Curcumin inhibits glutamate release in nerve terminals from rat prefrontal cortex: Possible relevance to its antidepressant mechanism

Antidepressant-like effects of magnesium lithospermate B in a rat model of chronic unpredictable stress

“…Inhibition of neuroinflammation may represent a novel mechanism of action for antidepressant treatment (Wong et al, 2008). Several recent studies have reported that some natural products such as omega-3 fatty acids and curcumin induced antidepressant effects through the modulation of oxidative reactions and inflammatory cytokine production in the brain (Lin et al, 2011;Su, 2009;Xu et al, 2005). The results of our and other previous studies led us to hypothesize that MLB may act as an antidepressant via regulating inflammatory responses.…”

Curcumin Inhibits Neuronal Loss in the Retina and Elevates Ca2+/Calmodulin-Dependent Protein Kinase II Activity in Diabetic Rats

“…It has been reported that curcumin protects neurons, including RGCs, from glutamate excitotoxicity. [35][36][37]56 In this study, we have found that curcumin reduces in vivo glutamate to nearly normal levels in the retina. Previous studies demonstrated that the release of glutamate could be directly inhibited by curcumin, possibly by suppressing the activity of mitogen-activated protein kinase (MAPK).…”

“…However, we believe that this mechanism is also involved in the regulation of glutamate levels. [35][36][37] Glutamate is the main excitatory neurotransmitter in the retina, but it is neurotoxic when present in excessive amounts. 53,54 Many research studies have reported that when glutamate is released in excess amounts, it over stimulates the N-methyl-D-aspartate receptor, promoting autophosphorylation and activation of CaMKII.…”

“…However, researchers have not yet been able to elucidate the mechanisms by which curcumin prevents the progression of diabetic retinopathy. [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] Although many studies have reported that curcumin rescues retinal neuronal cell cultures from glutamate toxicity, 36,37 researchers have not been able to determine how curcumin treatment ameliorates the diabetes-induced damage to retinal Department of Ophthalmology, Lishui Central Hospital and Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang Province, People's Republic of China. *These two authors contributed equally to the work and therefore should be considered equivalent authors.…”

Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects

“…Curcumin inhibited the release of glutamate evoked by exposing synaptosomes to the K + channel blocker 4-aminopyridine (4-AP) (Lin et al, 2011). Because the inhibitory effect of curcumin on glutamate release was completely abolished by the antidepressant fluoxetine, it was concluded that these two substances may use a common intracellular mechanism to inhibit glutamate release from rat prefrontal cortex nerve terminals.…”