Curcumin inhibited growth of human melanoma A375 cells via inciting oxidative stress

Xiang, Wei; Wang, Feifei; Wang, Rui; Ding, Yan

doi:10.1016/j.biopha.2017.09.026

Cited by 39 publications

(38 citation statements)

References 40 publications

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“…Interestingly, the same concentrations of CMC2.24 increased the generation of intracellular ROS, an important killing mechanism of phagocytized microorganisms. It is tempting to speculate that the inhibition of cytokine production and phagocytosis may aggravate the infectious process; whereas the increase in ROS production may also aggravate host tissue destruction if released extracellularly . However, it is important to consider that these apparently contradictory findings may be related with the final concentration of CMC2.24 in vivo and within the macrophages in vitro.…”

Section: Discussionmentioning

confidence: 99%

“…It is tempting to speculate that the inhibition of cytokine production and phagocytosis may aggravate the infectious process; whereas the increase in ROS production may also aggravate host tissue destruction if released extracellularly. 36 However, it is important to consider that these apparently contradictory findings may be related with the final concentration of CMC2.24 in vivo and within the macrophages in vitro. Other in vitro studies report contrasting effects of natural curcumin on production of ROS, depending on the cell type and concentration.…”

Section: Discussionmentioning

confidence: 99%

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Dose‐response assessment of chemically modified curcumin in experimental periodontitis

Brandão

Spolidorio

Johnson

et al. 2018

Journal of Periodontology

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Background CMC2.24, a novel tri‐ketonic chemically modified compound based on natural di‐ketonic curcumin, has been shown to reduce bone loss and inflammatory mediators in experimental periodontitis, however, a potential dose‐response relationship was not determined. The purpose of this study was to assess the effects of different doses of CMC2.24 on inflammation and bone resorption in vivo and also to describe on the effects of CMC2.24 on macrophage response. Methods CMC2.24 was administered daily to animals for 28 days by oral gavage, at the following doses: 0 (control), 1, 3, 10, and 30 mg/kg of body weight. Experimental periodontitis was induced by injections of lipopolysaccharide (LPS) into the gingival tissues. Outcomes assessed were bone resorption, detection of tartrate‐resistant acid phosphatase, and determination of gene expression. In vitro, macrophages (RAW264.7) were treated with different concentrations of CMC2.24: 1, 3, 10, and 30 μM and then subjected to different activation stimuli. Gene expression, phagocytic activity, production of reactive oxygen species (ROS) and cytokine production were evaluated. Results CMC2.24 inhibited bone resorption, osteoclastogenesis, and tumor necrosis factor (TNF)‐α expression in vivo. These beneficial responses reached maximum levels at a dose of 1 mg/kg, i.e. no dose‐dependent effect. In vitro, CMC2.24 reduced the production of TNF‐α and interleukin‐10, inhibited phagocytic activity and stimulated production of ROS. A dose‐dependent effect was observed only for ROS production. Conclusion Low doses of CMC2.24 (1 mg/kg/day) administered orally were sufficient to significantly inhibit alveolar bone resorption associated with the experimental periodontal disease; whereas in vitro macrophage inflammatory gene expression and phagocytosis were reduced, whereas production of ROS was stimulated.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dose‐response assessment of chemically modified curcumin in experimental periodontitis

Brandão

Spolidorio

Johnson

et al. 2018

Journal of Periodontology

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“…Curcumin inhibits cell growth, induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma EC1, EC9706, KYSE450, TE13 cells through STAT3 activation [12]. It also induces oxidative stress, which disrupts the mitochondrial membrane potential and causes the release of cytochrome c, thus inducing apoptosis [26]. Besides, curcumin is shown to induce autophagy [8,21,[27][28][29][30].…”

Section: Curcuminmentioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including antiproliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.

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“…Curcumin (Cur) is a hydrophobic polyphenol, derived from the plant curcuma longa (turmeric), with low intrinsic toxicity. It has been reported to possess a variety of pharmacologic effects, including antibacterial, anti-inflammatory, antioxidant, and antitumor properties [ 6 , 7 , 8 ]. However, curcumin is highly hydrophobic: the instability and poor bioavailability are major drawbacks for its further clinical application [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Curcumin-Loaded Solid Lipid Nanoparticles Enhanced Anticancer Efficiency in Breast Cancer

et al. 2018

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Curcumin (Cur) has been widely used in medicine, due to its antibacterial, anti-inflammatory, antioxidant, and antitumor effects. However, its clinic application is limited by its instability and poor solubility. In the present wok, curcumin was loaded into solid lipid nanoparticles (SLNs), in order to improve the therapeutic efficacy for breast cancer. The results measured using transmission electron microscopy (TEM) indicated that Cur-SLNs have a well-defined spherical shape; the size was about 40 nm with a negative surface charge. The drug loading and encapsulation efficiency in SLNs reached 23.38% and 72.47%, respectively. The Cur-SLNs showed a stronger cytotoxicity against SKBR3 cells. In vitro cellular uptake study demonstrated a high uptake efficiency of the Cur-SLNs by SKBR3 cells. Moreover, Cur-SLNs induced higher apoptosis in SKBR3 cells, compared to cells treated by free drug. In addition, Western blot analysis revealed that Cur-SLNs could promote the ratio of Bax/Bcl-2, but decreased the expression of cyclin D1 and CDK4. These results suggested that Cur-SLNs could be a potential useful chemotherapeutic formulation for breast cancer therapy.

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Curcumin inhibited growth of human melanoma A375 cells via inciting oxidative stress

Cited by 39 publications

References 40 publications

Dose‐response assessment of chemically modified curcumin in experimental periodontitis

Dose‐response assessment of chemically modified curcumin in experimental periodontitis

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Curcumin-Loaded Solid Lipid Nanoparticles Enhanced Anticancer Efficiency in Breast Cancer

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