Curcumin in Retinal Diseases: A Comprehensive Review from Bench to Bedside

Allegrini, Davide; Raimondi, Raffaele; Borgia, Alfredo; Sorrentino, Tania; Montesano, Giovanni; Tsoutsanis, Panagiotis; Cancian, Giuseppe; Verma, Yash; Rosa, Francesco Paolo De; Romano, Mario R.

doi:10.3390/ijms23073557

Cited by 7 publications

(6 citation statements)

References 107 publications

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“…In DR model systems, curcumin treatment resulted in an increase in antioxidant enzymes, upregulation of HO-1 and nrf2, reduction or inhibition of inflammatory mediators and growth factors, and inhibition of proliferation and migration of retinal endothelial cells, as evaluated in the different cell lines HRPC, HREC, and ARPE-19. In AMD experimental model systems, curcumin treatment resulted in the reduction of ROS, inhibition of apoptosis mediators and cellular inflammatory genes, and upregulation of the protective enzymes HO-1, thioredoxin, and NQO1 [ 186 , 187 ]. Clinical reports also corroborate the use and efficacy of curcumin in the treatment of ophthalmic pathologies [ 188 ].…”

Section: Nutraceuticals: Which Place In the Management Of Neovascular...mentioning

confidence: 99%

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Pharmacotherapy and Nutritional Supplements for Neovascular Eye Diseases

Rusciano

Bagnoli

2023

Medicina

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In this review, we aim to provide an overview of the recent findings about the treatment of neovascular retinal diseases. The use of conventional drugs and nutraceuticals endowed with antioxidant and anti-inflammatory properties that may support conventional therapies will be considered, with the final aim of achieving risk reduction (prevention) and outcome improvement (cooperation between treatments) of such sight-threatening proliferative retinopathies. For this purpose, we consider a medicinal product one that contains well-defined compound(s) with proven pharmacological and therapeutic effects, usually given for the treatment of full-blown diseases. Rarely are prescription drugs given for preventive purposes. A dietary supplement refers to a compound (often an extract or a mixture) used in the prevention or co-adjuvant treatment of a given pathology. However, it must be kept in mind that drug–supplement interactions may exist and might affect the efficacy of certain drug treatments. Moreover, the distinction between medicinal products and dietary supplements is not always straightforward. For instance, melatonin is formulated as a medicinal product for the treatment of sleep and behavioral problems; at low doses (usually below 1 mg), it is considered a nutraceutical, while at higher doses, it is sold as a psychotropic drug. Despite their lower status with respect to drugs, increasing evidence supports the notion of the beneficial effects of dietary supplements on proliferative retinopathies, a major cause of vision loss in the elderly. Therefore, we believe that, on a patient-by-patient basis, the administration of nutraceuticals, either alone or in association, could benefit many patients, delaying the progression of their disease and likely improving the efficacy of pharmaceutical drugs.

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Section: Nutraceuticals: Which Place In the Management Of Neovascular...mentioning

confidence: 99%

“…[ 202 , 203 ]. The efficacy of curcumin in proliferative retinal diseases has been thoroughly studied and reported [ 187 ].…”

Section: Nutraceuticals: Which Place In the Management Of Neovascular...mentioning

confidence: 99%

Pharmacotherapy and Nutritional Supplements for Neovascular Eye Diseases

Rusciano

Bagnoli

2023

Medicina

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“…Early evidence has shown that using curcumin as a therapeutic agent can help to improve the condition of patients with retinal diseases [ 139 , 140 , 141 , 142 ]. Many of these effects have been demonstrated using RPE cells and the retina of diabetic rats as models.…”

Section: Dietary Polyphenols: a Potential Strategy For Management Of ...mentioning

confidence: 99%

New Insights on Dietary Polyphenols for the Management of Oxidative Stress and Neuroinflammation in Diabetic Retinopathy

et al. 2023

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Diabetic retinopathy (DR) is a neurodegenerative and vascular pathology that is considered one of the leading causes of blindness worldwide, resulting from complications of advanced diabetes mellitus (DM). Current therapies consist of protocols aiming to alleviate the existing clinical signs associated with microvascular alterations limited to the advanced disease stages. In response to the low resolution and limitations of the DR treatment, there is an urgent need to develop more effective alternative therapies to optimize glycemic, vascular, and neuronal parameters, including the reduction in the cellular damage promoted by inflammation and oxidative stress. Recent evidence has shown that dietary polyphenols reduce oxidative and inflammatory parameters of various diseases by modulating multiple cell signaling pathways and gene expression, contributing to the improvement of several chronic diseases, including metabolic and neurodegenerative diseases. However, despite the growing evidence for the bioactivities of phenolic compounds, there is still a lack of data, especially from human studies, on the therapeutic potential of these substances. This review aims to comprehensively describe and clarify the effects of dietary phenolic compounds on the pathophysiological mechanisms involved in DR, especially those of oxidative and inflammatory nature, through evidence from experimental studies. Finally, the review highlights the potential of dietary phenolic compounds as a prophylactic and therapeutic strategy and the need for further clinical studies approaching the efficacy of these substances in DR management.

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“…Curcumin has preventive and therapeutic effects in diabetes, cancer, arthritis, anxiety, allergies, asthma, and many other diseases [ 8 ]. Recent studies have found that curcumin has great potential in the treatment of ocular diseases such as diabetic retinopathy, glaucoma, dry eye and age-related macular degeneration, which can alleviate the inflammatory response due to hyperglycemia and pathological neovascularization in DR [ 9 , 10 ]. It has been found that curcumin can modulate lysosomal activity in several tissues of diabetic rats and exert a lowering effect on blood glucose and urine glucose [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of curcumin in diabetic retinopathy: A protocol for systematic review and meta-analysis

Wang

et al. 2023

PLoS ONE

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Background Diabetic retinopathy (DR) is one of the most common complications of diabetes and has become a major global cause of blindness. Curcumin, an extract of Curcuma longa (turmeric), is effective in preventing and treating diabetes. Recent studies have shown that curcumin can delay DR development. However, there has been no systematic review of its treatment of DR. This study will conduct a systematic review and meta-analysis of currently published randomized controlled trials (RCT) of curcumin for treating DR patients to evaluate its efficacy and safety. Methods We will search the relevant studies of curcumin in the treatment of DR in PubMed, Medline, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP, and Wanfang databases from their respective inception dates to May 2022. A meta-analysis of the data extracted from qualified RCTs will be conducted, including the progression of DR, visual acuity, visual field, macular edema, quality of life, and adverse events. The meta-analysis will be performed using Review Manager 5.4.1 software, and the results will be based on either random-effects or fixed-effects models, depending on the heterogeneity. The Grading of Recommendations, Development, and Evaluation (GRADE) system will be used to evaluate the reliability and quality of evidence. Results The results of this study will provide sound and high-quality evidence for the efficacy and safety of curcumin in the treatment of DR. Conclusion This study will be the first meta-analysis to comprehensively assess the efficacy and safety of curcumin in the treatment of DR and will provide helpful evidence for the clinical management of this disease. Systematic review registration INPLASY202250002.

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Curcumin in Retinal Diseases: A Comprehensive Review from Bench to Bedside

Cited by 7 publications

References 107 publications

Pharmacotherapy and Nutritional Supplements for Neovascular Eye Diseases

Pharmacotherapy and Nutritional Supplements for Neovascular Eye Diseases

New Insights on Dietary Polyphenols for the Management of Oxidative Stress and Neuroinflammation in Diabetic Retinopathy

Efficacy and safety of curcumin in diabetic retinopathy: A protocol for systematic review and meta-analysis

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