Curcumin-Incorporated Biomaterials: In silico and in vitro evaluation of biological potentials

Torbat, Nasim Azari; Akbarzadeh, Iman; Rezaei, Niloufar; Moghaddam, Zahra Salehi; Bazzazan, Saba; Mostafavi, Ebrahim

doi:10.1016/j.ccr.2023.215233

Cited by 9 publications

(4 citation statements)

References 359 publications

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“…This suggests that the disassembly of the capsule layers allows an increase of POM in the media, which is responsible for the enhancement of the antioxidant activity of the system. The results achieved for the CUR-loaded capsules after irradiation are in accordance with the release profile achieved for the system, where the increase of CUR amount released to the media over time promoted an increase in the antioxidant activity of the system [ 17 , 19 , 20 , 24 ]. According to this, the proposed design antioxidant performance benefits from the synergistic contribution of VCO, POM, and CUR, being the formulation with higher antioxidant potential the one containing the disrupted CUR loaded capsules.…”

Section: Resultssupporting

confidence: 73%

“…For wound healing applications, many studies using nanoparticles to deliver CUR have shown significant improvements to the healing process compared to the isolated biomaterial or CUR alone [ 17 , 19 , 20 , 24 ]. It was also reported through in vitro studies, the reduced cytotoxic effect of CUR in human skin fibroblast when the CUR was combined within the biomaterial in the form of film, hydrogel, nanoparticles, liposomes, nanofibers, wafers, or sponges [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Chitosan/Virgin Coconut Oil-Based Emulsions Doped with Photosensitive Curcumin Loaded Capsules: A Functional Carrier to Topical Treatment

Rodrigues,

Ribeiro,

Silva

et al. 2024

Polymers

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In recent years, there has been a growing interest in developing smart drug delivery systems based on natural resources combined with stimulus-sensitive elements. This trend aims to formulate innovative and sustainable delivery platforms tailored for topical applications. This work proposed the use of layer-by-layer (LbL) methodology to fabricate biocompatible photo-responsive multilayer systems. These systems are composed of a polyoxometalate inorganic salt (POM) ([NaP5W30O110]14−) and a natural origin polymer, chitosan (CHT). Curcumin (CUR), a natural bioactive compound, was incorporated to enhance the functionality of these systems during the formation of hollow capsules. The capsules produced, with sizes between 2–5µm (SEM), were further dispersed into CHT/VCO (virgin coconut oil) emulsion solutions that were casted into molds and dried at 37 °C for 48 h. The system presented a higher water uptake in PBS than in acidic conditions, still significantly lower than that earlier reported to other CHT/VCO-based systems. The drug release profile is not significantly influenced by the medium pH reaching a maximum of 37% ± 1% after 48 h. The antioxidant performance of the designed structures was further studied, suggesting a synergistic beneficial effect resulting from CUR, POM, and VCO individual bioactivities. The increased amount of those excipients released to the media over time promoted an increase in the antioxidant activity of the system, reaching a maximum of 38.1% ± 0.1% after 48 h. This work represents a promising step towards developing advanced, sustainable drug delivery systems for topical applications.

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Section: Resultssupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Chitosan/Virgin Coconut Oil-Based Emulsions Doped with Photosensitive Curcumin Loaded Capsules: A Functional Carrier to Topical Treatment

Rodrigues,

Ribeiro,

Silva

et al. 2024

Polymers

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…16 However, poor stability, water solubility, and bioavailability have limited the clinical use of curcumin and stimulated intense research aimed at overcoming these issues through entrapment in nanocarriers. [17][18][19][20] Since hyperthermia enhances the anticancer activity of Cur, 21 photothermal nanosystems are interesting Cur delivery systems. 22 Two-component nanohybrid composites that integrate the properties of GO with nanoparticles or organic molecules were widely reported in the literature 23,24 and investigated for different applications including drug delivery, 25 NO photorelease, 26 and antibacterial 27 activity.…”

Section: Introductionmentioning

confidence: 99%

Red light-triggerable nanohybrids of graphene oxide, gold nanoparticles and thermo-responsive polymers for combined photothermia and drug release effects

Consoli,

Maugeri,

Forte

et al. 2024

J. Mater. Chem. B

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A Thermosensitive Hydrogel with Efficient NIR Photothermal Conversion as Injectable Wound Dressing for Accelerating Skin Wound Healing

Wu,

Wang,

Shen

et al. 2024

Adv Funct Materials

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Bacterial infection at wound sites can easily induce robust inflammation. M1 macrophages at wound sites can cause cascade inflammatory reactions to mediate a vicious inflammation cycle. Meanwhile, the hypoxia situation further aggravates the destruction and contraction of blood vessels in the wound microenvironment, therefore, hindering the infected wound healing process. Here, a thermosensitive hydrogel is reported to solve the above challenges by eliminating bacteria based on the photothermal effect, regulating the inflammatory immune microenvironment, and providing oxygen (O2). In vitro and in vivo experiments confirmed that the hydrogel has great O2‐producing properties. Based on the excellent photothermal properties of AIEgens, the hydrogel has a good bactericidal effect against S. aureus (100%) and E. coli (98.85%). The RNA‐sequencing revealed that Cur@AIE@MnO2/gel can interfere with the metabolic process and genetic material repair process to impact bacteria proliferation and biofilm dispersal, thus achieving excellent anti‐bacterial efficacy. Moreover, Cur@AIE@MnO2/gel can also up‐regulate anti‐inflammatory genes, down‐regulate pro‐inflammatory genes in macrophages, and facilitate the promotion of macrophage polarization from M1 to M2 to relieve inflammation. The therapeutic experiments show that this hydrogel accelerated the wound‐healing process. Therefore, this work may open new avenues for the development of novel dressings for bacterial‐infected wounds.

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Curcumin-Incorporated Biomaterials: In silico and in vitro evaluation of biological potentials

Cited by 9 publications

References 359 publications

Chitosan/Virgin Coconut Oil-Based Emulsions Doped with Photosensitive Curcumin Loaded Capsules: A Functional Carrier to Topical Treatment

Chitosan/Virgin Coconut Oil-Based Emulsions Doped with Photosensitive Curcumin Loaded Capsules: A Functional Carrier to Topical Treatment

Red light-triggerable nanohybrids of graphene oxide, gold nanoparticles and thermo-responsive polymers for combined photothermia and drug release effects

A Thermosensitive Hydrogel with Efficient NIR Photothermal Conversion as Injectable Wound Dressing for Accelerating Skin Wound Healing

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