Curcumin inhibits renal cyst formation and enlargement in vitro by regulating intracellular signaling pathways

Gao, Jie; Zhou, Hong; Lei, Tianluo; Zhou, Li; Li, Weidong; Li, Xuejun; Yang, Baoxue

doi:10.1016/j.ejphar.2010.12.008

Cited by 55 publications

(48 citation statements)

References 40 publications

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“…Consistent with this, two STAT3 inhibitors, pyrimethamine and S3I-201, inhibited cyst growth in a neonatal and an adult Pkd1 model (181). A similar protective effect was seen with curcumin, a compound with a broad spectrum of activity that also inhibits STAT3 (182,183).…”

Section: Activated Macrophages As a Treatment Target In Pkdsupporting

confidence: 55%

Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease

2014

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Recent advances in defining the genetic mechanisms of disease causation and modification in autosomal dominant polycystic kidney disease (ADPKD) have helped to explain some extreme disease manifestations and other phenotypic variability. Studies of the ADPKD proteins, polycystin-1 and -2, and the development and characterization of animal models that better mimic the human disease, have also helped us to understand pathogenesis and facilitated treatment evaluation. In addition, an improved understanding of aberrant downstream pathways in ADPKD, such as proliferation/secretion-related signaling, energy metabolism, and activated macrophages, in which cAMP and calcium changes may play a role, is leading to the identification of therapeutic targets. Finally, results from recent and ongoing preclinical and clinical trials are greatly improving the prospects for available, effective ADPKD treatments.

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Section: Activated Macrophages As a Treatment Target In Pkdsupporting

confidence: 55%

Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease

2014

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“…Numerous studies have indicated that curcumin is a highly pleiotropic molecule capable of treating various cancers. Our studies have proven that curcumin also has a significant inhibitory effect on renal cyst development [121] . Curcumin slowed cyst formation in both a MDCK cyst model and an embryonic kidney cyst model with a dose-dependent response.…”

Section: Curcuminmentioning

confidence: 99%

Drug discovery for polycystic kidney disease

2011

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In polycystic kidney disease (PKD), a most common human genetic diseases, fluid-filled cysts displace normal renal tubules and cause end-stage renal failure. PKD is a serious and costly disorder. There is no available therapy that prevents or slows down the cystogenesis and cyst expansion in PKD. Numerous efforts have been made to find drug targets and the candidate drugs to treat PKD. Recent studies have defined the mechanisms underlying PKD and new therapies directed toward them. In this review article, we summarize the pathogenesis of PKD, possible drug targets, available PKD models for screening and evaluating new drugs as well as candidate drugs that are being developed.

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“…Additionally, curcumin was tested in vivo and was shown to reduce cystogenesis via an alteration of STAT3 activation and proliferation in a iKSP-Pkd1del mouse model (55). This study indicated that curcumin might be a potential compound for the safe and effective therapy of PKD (54,55). In addition, in traditional Chinese medicine, triptolide has also been suggested to attenuate cyst formation by restoring Ca 2+ signaling in a Pkd1 -/-mice model (56).…”

Section: Other Approaches To Therapeutic Targets Of Pkdmentioning

confidence: 99%

“…Recently, many investigators are currently investigating novel approaches to therapy using natural compounds. Curcumin (diferuloylmethane), a natural product derived from the plant cucrcuma longa, was shown to inhibit MDCK cyst development (62%) and forskolin-promoted cell proliferation in MDCK cells, and also attenuated cystogenesis in embryonic kidney organ cultures (54). Additionally, curcumin was tested in vivo and was shown to reduce cystogenesis via an alteration of STAT3 activation and proliferation in a iKSP-Pkd1del mouse model (55).…”

Section: Other Approaches To Therapeutic Targets Of Pkdmentioning

confidence: 99%