Curcumin Induces Apoptosis in Human Melanoma Cells through a Fas Receptor/Caspase-8 Pathway Independent of p53

Modulation of death receptors by cancer therapeutic agents

“…2), a plant product containing the phenolic phytochemical with apoptosis-inducing activity, has been demonstrated to increase Fas expression and induce Fas clustering in human melanoma cells, leading to the induction of apoptosis. 112 Curcumin also increased cell surface DR4 or DR5 and augmented TRAIL-induced apoptosis in prostate cancer 113 and renal cancer cells. 114 Although curcumin induced the expression of CHOP, suppression of CHOP expression by siRNA did not abrogate DR5 induction by curcumin and cell death induced by curcumin plus TRAIL, demonstrating that CHOP is not involved in curcumin-induced DR5 upregulation.…”

Optimal dietary protein level improved growth, disease resistance, intestinal immune and physical barrier function of young grass carp (Ctenopharyngodon idella)

“…However, other potential reasons are valuable to investigate further. In principle, death receptors pathway could initiate apoptosis [85], caspase 8 plays an important role in these pathway, and the inhibition of caspase 8 could inhibit apoptosis in human [86]. Bando et al [87] reported that inhibition of FasL could decrease caspase 8 activity in murine B lymphoma A20 cells.…”

Reduced Apaf-1 expression in human cutaneous melanomas

“…At 24 h after transfection, the cells were treated with 500 nM doxorubicin (DOX), 800 nM vincristine (VIN) or 200 nM camptothecin (CPT) (Sigma, Mississauga, Ontario, Canada) for another 24 h and the cell survival was determined by sulphorhodamine (SRB) assay (Bush et al, 2001). Briefly, the medium was removed and the cells were fixed with 10% trichloroacetate for 1 h at 41C, rinsed five times with water, and air-dried.…”