Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells

Lewińska, Anna; Wnuk, Maciej; Grabowska, Wioleta; Ząbek, Tomasz; Semik, E.; Sikora, Ewa; Bielak-Żmijewska, Anna

doi:10.1016/j.toxlet.2015.01.019

Cited by 44 publications

(36 citation statements)

References 54 publications

(5 reference statements)

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“…The production of SBs in combination with ellagic acid was noted above [79]. Lewinska et al [81] reported a pro-oxidant effect of curcumin at concentrations of 10 μM (and below), indicated by an increase in 8-oxo–G in smooth muscle cells. Sebastia et al [80] compared effects of curcumin on human lymphocytes, both stimulated by TPA and unstimulated, and γ-irradiated.…”

Section: Isolated Phytochemicalsmentioning

confidence: 73%

Polyphenols and DNA Damage: A Mixed Blessing

Azqueta

Collins

2016

Nutrients

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Polyphenols are a very broad group of chemicals, widely distributed in plant foods, and endowed with antioxidant activity by virtue of their numerous phenol groups. They are widely studied as putative cancer-protective agents, potentially contributing to the cancer preventive properties of fruits and vegetables. We review recent publications relating to human trials, animal experiments and cell culture, grouping them according to whether polyphenols are investigated in whole foods and drinks, in plant extracts, or as individual compounds. A variety of assays are in use to study genetic damage endpoints. Human trials, of which there are rather few, tend to show decreases in endogenous DNA damage and protection against DNA damage induced ex vivo in blood cells. Most animal experiments have investigated the effects of polyphenols (often at high doses) in combination with known DNA-damaging agents, and generally they show protection. High concentrations can themselves induce DNA damage, as demonstrated in numerous cell culture experiments; low concentrations, on the other hand, tend to decrease DNA damage.

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Section: Isolated Phytochemicalsmentioning

confidence: 73%

Polyphenols and DNA Damage: A Mixed Blessing

Azqueta

Collins

2016

Nutrients

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“…The inhibitory effect of curcumin on vascular smooth muscle cell proliferation has been previously reported in various studies. 44,46,47 In addition, curcumin possesses anti-inflammatory effect which could also attenuate the inflammatory cytokineinduced cell apoptosis of vascular smooth muscle cells. 48,49 Our in vitro data suggest that curcumin has the potential to be used as an effective combination drug for relieving rapamycin-eluting stent-induced in-stent restenosis.…”

Section: Discussionmentioning

confidence: 99%

Curcumin Attenuates Rapamycin-induced Cell Injury of Vascular Endothelial Cells

Guo

Chen

Zhou

et al. 2015

Journal of Cardiovascular Pharmacology

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Although drug-eluting stents (DES) effectively improve the clinical efficacy of percutaneous coronary intervention, a high risk of late stent thrombosis and in-stent restenosis also exists after DES implantation. Anti-smooth muscle proliferation drugs, such as rapamycin, coating stents, not only inhibit the growth of vascular smooth muscle cells but also inhibit vascular endothelial cells and delay the reendothelialization. Therefore, the development of an ideal agent that protects vascular endothelial cells from rapamycin-eluting stents is of great importance for the next generation of DES. In this study, we demonstrated that rapamycin significantly inhibited the growth of rat aortic endothelial cells in both dose- and time-dependent manner in vitro. Cell apoptosis was increased and migration was decreased by rapamycin treatments in rat aortic endothelial cells in vitro. Surprisingly, treatment with curcumin, an active ingredient of turmeric, significantly reversed these detrimental effects of rapamycin. Moreover, curcumin increased the expression of vascular nitric oxide synthases (eNOS), which was decreased by rapamycin. Furthermore, caveolin-1, the inhibitor of eNOS, was decreased by curcumin. Knockdown of eNOS by small interfering RNA significantly abrogated the protective effects of curcumin. Taken together, our results suggest that curcumin antagonizes the detrimental effect of rapamycin on aortic endothelial cells in vitro through upregulating eNOS. Therefore, curcumin is a promising combined agent for the rescue of DES-induced reendothelialization delay.

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“…Other studies reported various effects of CUR to VSMCs, including inhibition of their proliferation [123], migration [124] and causing of the cytostatic effect at doses of only 5 µM [125]. These studies found that CUR stimulates the expression of caveolin-1 [122,123] and other molecular mechanisms such as blocking of NF-κB translocation and inhibition of matrix metalloproteinase (MMP-9) [124], or causing a cell cycle arrest by protein carbonylation, oxidative DNA damage and changes in the nucleolar activity, accompanied by elevated levels of p53 and p21 [125].…”

Section: Anti-atherosclerotic Effectmentioning

confidence: 99%

Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

Salehi

Prado-Audelo

Cortés

et al. 2020

JCM

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Cardiovascular diseases (CVD) compromises a group of heart and blood vessels disorders with high impact on human health and wellbeing. Curcumin (CUR) have demonstrated beneficial effects on these group of diseases that represent a global burden with a prevalence that continues increasing progressively. Pre-and clinical studies have demonstrated the CUR effects in CVD through its anti-hypercholesterolemic and anti-atherosclerotic effects and its protective properties against cardiac ischemia and reperfusion. However, the CUR therapeutic limitation is its bioavailability. New CUR nanomedicine formulations are developed to solve this problem. The present article aims to discuss different studies and approaches looking into the promising role of nanotechnology-based drug delivery systems to deliver CUR and its derivatives in CVD treatment, with an emphasis on their formulation properties, experimental evidence, bioactivity, as well as challenges and opportunities in developing these systems.

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Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells

Cited by 44 publications

References 54 publications

Polyphenols and DNA Damage: A Mixed Blessing

Polyphenols and DNA Damage: A Mixed Blessing

Curcumin Attenuates Rapamycin-induced Cell Injury of Vascular Endothelial Cells

Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

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