Curcumin in heart failure: A choice for complementary therapy?

Saeidinia, Amin; Keihanian, Faeze; Butler, Alexandra E.; Bagheri, Ramin Khameneh; Atkin, Stephen L.

doi:10.1016/j.phrs.2018.03.009

Cited by 42 publications

(20 citation statements)

References 103 publications

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“…ere are so many preclinical researches on turmeric use for a wide variety of cardiovascular diseases such as myocardial infarction, heart failure, cardiac hypertrophy, atherosclerosis, stroke, abdominal aortic aneurysm, druginduced cardiotoxicity, and cardiomyopathy, and diabetes mellitus related cardiovascular problems. Also, there are a number of clinical trials about the efficacy of curcumin on cardiovascular risk factors [126][127][128].…”

Section: Effects On Metabolic Syndrome Related Disorders and Cardiomentioning

confidence: 99%

Biochemistry, Safety, Pharmacological Activities, and Clinical Applications of Turmeric: A Mechanistic Review

Ahmad

Hussain

Sultan³

et al. 2020

Evidence-Based Complementary and Alternative Medicine

102

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Turmeric (Curcuma longa L.) is a popular natural drug, traditionally used for the treatment of a wide range of diseases. Its root, as its most popular part used for medicinal purposes, contains different types of phytochemicals and minerals. This review summarizes what is currently known on biochemistry, safety, pharmacological activities (mechanistically), and clinical applications of turmeric. In short, curcumin is considered as the fundamental constituent in ground turmeric rhizome. Turmeric possesses several biological activities including anti-inflammatory, antioxidant, anticancer, antimutagenic, antimicrobial, antiobesity, hypolipidemic, cardioprotective, and neuroprotective effects. These reported pharmacologic activities make turmeric an important option for further clinical research. Also, there is a discussion on its safety and toxicity.

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Section: Effects On Metabolic Syndrome Related Disorders and Cardiomentioning

confidence: 99%

Biochemistry, Safety, Pharmacological Activities, and Clinical Applications of Turmeric: A Mechanistic Review

Ahmad

Hussain

Sultan³

et al. 2020

Evidence-Based Complementary and Alternative Medicine

102

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“…In some pre-clinical studies, CUR has shown efficacy and activity in heart failure treatment. This effect is attributable to inhibition of cardiomyocyte fibrosis, improvement in ventricular hypertrophy, and related-gene expression [57]. Other CUR cardio-protective potentials are used in myocardial ischemia/reperfusion injury, diabetic cardiomyopathy, arrhythmia, hypertrophic cardiomyopathy, and doxorubicin-related cardiotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

Salehi

Prado-Audelo

Cortés

et al. 2020

JCM

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Cardiovascular diseases (CVD) compromises a group of heart and blood vessels disorders with high impact on human health and wellbeing. Curcumin (CUR) have demonstrated beneficial effects on these group of diseases that represent a global burden with a prevalence that continues increasing progressively. Pre-and clinical studies have demonstrated the CUR effects in CVD through its anti-hypercholesterolemic and anti-atherosclerotic effects and its protective properties against cardiac ischemia and reperfusion. However, the CUR therapeutic limitation is its bioavailability. New CUR nanomedicine formulations are developed to solve this problem. The present article aims to discuss different studies and approaches looking into the promising role of nanotechnology-based drug delivery systems to deliver CUR and its derivatives in CVD treatment, with an emphasis on their formulation properties, experimental evidence, bioactivity, as well as challenges and opportunities in developing these systems.

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“…Over the last 60 years, numerous studies have demonstrated that curcumin can be used to treat a wide variety of diseases like cancer (Momtazi & Sahebkar, b; Teymouri, Pirro, Johnston, & Sahebkar, ), type 2 diabetes (Panahi et al, a; Panahi et al, ), neurodegenerative disease (Ghosh, Banerjee, & Sil, ; Monroy, Lithgow, & Alavez, ), hepatic disorders (Alappat & Awad, ; El‐Agamy, ; Panahi et al, ; Panahi et al, b; Rahmani et al, ; Zabihi, Pirro, Johnston, & Sahebkar, ), cardiovascular disease (Cicero et al, ; Ganjali et al, ; Saeidinia et al, ), metabolic disorders (Panahi, Khalili, Hosseini, Abbasinazari, & Sahebkar, a; Sahebkar, ), arthritis (Panahi et al, ; Sahebkar & Henrotin, ), autoimmune disease (Abdollahi, Momtazi, Johnston, & Sahebkar, ; Lelli, Sahebkar, Johnston, & Pedone, ; Momtazi‐Borojeni et al, ), pulmonary disorders (Lelli et al, ), thrombotic disorders (Keihanian, Saeidinia, Bagheri, Johnston, & Sahebkar, ), and inflammatory diseases (Chandran & Goel, ; Funk et al, ; Funk et al, ). Curcumin possesses antioxidant, antibacterial, antifungal, antiviral, and antiatherosclerotic properties.…”

Section: Introductionmentioning

confidence: 99%

Demethoxycurcumin: A naturally occurring curcumin analogue for treating non‐cancerous diseases

Hatamipour

Ramezani

Tabassi

et al. 2019

Journal Cellular Physiology

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Turmeric extracts contain three primary compounds, which are commonly referred to as curcuminoids. They are curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin. While curcumin has been the most extensively studied of the curcuminoids, it suffers from low overall oral bioavailability due to extremely low absorption as a result of low water solubility and instability at acidic pH, as well as rapid metabolism and clearance from the body. However, DMC, which lacks the methoxy group on the benzene ring of the parent structure, has much greater chemical stability at physiological pH and has been recently reported to exhibit antitumor properties. However, the treatment of noncancerous diseases with DMC has not been comprehensively reviewed. Therefore, here we evaluate published scientific literature on the therapeutic properties of DMC. The beneficial pharmacological actions of DMC include anti-inflammatory, neuroprotective, antihypertensive, antimalarial, antimicrobial, antifungal, and vasodilatory properties. In addition, DMC's ability to ameliorate the effects of free radicals and an environment characterized by oxidative stress caused by the accumulation of advanced glycation end-products associated with diabetic nephropathy, as well as DMC's capacity to inhibit the migration and proliferation of vascular smooth muscle cells following balloon angioplasty are also addressed. This review collates the available literature regarding the therapeutic possibilities of DMC in noncancerous conditions.

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Curcumin in heart failure: A choice for complementary therapy?

Cited by 42 publications

References 103 publications

Biochemistry, Safety, Pharmacological Activities, and Clinical Applications of Turmeric: A Mechanistic Review

Biochemistry, Safety, Pharmacological Activities, and Clinical Applications of Turmeric: A Mechanistic Review

Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

Demethoxycurcumin: A naturally occurring curcumin analogue for treating non‐cancerous diseases

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