Curcumin inhibits malignant behavior of colorectal cancer cells by regulating <scp>M2</scp> polarization of tumor‐associated macrophages and metastasis associated in colon cancer 1 (<scp>MACC1</scp>) expression

Ge, Shuke; Sun, Xu; Sang, Limin; Zhang, Min; Yan, Xubo; Ju, Qi; Ma, Xuefeng; Xu, Meng

doi:10.1111/cbdd.14330

Cited by 4 publications

(4 citation statements)

References 44 publications

(48 reference statements)

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“…Emerging evidence from both in vitro and in vivo studies suggests that curcumin exerts potent modulatory effects on macrophage polarization in inflammatory diseases, from cancer and autoimmune disorders to renal inflammation, stroke, and atherosclerosis [13]. While curcumin exhibits promising therapeutic potential, its poor solubility and bioavailability limit its clinical applications [48].…”

Section: Discussionmentioning

confidence: 99%

“…There is a close relationship between macrophages and tumors. Recently, Ge SK et al investigated the underlying mechanism of the antitumor effect of curcumin in colorectal cancer cells, focusing on the M2 polarization of tumor-associated macrophages (TAMs) [13]. They concluded that MACC1 and inhibition of M2 polarization of TAMs may mediate the antiproliferative and anti-migratory effects of curcumin in colorectal cancer cells.…”

Section: Introductionmentioning

confidence: 99%

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Synergizing Immune Balance: Curcumin Gold Nanoparticles and Ultrasound Irradiation for Macrophage Down-Regulation

Teixeira,

Gonçalves,

Vieira

et al. 2024

AppliedChem

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The multifaceted health benefits of curcumin (Curcuma longa), attributed to its antioxidant, antitumor, and anti-inflammatory activities, have drawn significant scientific attention. Curcumin shows promise as a potential modulator of macrophage polarization, offering a natural strategy for managing inflammation and promoting tissue repair. However, a limiting factor for this beneficial molecule is its limited bioavailability due to its low solubility in water. This study aimed to quantify the effect of curcumin gold nanoparticle (CurAuNP)-mediated ultrasound irradiation on THP-1-derived macrophages as potential therapeutic targets. The photoreduction method was applied to synthesize the gold nanoparticles with curcumin as a ligand (CurAu). The effect of adding polyethylene glycol in the synthesis process was studied (CurAuPEG). CurAuNP characterization included UV/Vis, Zeta potential, transmission electron microscopy, and FTIR. The amount of singlet oxygen released by curcumin and CurAuNPs was quantified by observing 1.3-diphenylisobenzofuran quenching upon ultrasound irradiation (1 MHz and 1 W/cm2). The results indicated that ultrasound therapy for 4 min with CurAuNPs significantly enhanced singlet oxygen generation and reduced macrophage viability compared to curcumin alone. The increased sonoluminescence and curcumin delivery facilitated by CurAuNPs led to greater curcumin activation. Consequently, CurAuNPs could offer promising therapeutic options for modulating macrophage polarization in pro-inflammatory and anti-inflammatory stages.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synergizing Immune Balance: Curcumin Gold Nanoparticles and Ultrasound Irradiation for Macrophage Down-Regulation

Teixeira,

Gonçalves,

Vieira

et al. 2024

AppliedChem

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“…TNBC cells (SUM159 or 4T1) were starved at 70% confluency for 24 h; then, the cell supernatants were collected and filtered through a 0.45 µm filter to remove cell debris and then stored at −20 • C for further use [55,57,58].…”

Section: Preparation Of Tumor-conditioned Medium (Tcm)mentioning

confidence: 99%

The Effect of Salvianolic Acid A on Tumor-Associated Macrophage Polarization and Its Mechanisms in the Tumor Microenvironment of Triple-Negative Breast Cancer

Tang,

Jiang,

et al. 2024

Molecules

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Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, with a high degree of malignancy and poor prognosis. Tumor-associated macrophages (TAMs) have been identified as significant contributors to the growth and metastasis of TNBC through the secretion of various growth factors and chemokines. Salvianolic acid A (SAA) has been shown to have anti-cancer activities. However, the potential activity of SAA on re-polarized TAMs remains unclear. As there is a correlation between the TAMs and TNBC, this study investigates the effect of SAA on TAMs in the TNBC microenvironment. For that purpose, M2 TAM polarization was induced by two kinds of TNBC-conditioned medium (TNBC-TCM) in the absence or presence of SAA. The gene and protein expression of TAM markers were analyzed by qPCR, FCM, IF, ELISA, and Western blot. The protein expression levels of ERK and p-ERK in M2-like TAMs were analyzed by Western blot. The migration and invasion properties of M2-like TAMs were analyzed by Transwell assays. Here, we demonstrated that SAA increased the expression levels of CD86, IL-1β, and iNOS in M2-like TAMs and, conversely, decreased the expression levels of Arg-1 and CD206. Moreover, SAA inhibited the migration and invasion properties of M2-like TAMs effectively and decreased the protein expression of TGF-β1 and p-ERK in a concentration-dependent manner, as well as TGF-β1 gene expression and secretion. Our current findings for the first time demonstrated that SAA inhibits macrophage polarization to M2-like TAMs by inhibiting the ERK pathway and promotes M2-like TAM re-polarization to the M1 TAMs, which may exert its anti-tumor effect by regulating M1/M2 TAM polarization. These findings highlight SAA as a potential regulator of M2 TAMs and the possibility of utilizing SAA to reprogram M2 TAMs offers promising insights for the clinical management of TNBC.

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“…8 Research reports that CUR plays a beneficial role in preventing, treating, and controlling cancer symptoms, such as breast cancer, colorectal cancer, prostate cancer, and melanoma. [9][10][11][12] Although CUR may enhance chemotherapy and chemotherapy prevention effects on cancer cells, it is safe and has almost no side effects even at high dose. 13 The evidence from the literature has indicated that CUR is an effective compound with antineoplastic effects.…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Curcumin Application to Melanoma in Mice

Teng,

Li,

Shi

et al. 2024

Ann Plast Surg

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Objective Melanoma is a skin tumor that poses a serious threat to human health. Our study explores the effectiveness and safety of curcumin in the treatment of melanoma based on animal models, and providing evidence-based medical evidence for curcumin in the treatment of malignant melanoma. Methods The study collected all randomized controlled trial data from the establishment of the database to October 2023 of curcumin for the treatment of melanoma in mice by searching PubMed, Embase, and the Cochrane Library. According to inclusion and exclusion criteria, data were extracted and quality assessment of included studies was performed by using the SYRCLE (Systematic Review Center for Laboratory animal Experimentation) animal experiment bias risk assessment tool. RevMan 5.4 and Stata 15.1 software were used for meta-analysis. Results Eighteen randomized controlled trials were included in this study with a total of 185 mouse models, including 93 mice in the experimental group and 92 in the control group. The results of meta-analysis showed that the IC50 (inhibitory concentrations of 50%) in the experimental group is lower than that of the control group [standardized mean difference (SMD) = −4.68, 95% confidence interval (CI) (−7.30, −2.06), P < 0.01]; the tumor volume is significantly smaller than the control group [SMD = −3.10, 95% CI (−4.45, −1.75), P < 0.01]; the tumor weight is smaller than the control group [SMD = −3.01, 95% CI (−4.81, −1.21), P < 0.01]. However, there was no significant statistical difference in the apoptosis rate between the experimental group and the control group [SMD = 2.27, 95% CI (−1.39, 5.92), P < 0.01]. Conclusion Based on animal models for meta-analysis, curcumin can inhibit the growth and proliferation of melanoma in mice. Melanoma may be an effective method for treating melanoma. However, this result still requires further in-depth research.

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Curcumin inhibits malignant behavior of colorectal cancer cells by regulating M2 polarization of tumor‐associated macrophages and metastasis associated in colon cancer 1 (MACC1) expression

Cited by 4 publications

References 44 publications

Synergizing Immune Balance: Curcumin Gold Nanoparticles and Ultrasound Irradiation for Macrophage Down-Regulation

Synergizing Immune Balance: Curcumin Gold Nanoparticles and Ultrasound Irradiation for Macrophage Down-Regulation

The Effect of Salvianolic Acid A on Tumor-Associated Macrophage Polarization and Its Mechanisms in the Tumor Microenvironment of Triple-Negative Breast Cancer

The Efficacy of Curcumin Application to Melanoma in Mice

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