Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-κB activation

Fattori, Victor; Pinho‐Ribeiro, Felipe A.; Borghi, Sérgio M.; Alves‐Filho, José C.; Cunha, Thiago M.; Cunha, Fernando Q.; Casagrande, Rúbia; Verri, Waldiceu A.

doi:10.1007/s00011-015-0885-y

Cited by 71 publications

(54 citation statements)

References 71 publications

(88 reference statements)

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“…20. ROS and LOPs have been reported to activate nuclear transcriptional factors, such as nuclear factor-erythroid 2–related factor 2, so as to alleviate pain 35,36. Finally, one study also speculated that ozone directly or indirectly acted on transmembrane proteins, intracellular cascades, and nuclear transcriptions to alleviate pain 37.…”

Section: Discussionmentioning

confidence: 99%

The effect and safety of ozone autohemotherapy combined with pharmacological therapy in postherpetic neuralgia

Hu¹,

Zheng²,

Liu³

et al. 2018

JPR

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IntroductionWe investigated the effect and safety of ozone autohemotherapy combined with pharmacological therapy in postherpetic neuralgia (PHN).MethodsNinety-eight patients with PHN were enrolled in this study and randomly divided into a pharmacological therapy group and ozone autohemotherapy group (49 patients in each group). The PHN patients in the pharmacological therapy group were administered pharmacological therapy for 2 weeks, whereas PHN patients in the ozone autohemotherapy group were given ozone autohemotherapy (200 mL blood from patients, the concentration of medical ozone was set as 30 μg/mL using an ozone medical apparatus, 40 mL medical ozone was incubated in 200 mL autologous blood for 3–5 minutes) combined with pharmacological therapy for 2 weeks. The Visual Analog Scale (VAS), the 50% VAS reduction in the initial value, McGill Pain Questionnaire (MPQ), the Patients’ Global Impression of Change (PGIC) scale, and the World Health Organization Quality of Life (WHOQOL-BREF) instrument were used to evaluate the outcomes of all PHN patients before therapy and at 1 week, 1 month, and 3 months after therapy.ResultsForty-five patients in the pharmacological therapy group and 47 patients in the ozone autohemotherapy group completed the study. Compared with before therapy, the two groups showed significant improvements in VAS, MPQ, PGIC, and WHOQOL-BREF scores after therapy (P<0.05). Moreover, compared with the scores of the pharmacological therapy group, the ozone autohemotherapy group’s scores were significantly improved in the VAS, MPQ, PGIC, and WHOQOL-BREF as well as the 50% VAS reduction of the initial value after therapy (P<0.05). Finally, there were no statistically significant differences in adverse effects between groups after therapy (P>0.05).ConclusionThe results of this study demonstrated that ozone autohemotherapy combined with pharmacological therapy was superior to isolated pharmacological therapy in patients with PHN and was an effective and safe way to relieve PHN.

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Section: Discussionmentioning

confidence: 99%

The effect and safety of ozone autohemotherapy combined with pharmacological therapy in postherpetic neuralgia

Hu¹,

Zheng²,

Liu³

et al. 2018

JPR

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“…If the anti-inflammatory and antioxidant effects of quercetin were directly and entirely interdependent, the anti-inflammatory effect would follow the same antioxidant structure relationship [5]. Nevertheless, the interaction of anti-inflammatory and antioxidant mechanisms is possible since cytokines induce free radical production and vice-versa [25]. The anti-inflammatory effects of quercetin have a great contribution of modulating the NFκB pathway.…”

Section: Discussionmentioning

confidence: 99%

“…Samples were homogenized in ice-cold buffer containing 1.15% KCl using a Polytron (PT3100) and centrifuged at 200 g in 4°C for 10 min [24,25]. The total antioxidant capacity of the supernatant was measured by ABTS assay, which is based on the ability of the tissue antioxidant molecules to quench ABTS radical cation (ABTS ⋅+ ), a bluegreen chromophore with characteristic absorption at 734 nm.…”

Section: Methodsmentioning

confidence: 99%

“…The supernatant was carefully removed, and the precipitated formazan was then solubilized by adding 120 μL of 2 M KOH and 140 μL of DMSO. Superoxide anion production was determined spectrophotometrically by the reduction of the redox dye NBT [21–25]. Readings were performed at 600 nm (Multiskan GO Microplate Spectrophotometer, Thermo Fischer Scientific, Vantaa, Finland).…”

Section: Methodsmentioning

confidence: 99%

“…Reverse transcription and quantitative polymerase chain reaction (qPCR) were performed as previously described [25]. Samples of the soleus muscle and spinal cord were homogenized in trizol reagent.…”

Section: Methodsmentioning

confidence: 99%

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Quercetin Inhibits Peripheral and Spinal Cord Nociceptive Mechanisms to Reduce Intense Acute Swimming-Induced Muscle Pain in Mice

et al. 2016

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The present study aimed to evaluate the effects of the flavonoid quercetin (3,3´,4´,5,7-pentahydroxyflavone) in a mice model of intense acute swimming-induced muscle pain, which resembles delayed onset muscle soreness. Quercetin intraperitoneal (i.p.) treatment dose-dependently reduced muscle mechanical hyperalgesia. Quercetin inhibited myeloperoxidase (MPO) and N-acetyl-β-D- glucosaminidase (NAG) activities, cytokine production, oxidative stress, cyclooxygenase-2 (COX-2) and gp91phox mRNA expression and muscle injury (creatinine kinase [CK] blood levels and myoblast determination protein [MyoD] mRNA expression) as well as inhibited NFκB activation and induced Nrf2 and HO-1 mRNA expression in the soleus muscle. Beyond inhibiting those peripheral effects, quercetin also inhibited spinal cord cytokine production, oxidative stress and glial cells activation (glial fibrillary acidic protein [GFAP] and ionized calcium-binding adapter molecule 1 [Iba-1] mRNA expression). Concluding, the present data demonstrate that quercetin is a potential molecule for the treatment of muscle pain conditions related to unaccustomed exercise.

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Combating silver nanoparticle‐mediated toxicity in Drosophila melanogaster with curcumin

Singh

Raj

Padmanabhan

et al. 2020

J of Applied Toxicology

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Nanoscale materials display unique physical and chemical properties that enable their assimilation into a variety of industrial and consumer products. Amongst the widely used nanomaterials, silver nanoparticles (AgNPs) have gained tremendous recognition for various applications, owing to their extraordinary plasmonic and bactericidal properties. Despite of the extensive usage of AgNPs in various sectors, its impact on human health remains ambiguous. Several studies have established that higher doses of AgNPs are detrimental to organismal health. In order to attain the best from these versatile nanoparticles, a recent advent of green nanotechnology, that is, employment of metal nanoparticles synthesized using plant extracts, has emerged. Here, using Drosophila as a model system, we tested if adding curcumin, a biologically active polyphenolic compound present in turmeric, having multitudes of therapeutic properties, could mitigate AgNP‐mediated biotoxicity. We found that co‐administration of AgNPs with curcumin in the fly food could alleviate several harmful effects evoked by AgNPs ingestion in Drosophila model. Addition of curcumin superseded reduction in feeding, pupation, eclosion, pigmentation, and fertility caused by AgNPs ingestion. Interestingly, impairment in ovary development observed in flies reared on AgNPs‐supplemented food was also partially restored by co‐administration of AgNPs with curcumin. Furthermore, substantial alleviation of reactive oxygen species level and cell death was observed in larval tissues upon co‐supplementation of AgNPs with curcumin. We therefore propose that curcumin, when administered with AgNPs, can abrogate the toxic manifestations of AgNPs ingestion and hence can be incorporated in various consumer products encompassing it.

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Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-κB activation

Abstract: Curcumin inhibits superoxide anion-induced inflammatory pain-like behaviors and leukocyte recruitment by targeting inflammatory molecules and oxidative stress; and inducing antioxidant and anti-inflammatory pathways.

Cited by 71 publications

References 71 publications

The effect and safety of ozone autohemotherapy combined with pharmacological therapy in postherpetic neuralgia

The effect and safety of ozone autohemotherapy combined with pharmacological therapy in postherpetic neuralgia

Quercetin Inhibits Peripheral and Spinal Cord Nociceptive Mechanisms to Reduce Intense Acute Swimming-Induced Muscle Pain in Mice

Combating silver nanoparticle‐mediated toxicity in Drosophila melanogaster with curcumin

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