Curcumin inhibits interferon-γ signaling in colonic epithelial cells

Midura-Kiela, Monica T.; Radhakrishnan, Vijayababu M.; Larmonier, Claire B.; Laubitz, Daniel; Ghishan, Fayez K.; Kiela, Pawel R.

doi:10.1152/ajpgi.00275.2011

Cited by 64 publications

(40 citation statements)

References 45 publications

(51 reference statements)

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“…Another study has found that the highest achieved peak serum concentration of curcumin in the peripheral blood was only 139 nM measured 4 hours after a single oral dose of 12 g curcumin 35 . Further, limited transepithelial flux and rapid metabolism in the gut epithelium are likely to impair curcumin exerting its beneficial effect locally on gut epithelium 36 . In our in vitro experiments, curcumin was delivered via DMSO, which would enhance delivery to the cell cytoplasm.…”

Section: All Authors Contributed To Conception and Design Manuscriptmentioning

confidence: 99%

Defining the therapeutic and preventative anti-inflammatory benefits of curcumin in vitro

Alhagamhmad¹,

Lemberg²,

Day³

et al. 2013

OA Inflammation

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IntroductionIn the setting of inflammatory bowel disease, curcumin supplementation to prevent inflammatory flares has shown promise. However, the outcome of curcumin exposure, when there is existing inflammation, is not clear. The aim of this study was to compare the anti-inflammatory properties of curcumin when added at differing times to an inflammatory stimulus, in an established in vitro intestinal epithelial cell model of intestinal inflammation. Materials and MethodsHT-29 and INT407 cells were incubated with a range of concentrations of curcumin prior to, or at the same time as, the addition of tumour necrosis factor-α. Following incubation, cell viability, interleukin-8 levels and cytoplasmic inhibitor of kappa B (IκB) were assessed. Results High concentrations of curcumin reduced epithelial cell viability. At lower concentrations, curcumin had no effect on cell viability; however, curcumin (with or without pre-incubation) reduced interleukin-8 levels and inhibited the phosphorylation and degradation of IκB. Conclusion Curcumin can reduce interleukin-8 and IκB response to tumour necro-

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Section: All Authors Contributed To Conception and Design Manuscriptmentioning

confidence: 99%

Defining the therapeutic and preventative anti-inflammatory benefits of curcumin in vitro

Alhagamhmad¹,

Lemberg²,

Day³

et al. 2013

OA Inflammation

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show abstract

“…The intestinal epithelium, an essential component of the gut innate defense mechanisms, is profoundly affected by interferon-γ, which can disrupt the epithelial barrier function, prevent epithelial cell migration and wound healing, as well as prime epithelial cells to express major histocompatibility complex class II molecules and to serve as nonprofessional antigen-presenting cells [43]. Recently, curcumin has also been shown to act as an interferon-γ-signaling inhibitor in colonocytes [43].…”

Section: Curcumin and Immune Functionmentioning

confidence: 99%

“…Recently, curcumin has also been shown to act as an interferon-γ-signaling inhibitor in colonocytes [43]. …”

Section: Curcumin and Immune Functionmentioning

confidence: 99%

Curcumin and Inflammatory Bowel Disease: Biological Mechanisms and Clinical Implication

Ali¹,

Shakir²,

Morton

2012

Digestion

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Increased recognition of the limits of conventional medicine has helped drive the growing interest in complementary and alternative medicine which is now being commonly used in patients with chronic diseases, including individuals with Crohn’s disease and ulcerative colitis. Recently, scientific interest has unraveled the beneficial pharmacological effects of curcumin. We present an updated concise review of currently available in vitro, animal and clinical studies demonstrating the therapeutic effect of herbal medication in inflammatory bowel disease.

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“…A high-calorie diet is the one of the major factors contributing to the development of obesity [3]. Specifically, it has been reported that administration of a high fat diet (HFD) results in abnormal lipid accumulation in the liver [4] and an increase in triglyceride, total cholesterol, and low density lipoprotein (LDL) in the blood serum [5]. It is very difficult to achieve weight loss and improve its abnormality once weight exceeds the normal range.…”

Section: Introductionmentioning

confidence: 99%

Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice

Lee

Kim

et al. 2014

Nutrients

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Codonopsis lanceolata extract (CLE) has been used in traditional medicine in the Asian-Pacific region for the treatment of bronchitis, cough, and inflammation. However, it is still unclear whether obesity in mice can be altered by diet supplementation with CLE. To investigate whether CLE could have preventative effects on high fat diet (HFD)-induced obesity, male C57BL/6 mice were placed on either a normal chow diet, 60% HFD, or a HFD supplemented with CLE (60, 180, and 360 mg/kg/day) for 12 weeks. CLE decreased body weight and subcutaneous and visceral fat weights in HFD-induced obese mice. CLE group mice showed lower fat accumulation and a smaller adipocyte area in the adipose tissue compared with the HFD group mice. CLE group mice exhibited lower serum levels of triglycerides, total cholesterol, low density lipoprotein (LDL), glucose, and insulin compared with the HFD group mice. In addition, CLE decreased liver weight and lowered the increase in aspartate aminotransferase (AST) and alanine transaminase (ALT) levels in HFD-induced obese mice. These results indicate that CLE can inhibit the development of diet-induced obesity and hyperlipidemia in C57BL/6 mice.

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Curcumin inhibits interferon-γ signaling in colonic epithelial cells

Abstract: Midura-Kiela MT, Radhakrishnan VM, Larmonier CB, Laubitz D, Ghishan FK, Kiela PR. Curcumin inhibits interferon-␥ signaling in colonic epithelial cells.

Cited by 64 publications

References 45 publications

Defining the therapeutic and preventative anti-inflammatory benefits of curcumin in vitro

Defining the therapeutic and preventative anti-inflammatory benefits of curcumin in vitro

Curcumin and Inflammatory Bowel Disease: Biological Mechanisms and Clinical Implication

Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice

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