Curcumin Inhibits Apoptosis and Brain Edema Induced by Hypoxia-Hypercapnia Brain Damage in Rat Models

Yu, Linsheng; Ye, Guanghua; Li, Junli; Xiao, Feng; Lin, Kuan‐Yu; Dong, Miuwu; Wang, Zhenyuan

doi:10.1097/maj.0000000000000457

Cited by 8 publications

(3 citation statements)

References 23 publications

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“…Yu et al . [ 23 ] have demonstrated that curcumin attenuated hypoxia-hypercapnia brain damage-induced apoptosis and brain edema in rat models. Wang et al .…”

Section: Discussionmentioning

confidence: 99%

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Curcumin targets vascular endothelial growth factor via activating the PI3K/Akt signaling pathway and improves brain hypoxic-ischemic injury in neonatal rats

Wang

et al. 2020

Korean J Physiol Pharmacol

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This study aimed to evaluate the effect of curcumin on brain hypoxicischemic (HI) damage in neonatal rats and whether the phosphoinositide 3-kinase (PI3K)/Akt/vascular endothelial growth factor (VEGF) signaling pathway is involved. Brain HI damage models were established in neonatal rats, which received the following treatments: curcumin by intraperitoneal injection before injury, insulin-like growth factor 1 (IGF-1) by subcutaneous injection after injury, and VEGF by intracerebroventricular injection after injury. This was followed by neurological evaluation, hemodynamic measurements, histopathological assessment, TUNEL assay, flow cytometry, and western blotting to assess the expression of p-PI3K, PI3K, p-Akt, Akt, and VEGF. Compared with rats that underwent sham operation, rats with brain HI damage showed remarkably increased neurological deficits, reduced right blood flow volume, elevated blood viscosity and haematocrit, and aggravated cell damage and apoptosis; these injuries were significantly improved by curcumin pretreatment. Meanwhile, brain HI damage induced the overexpression of p-PI3K, p-Akt, and VEGF, while curcumin pretreatment inhibited the expression of these proteins. In addition, IGF-1 treatment rescued the curcumin-induced down-regulated expression of p-PI3K, p-Akt, and VEGF, and VEGF overexpression counteracted the inhibitory effect of curcumin on brain HI damage. Overall, pretreatment with curcumin protected against brain HI damage by targeting VEGF via the PI3K/Akt signaling pathway in neonatal rats.

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“…Yu et al . [ 23 ] have demonstrated that curcumin attenuated hypoxia-hypercapnia brain damage-induced apoptosis and brain edema in rat models. Wang et al .…”

Section: Discussionmentioning

confidence: 99%

“…This suggests that curcumin was able to protect against brain HI damage in neonatal rats. Yu et al [23] induced apoptosis and brain edema in rat models. Wang et al [24] have reported that curcumin attenuates brain injuries induced by chronic intermittent hypoxia via regulating the expression of aquaporin 4 and the p38 MAPK pathway.…”

mentioning

confidence: 98%

Curcumin targets vascular endothelial growth factor via activating the PI3K/Akt signaling pathway and improves brain hypoxic-ischemic injury in neonatal rats

Wang

et al. 2020

Korean J Physiol Pharmacol

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“…Curcumin, a natural polyphenol found in the roots of Curcuma longa , is widely used in Ayurvedic medicine for centuries [ 8 – 9 ]. Although some studies have reported that curcumin can modulate kidney and myocardial I/R injury [ 10 – 11 ], however, the mechanisms by which curcumin regulates hepatic I/R injury remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Curcumin protects against hepatic ischemia/reperfusion induced injury through inhibiting TLR4/NF-κB pathway

Wang

Lin

et al. 2017

Oncotarget

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The TLR4/NF-κB pathway had important roles in hepatic ischemia/reperfusion (I/R) injury. In this study, we reported a protective effect of curcumin against hepatic I/R injury via TLR4/NF-κB pathway. Curcumin significantly inhibited cell apoptosis, and decreased levels of LDH and production of TNF-a, IL-1b, and IL-6 in the cell supernatant. In addition, curcumin ameliorated elevated TLR4 and NF-κB caused by hypoxia/reoxygenation stimulation in BRL-3A cells. In vivo assays revealed that curcumin reduce levels of ALT and AST, and reversed TLR4/NF-κB signaling pathway caused by hepatic I/R stimulation in liver tissues. These results suggested that curcumin ameliorates hepatic I/R injury, which may be mediated in part via the TLR4/NF-κB signaling pathway.

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The Chemistry and Biological Activities of Curcuminoids: Impacts on Neurological Disorders

Amalraj¹,

Sukumaran²,

Kunnumakkara

et al. 2019

Curcumin for Neurological and Psychiatric Disorders

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Curcumin Inhibits Apoptosis and Brain Edema Induced by Hypoxia-Hypercapnia Brain Damage in Rat Models

Cited by 8 publications

References 23 publications

Curcumin targets vascular endothelial growth factor via activating the PI3K/Akt signaling pathway and improves brain hypoxic-ischemic injury in neonatal rats

Curcumin targets vascular endothelial growth factor via activating the PI3K/Akt signaling pathway and improves brain hypoxic-ischemic injury in neonatal rats

Curcumin protects against hepatic ischemia/reperfusion induced injury through inhibiting TLR4/NF-κB pathway

The Chemistry and Biological Activities of Curcuminoids: Impacts on Neurological Disorders

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