Curcumin improves learning and memory ability and its neuroprotective mechanism in mice

Pan, Rui; Qiu, Sheng; Lu, Daxiang; Dong, Jing

doi:10.1097/00029330-200805010-00015

Cited by 102 publications

(40 citation statements)

References 29 publications

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“…CUR is non-toxic and has been shown to be a potent free radical scavenger [24,25]. In addition, CUR, like other polyphenols commonly found in plants, fruits and vegetables, competes in efficacy with vitamins C and E [26], although recent findings have attributed part of its anti-inflammatory efficacy to its more stable metabolite tetrahydrocurcumin [27].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity

Carmona-Ramírez

Santamarı́a

Tobón-Velasco

et al. 2013

The Journal of Nutritional Biochemistry

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity

Carmona-Ramírez

Santamarı́a

Tobón-Velasco

et al. 2013

The Journal of Nutritional Biochemistry

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“…Pan and colleagues (2008) [117] studied the effects of memory improving properties of curcumin mice and investigated the neuroprotective effect of curcumin in vitro and in vivo . The mice were given AlCl (3) orally and injections of D-galactose intraperitoneally for 90 days to establish the AD animal model.…”

Section: Research On Curcumin In Mouse Models Of Alzheimer’s Diseasementioning

confidence: 99%

“…This study demonstrates that curcumin improves the memory ability of AD mice and inhibits apoptosis in cultured PC12 cells induced by AlCl (3). They conclude that the mechanism may involve enhancing the level of Bcl-2 [117]. …”

Section: Research On Curcumin In Mouse Models Of Alzheimer’s Diseasementioning

confidence: 99%

Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease

Reddy

Mańczak

Yin

et al. 2018

JAD

274

138

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The purpose of our article is to assess the current understanding of Indian spice ‘Curcumin’ against amyloid-β (Aβ)-induced toxicity in Alzheimer’s disease (AD) pathogenesis. Natural products, such as ginger, curcumin and gingko biloba have been used as diets and dietary supplements to treat human diseases, including cancer, cardiovascular, respiratory, infectious, diabetes, obesity, metabolic syndromes and neurological disorders. Products derived from plants are known to have protective effects, including anti-inflammatory, anti-oxidant, anti-arthritis, pro-healing and boosting memory cognitive functions. In the last decade, several groups have designed and synthesized curcumin and its derivatives and extensively tested using cell and mouse models of AD. Recent research on amyloid-β and curcumin has revealed that curcumin prevents amyloid-β aggregation and crosses the blood brain barrier (BBB), reach brain cells and protect neurons from various toxic insults of aging and amyloid-β in humans. Recent research has also reported that curcumin ameliorates cognitive decline and improves synaptic functions in mouse models of AD. Further, recent groups have initiated studies on elderly individuals and patients with AD and the outcome of these studies is currently being assessed. This article highlights the beneficial effects of curcumin on AD. This article also critically assesses the current limitations of curcumin’s bioavailability and urgent need for new formulation to increase its brain levels to treat patients with AD.

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“…Various drugs/compounds have been examined for their role against aluminium-induced neurotoxicity in rat and mice models (Gong et al 2005;Jyoti et al 2007;Luo et al 2007;Pan et al 2008). In the recent studies, lithium has been shown to exert neuroprotective effects against various stimuli both in vitro and in vivo (Li et al 2002;Yuan et al 2004;Aghdam et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Potential of lithium to reduce aluminium-induced cytotoxic effects in rat brain

2009

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The present study was aimed to explore the potential of an antidepressant drug lithium (Li) in reducing aluminium (Al) induced neurotoxicity. To carry out the investigations, Al was administered orally (100 mg AlCl(3)/Kg b wt/day) whereas, Li was administered through diet (1.1 g Li(2)CO(3)/Kg diet, daily) for a total duration of 2 months. Al treatment resulted in a significant increase in the activity of enzyme nitric oxide synthase and the levels of L-citrulline which, however, were decreased appreciably following lithium supplementation. Al treatment also revealed an increase in DNA fragmentation as evidenced by an increase in number of comets. Interestingly, Li supplementation to Al treated rats reduced the damage inflicted on DNA by Al. Ultrastructural studies revealed an increase in chromatin condensation with discontinuity in nuclear membrane in both the cerebrum and cerebellum of Al treated rats which showed improvement following Li supplementation. Alterations in the structure of synapse and mitochondrial swelling were also seen. The present study shows the potential of Li in containing the damage inflicted by Al on rat brain.

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Curcumin improves learning and memory ability and its neuroprotective mechanism in mice

Cited by 102 publications

References 29 publications

RETRACTED: Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity

RETRACTED: Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity

Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease

Potential of lithium to reduce aluminium-induced cytotoxic effects in rat brain

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