Curcumin improves neural function after spinal cord injury by the joint inhibition of the intracellular and extracellular components of glial scar

Yuan, Jianmin; Zou, Mingming; Xiang, Xin; Zhu, Haitao; Chu, Weihua; Liu, Wei; Chen, Fei; Lin, Jiangkai

doi:10.1016/j.jss.2014.12.055

Cited by 54 publications

(29 citation statements)

References 36 publications

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“…Many investigators subsequently confirmed beneficial effects of treatments that break down or reduce CSPG production [32,79,93,113,116,125,152,161,195,360,361]. In 2006, Barritt et al reported that ChABC promotes sprouting in intact and injured spinal cords [16].…”

Section: Proteoglycansmentioning

confidence: 99%

Rehabilitative Surgery

2017

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Section: Proteoglycansmentioning

confidence: 99%

Rehabilitative Surgery

2017

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“…Many factors protect neurons through the inhibition of pro-inflammatory cytokines IL-1β, such as erythropotein [34], fullerenols and glucosamine fluerences [35], omega-3 polyunsaturated fatty acids [36], and curcumin [37] [38]. In addition, recent evidence using a MAPKs inhibitor [39] and an IL-1β receptor antagonist [28] suggest that these may act as anti-inflammatory drugs.…”

Section: Discussionmentioning

confidence: 99%

Effect of Interleukin-1Beta (IL-1<i>β</i>) on the Cortical Neurons Survival and Neurites Outgrowth

Abd-El-Basset¹

2016

ABB

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Insults to the brain are known to cause a myriad of downstream effects, including the release of cytokines by astrocytes and resultant reactive gliosis. The author has examined effect of cytokine IL-1β on the survival of cortical neurons using mouse astrocyte-neuron co-culture. Five groups were used. These were neurons alone (Group 1), neurons with added IL-1β (Group 2), neurons co-cultured with astrocytes (Group 3), neurons co-cultured with astrocytes that was pre-treated with IL-1β before co-culture (Group 4) and neurons co-cultured with astrocytes and IL-1β added (post-treated) (Group 5). In Group 1 only a few neurons grew and survived only for 5-6 days. In Group 2, it was observed that more neurons survived up to 11 days. Moreover, in Group 3, more neurons grew and survived up to 16-18 days. They had large cell bodies and many long neurites that formed anastomosing networks. In Group 4, few neurons survived up to 13 days, whereas in Group 5, the growth of neurons were affected but to a much lesser extent than Group 4 and survived up to 15 days. In addition, it was found that IL-1β stimulated the expression of glial fibrillary acidic protein (GFAP) by astrocytes. This study indicates that IL-1β affects the survival of cortical neurons and modulates the astrocytic support to neuronal survival and neurites outgrowth by acting directly on the astrocytes.

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“…The expression of GFAP and CSPG proteins is significantly suppressed by curcumin which inhibits the glial scar's formation both intracellularly and extracellularly and ameliorates the microenvironment for axon's regeneration [71–73]. CDGSH iron sulfur domain 2 (CISD2) was regarded as a survival gene like bcl-2 and also known to have role in antiapoptosis, which was showed to exert antiapoptotic effect in neural cells.…”

Section: Curcumin Inhibits Glial Scar Formation and Apoptosis Aftementioning

confidence: 99%

“mTOR Signaling Pathway”: A Potential Target of Curcumin in the Treatment of Spinal Cord Injury

Lin

Huo

Liu

2017

BioMed Research International

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The purpose of this review is to discuss the possibility of the treatment of spinal cord injury (SCI) with curcumin via regulating the mTOR signaling pathway, which may provide another strong support for curcumin to be a promising medicine applied to the treatment of SCI. Curcumin is termed as a multifunctional targeting therapy drug that regulates the mTOR signaling pathway in the treatment of numerous diseases. Previous research has already revealed that mTOR signaling pathway plays a vital role in prognosis, which involves the axon regeneration and autophagy. This review discusses a potential mechanism that curcumin suppresses the activation of this pathway and ameliorates the microenvironment of axons regeneration which would provide a new way that induces autophagy appropriately.

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Curcumin improves neural function after spinal cord injury by the joint inhibition of the intracellular and extracellular components of glial scar

Cited by 54 publications

References 36 publications

Rehabilitative Surgery

Rehabilitative Surgery

Effect of Interleukin-1Beta (IL-1<i>β</i>) on the Cortical Neurons Survival and Neurites Outgrowth

“mTOR Signaling Pathway”: A Potential Target of Curcumin in the Treatment of Spinal Cord Injury

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Curcumin improves neural function after spinal cord injury by the joint inhibition of the intracellular and extracellular components of glial scar

Cited by 54 publications

References 36 publications

Rehabilitative Surgery

Rehabilitative Surgery

Effect of Interleukin-1Beta (IL-1&lt;i&gt;β&lt;/i&gt;) on the Cortical Neurons Survival and Neurites Outgrowth

“mTOR Signaling Pathway”: A Potential Target of Curcumin in the Treatment of Spinal Cord Injury

Contact Info

Product

Resources

About

Effect of Interleukin-1Beta (IL-1<i>β</i>) on the Cortical Neurons Survival and Neurites Outgrowth