Curcumin Increase the Expression of Neural Stem/Progenitor Cells and Improves Functional Recovery after Spinal Cord Injury

Bang, Woo-Seok; Kim, Kyoung‐Tae; Seo, Ye Jin; Cho, Dae Chul; Sung, Joo Kyung; Kim, Chi Heon

doi:10.3340/jkns.2017.0203.003

Cited by 23 publications

(19 citation statements)

References 36 publications

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“…This effect indicates that curcumin exhibits antioxidant activity in wound healing. Studies have evaluated the effect of curcumin on wound healing in rats, and they found that the administration of curcumin enhanced wound healing, improved cell proliferation, and demonstrated an e cient free radical scavenging activity compared with the control and collagen treatments [16,17]. Furthermore, curcumin signi cantly suppresses TNF-αinduced neuroin ammation and the expression levels of IL-6, PGE2, and COX-2.…”

Section: Resultsmentioning

confidence: 99%

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Comparison of Curcumin and Methylprednisolone in Preventing Epidural Fibrosis After Spinal Surgery: An Experimental Study

Yildirim¹,

Yılmaz²,

Köktürk³

et al. 2020

Preprint

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Aim:We aimed to compare the effectiveness of curcumin, which has been shown to inhibit cell migration and proliferation, with that of methylprednisolone, which has been shown to have a similar mechanism of action to that of curcumin and to delay tissue repair and wound healing, in the prevention of epidural fibrosis in an experimental laminectomy model in rats.Material and methods:The experiment was conducted with 40 male Wistar rats weighing 250-300 g which were divided into four groups. Laminectomy was performed from L1 to L4 in all groups. Curcumin and methylprednisolone were applied to the other two groups except the control and Dmso groups. The vertebral colon was excised en bloc and each section was examined for epidural fibrosis formation under a light microscope to evaluate histologically using the grading system.Results:The statistical analyses indicated that the treatment groups had a significant effect on the histological grades of epidural fibrosis in rats compared to the control group.Discussion:Curcumin, derived from the rhizome (Rhizoma Curcumae) of turmeric (Curcuma longa) was found to show a significant effect in the prevention of epidural fibrosis formation with its potent antioxidant and anti-inflammatory properties and by inhibiting further recruitment of fibroblasts to the laminectomy area.Conclusions:In the present study, both histological examination and statistical analyses indicated that the administration of curcumin led to a remarkable reduction in epidural fibrosis after laminectomy.

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Section: Resultsmentioning

confidence: 99%

“…This nding may have been caused by the various effects of curcumin. Moreover, curcumin has been found to decrease posttraumatic in ammation owing to its anti-in ammatory properties in experimental spinal cord trauma studies [17,18].…”

Section: Resultsmentioning

confidence: 99%

Comparison of Curcumin and Methylprednisolone in Preventing Epidural Fibrosis After Spinal Surgery: An Experimental Study

Yildirim¹,

Yılmaz²,

Köktürk³

et al. 2020

Preprint

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“…For the prevention of EF progression, the most commonly used and recommended technique that causes less tissue damage is microsurgery (Zavyalov and Pretechikov, 2016). Given that microsurgery leads to less dead space in the efficient free radical scavenging activity compared with the control and collagen treatments (Gopinath et al, 2004;Bang et al, 2018). Furthermore, curcumin significantly suppresses TNF-α-induced neuroinflammation and the expression levels of IL-6, PGE2, and COX-2.…”

Section: Discussionmentioning

confidence: 99%

Comparison of curcumin and methylprednisolone in the prevention of epidural fibrosis after spinal surgery: An experimental study

YILDIRIM¹,

Yılmaz²,

KOKTÜRK³

et al. 2021

J Exp Clin Med

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We aimed to compare the effectiveness of curcumin, which has been shown to inhibit cell migration and proliferation, with that of methylprednisolone, which has been shown to have a similar mechanism of action to that of curcumin and to delay tissue repair and wound healing, in the prevention of epidural fibrosis in an experimental laminectomy model in rats. The experiment was conducted with 40 male Wistar rats weighing 250-300 g which were divided into four groups. Laminectomy was performed from L1 to L4 in all groups. Curcumin and methylprednisolone were applied to the other two groups except the control and DMSO groups. The vertebral colon was excised en bloc and each section was examined for epidural fibrosis formation under a light microscope to evaluate histologically using the grading system. Results: The statistical analyses indicated that the treatment groups had a significant effect on the histological grades of epidural fibrosis in rats compared to the control group. Curcumin, derived from the rhizome (Rhizoma Curcumae) of turmeric (Curcuma longa) was found to show a significant effect in the prevention of epidural fibrosis formation with its potent antioxidant and anti-inflammatory properties and by inhibiting further recruitment of fibroblasts to the laminectomy area. In the present study, both histological examination and statistical analyses indicated that the administration of curcumin led to a remarkable reduction in epidural fibrosis after laminectomy.

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“…Curcumin, which is the active component of turmeric, promotes sensorimotor function recovery via antiin ammation 35 , antioxidant 36 , and anti-apoptosis 37 effects in SCI. There were evidences showed that curcumin improved functional recovery from SCI by combined with the neural stem cells 38,39 or MSCs treatment 40 . The enhanced therapeutic effect was achieved by modulated the proliferation and differentiation of stem cells and alleviated the in ammation microenvironment in the injury region 41 .…”

Section: Discussionmentioning

confidence: 99%

Curcumin improves human umbilical cord derived mesenchymal stem cells survival and promotes motor outcome via ERK Signaling after spinal cord injury

Chen

et al. 2020

Preprint

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Abstract Background Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) transplantation are assumed as a promising strategy in spinal cord injury (SCI). However, the complex pathological microenvironment after SCI induces the apoptosis of hUC-MSCs, which limits the clinical application for the cell replacement therapy. Methods In this study, in order to investigate whether combined with curcumin could strengthen the therapeutic effects of hUC-MSCs transplantation for SCI, we mediated the apoptosis of hUC-MSCs with TNF-α and transplanted hUC-MSCs into SCI rats, followed by assessed the anti- apoptosis effect and mechanism of curcumin. Results LDH release test and flow cytometry demonstrated that TNF-α led to the hUC-MSCs apoptosis and curcumin increased survival rate of hUC-MSCs with dose-dependent. In addition, we showed that the phosphorylation levels of ERK, JNK and P38 were up-regulated in the hUC-MSCs apoptosis, while curcumin strengthened the phosphorylation of ERK, but not activated the JNK and P38, which was reversed by p42/44 antagonist U0126. Furthermore, we exhibited that the motor function scores and surviving HNA-positive cells were significantly increased after curcumin combined with hUC-MSCs transplantation therapy 8 weeks post SCI, while U0126 markedly attenuated these phenomenons. Conclusions The aforementioned data confirmed that curcumin suppressed the apoptosis of hUC-MSCs through ERK signal pathway and combined curcumin with hUC-MSCs treatment improved motor function after SCI in rats. The current research provides a strong basis for hUC-MSCs replacement therapy in conjunction with curcumin in the treatment and management of SCI in human.

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Curcumin Increase the Expression of Neural Stem/Progenitor Cells and Improves Functional Recovery after Spinal Cord Injury

Cited by 23 publications

References 36 publications

Comparison of Curcumin and Methylprednisolone in Preventing Epidural Fibrosis After Spinal Surgery: An Experimental Study

Comparison of Curcumin and Methylprednisolone in Preventing Epidural Fibrosis After Spinal Surgery: An Experimental Study

Comparison of curcumin and methylprednisolone in the prevention of epidural fibrosis after spinal surgery: An experimental study

Curcumin improves human umbilical cord derived mesenchymal stem cells survival and promotes motor outcome via ERK Signaling after spinal cord injury

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