Curcumin in Metabolic Health and Disease

Abstract

In recent years, epidemiological studies have suggested that metabolic disorders are nutritionally dependent. A healthy diet that is rich in polyphenols may be beneficial in the treatment of metabolic diseases such as polycystic ovary syndrome, metabolic syndrome, non-alcoholic fatty liver disease, cardiovascular disease, and, in particular, atherosclerosis. Curcumin is a polyphenol found in turmeric and has been reported to have antioxidant, anti-inflammatory, hepatoprotective, anti-atherosclerotic, and antidiabetic properties, among others. This review summarizes the influence of supplementation with curcumin on metabolic parameters in selected metabolic disorders.

Chemicolome and Metabolome Profiling of Xieriga-4 Decoction, A Traditional Mongolian Medicine, Using the UPLC-QTOF/MS Approach

“…CLR has been reported to exhibit anti-oxidant, anti-inflammatory, hepatoprotective, anti-atherosclerotic, and anti-diabetic properties [ 11 ]. Curcumins are the characteristic components in CLR, which is also a phenylpropanoid derivative and a member of the diketone family.…”

“…Curcumin is a characteristic component of CLR and exhibits anti-infammatory, antioxidation, antitumor, and immunoregulatory properties. Moreover, it improves insulin resistance, obesity, and other FFA-related diseases [11,[28][29][30][31]. In this study, isoquercetin and rutin were also screened as representative compounds.…”

Natural Compounds as Promising Adjuvant Agents in The Treatment of Gliomas

“…Currently, curcumin is largely used for its multiplex biological activities, which include anti-inflammatory activity, antioxidant activity, stem cell modulation, regulation of mitochondrial homeostasis, and neurogenesis [ 50 ]. Consequently, curcumin could be useful in the treatment of a large range of diseases, including metabolic, inflammatory, and cardiovascular ones [ 51 ]. In recent decades, natural compounds—and curcumin in particular—have gained growing interest in both experimental and preclinical studies for their beneficial effects on the central nervous system (CNS) [ 52 ].…”

Mechanisms Underlying Curcumin-Induced Neuroprotection in Cerebral Ischemia

“…It is challenging to dissolve, extract, and absorb curcumin, resulting in low bioavailability and limited clinical applications ( Esatbeyoglu et al, 2012 ; Kotha and Luthria, 2019 ). In recent years, numerous drug delivery systems using liposomes, nanoparticles, and microemulsion as carriers have been successfully developed, which significantly increased the solubility, stability, and safety of curcumin, and greatly improved its biological activity in treating or preventing diseases, showing great promise for clinical application ( Aggarwal and Sung, 2009 ; Mahmood et al, 2015 ; Abd El-Hack et al, 2021 ; Jabczyk et al, 2021 ; Feltrin et al, 2022 ).…”

“…( Zhou et al, 2011 ; Mandal et al, 2020 ; Fu et al, 2021 ). Numerous studies have revealed the beneficial role of curcumin in cancer, diabetes, metabolic diseases, autoimmune diseases, atherosclerosis, arthritis, pulmonary diseases, etc ( Aggarwal and Harikumar, 2009 ; Jabczyk et al, 2021 ; Mahjoob and Stochaj, 2021 ). Recently, researchers discovered that curcumin also has neuroprotective effects on various neurological diseases, including neuropsychiatric disorders, neurodegenerative diseases, traumatic brain injury, spinal cord injury, and epilepsy ( Dhir, 2018 ; Bhat et al, 2019 ; Yavarpour-Bali et al, 2019 ; Yuan et al, 2019 ; Farkhondeh et al, 2020 ; Nebrisi, 2021 ; Lamanna-Rama et al, 2022 ).…”