

Abidi

Gupta

Agarwal

et al. 2014

JCDR

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Background: Bronchial asthma being a chronic inflammatory disease of airways has numerous treatment options none of which have disease modifying properties. Curcumin, a yellow dietary pigment has varied pharmacological activities, prominent among which is an anti-inflammatory activity which may be crucial in bronchial asthma as has been proved by various in vitro and in vivo animal studies. Aims:To determine the efficacy and safety of curcumin as an 'add-on' therapy in patients of bronchial asthma. Settings and Design:This study was conducted on 77 patients of mild to moderate Bronchial asthma who had a documented positive bronchodilator reversibility test with ≥15% improvement in forced expiratory volume one second (FEV1). Materials and Methods:Seventy seven patients were recruited for the study and randomized into either of the two groups, but 17 patients were lost to follow up. Thus Group A -Receiving standard therapy for bronchial asthma for 30d (n=30) and Group B -Receiving standard therapy for bronchial asthma + Cap Curcumin 500mg BD daily for 30d (n=30). The predefined primary endpoints were clinical assessments of dyspnoea, wheezing, cough, chest tightness and nocturnal symptoms, change in the pre-bronchodilator FEV1 during the treatment and hematological improvement. The secondary end points were assessed by the change in the post-bronchodilator FEV1, C-reactive protein (CRP) concentration and incidence of adverse events. Statistical Analysis used:The data was analysed by SPSS 17.0 software using one-way ANOVA or Paired t-test.

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“…Moreover, inhibition of IL-2 production led to the inhibition of Th1 and enhancement of Th2 cytokine synthesis in CD4+ T cells [27].…”

Section: Discussionmentioning

confidence: 99%

Influence of Dietary Soy Phytoestrogens on Cytokine Production and Immunoglobulin in Ovariectomized Rats

2016

IJACEBS

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Abstract-This study was designed to examine the relationship between soy phytoestrogens supplementation in ovariectomized rats and pro-inflammatory cytokines Interleukin 1 alpha (IL-1α), Interleukin 2 (IL-2), Interleukin 4 (IL-4) and immunoglobulin. Twenty four female rats were ovariectomized then divided equally into 3 groups; control group, was fed on casein based diet, low soy phytoestrogens group was fed a diet contained 7% soy and high soy phytoestrogens group received a diet of 26% soy for 28 days. At the end of experiment, rats were weighed then blood samples were collected on EDTA for total leukocyte count (TLC). Serum samples were taken for interleukins assay, lysozyme activity and immunoglobulin. Animals were sacrificed and thymus and spleen were weighed. The body weight gain was significantly declined in ovariectomized rats fed high soy diet at the first 3 weeks of the experiment. Rats fed high soy diet showed significant reduction in thymic weight compared to control ones. IL-1α and IL-2 were significantly suppressed in rats fed high soy diet compared to control rats. However, IL-4 was significantly stimulated in rats fed high soy diet compared to control rats. Both IgM and IgG levels were significantly increased in rats fed high soy diet compared to control rats. There was a significant decrease in lysozyme activity in rats fed high soy diet compared to rats fed low soy diet. TLC was significantly increased in rats fed high and low soy diets. In conclusion, soy supplementation altered selected immunological parameters of ovariectomized female rats.

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Curcumin inhibits Th1 cytokine profile in CD4⁺ T cells by suppressing interleukin‐12 production in macrophages

Cited by 107 publications

References 32 publications

Curcumin Inhibits Experimental Allergic Encephalomyelitis by Blocking IL-12 Signaling Through Janus Kinase-STAT Pathway in T Lymphocytes

Curcumin Inhibits Experimental Allergic Encephalomyelitis by Blocking IL-12 Signaling Through Janus Kinase-STAT Pathway in T Lymphocytes

Evaluation of Efficacy of Curcumin as an Add-on therapy in Patients of Bronchial Asthma

Influence of Dietary Soy Phytoestrogens on Cytokine Production and Immunoglobulin in Ovariectomized Rats

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Curcumin inhibits Th1 cytokine profile in CD4+ T cells by suppressing interleukin‐12 production in macrophages

Cited by 107 publications

References 32 publications

Curcumin Inhibits Experimental Allergic Encephalomyelitis by Blocking IL-12 Signaling Through Janus Kinase-STAT Pathway in T Lymphocytes

Curcumin Inhibits Experimental Allergic Encephalomyelitis by Blocking IL-12 Signaling Through Janus Kinase-STAT Pathway in T Lymphocytes

Evaluation of Efficacy of Curcumin as an Add-on therapy in Patients of Bronchial Asthma

Influence of Dietary Soy Phytoestrogens on Cytokine Production and Immunoglobulin in Ovariectomized Rats

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Curcumin inhibits Th1 cytokine profile in CD4⁺ T cells by suppressing interleukin‐12 production in macrophages