Curcumin Heals Indomethacin-Induced Gastric Ulceration by Stimulation of Angiogenesis and Restitution of Collagen Fibers<i>via</i>VEGF and MMP-2 Mediated Signaling

Sharma, Anamika Vivek; Ganguly, Krishnendu; Paul, Surojit; Maulik, Nilanjana; Swarnakar, Snehasikta

doi:10.1089/ars.2011.4232

Cited by 56 publications

(23 citation statements)

References 35 publications

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“…The epithelialization period of the treated wounds showed a significant decrease from 23 to 11 days. 33 Similarly, a marked difference was observed in the tensile strength of tissues from the control and experimental incision wounds. A significant increase of 129% in tensile strength was observed on the 8th day in curcumin-treated groups.…”

Section: Role Of Phytochemicals In Skin Regenerationmentioning

confidence: 89%

“…Furthermore, this study also substantiates that the topical administration of curcumin was found to improve all the phases of wound repair, including collagen synthesis and maturation, wound contraction, and epithelialization. 33 Furthermore, several other investigators also showed that curcumin accelerates the healing of gastric ulcers by reepithelialization, by demonstrating glutathione depletion, lipid peroxidation, and protein oxidation. 28,34,35 Enhanced cell proliferation and an increase in free radicals was also observed in curcumin treatment, which reduces the wound of ulcers.…”

Section: Role Of Phytochemicals In Skin Regenerationmentioning

confidence: 98%

“…This demonstrates curcumin-mediated faster healing and remodeling of gastric tissues by restoring the collagen architecture and accelerating angiogenesis. 33 The curcumin-treated wounds were found to contract much faster. The epithelialization period of the treated wounds showed a significant decrease from 23 to 11 days.…”

Section: Role Of Phytochemicals In Skin Regenerationmentioning

confidence: 99%

“…Sharma et al examined the molecular mechanism of curcumin in a preventive and therapeutic model of indomethacin-induced gastric ulceration with regard to angiogenic processes. 33 Impaired blood vessels, dwindled collagen matrices, and trivial injury to mucosal cells were observed during ulceration. They showed that curcumin can block the ulceration by inducing collagenization and angiogenesis in gastric tissues via up-regulation of matrix metalloproteinase-2 (MMP-2), membrane type 1-MMP, vascular endothelial growth factor (VEGF), and TGF-b in blood vessels.…”

Section: Role Of Phytochemicals In Skin Regenerationmentioning

confidence: 99%

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Phytochemicals in Wound Healing

Thangapazham

Sharad

Maheshwari

2016

Advances in Wound Care

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Traditional therapies, including the use of dietary components for wound healing and skin regeneration, are very common in Asian countries such as China and India. The increasing evidence of health-protective benefits of phytochemicals, components derived from plants is generating a lot of interest, warranting further scientific evaluation and mechanistic studies. Phytochemicals are non-nutritive substances present in plants, and some of them have the potential to provide better tissue remodeling when applied on wounds and to also act as proangiogenic agents during wound healing. In this review, we briefly discuss the current understanding, important molecular targets, and mechanism of action(s) of some of the phytochemicals such as curcumin, picroliv, and arnebin-1. We also broadly review the multiple pathways that these phytochemicals regulate to enhance wound repair and skin regeneration. Recent experimental data on the effects of phytochemicals on wound healing and skin regeneration establish the potential clinical utility of plant-based compounds. Additional research in order to better understand the exact mechanism and potential targets of phytochemicals in skin regeneration is needed. Human studies a2nd clinical trials are pivotal to fully understand the benefits of phytochemicals in wound healing and skin regeneration.

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Section: Role Of Phytochemicals In Skin Regenerationmentioning

confidence: 89%

Section: Role Of Phytochemicals In Skin Regenerationmentioning

confidence: 98%

Section: Role Of Phytochemicals In Skin Regenerationmentioning

confidence: 99%

Section: Role Of Phytochemicals In Skin Regenerationmentioning

confidence: 99%

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Phytochemicals in Wound Healing

Thangapazham

Sharad

Maheshwari

2016

Advances in Wound Care

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“…(5,6). Curcumin is a polyphenol, derived from the plant Curcuma longa, and has also been investigated as a promising therapy for cancer, infection and dementia (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Curcumin-induced histone acetylation inhibition improves stress-induced gastric ulcer disease in rats

Zhou

et al. 2014

Molecular Medicine Reports

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Curcumin is known to possess anti‑inflammatory properties. Despite the fact that curcumin is known to be a strong inhibitor of H+, K+‑ATPase activity, the mechanism underlying the curcumin‑induced inhibition of the transcription of the H+, K+‑ATPase α subunit in gastric mucosal parietal cells remains unclear. The present study investigated the possible mechanism by which curcumin inhibits stomach H+, K+‑ATPase activity during the acute phase of gastric ulcer disease. A rat model of stress‑induced gastric ulcers was produced, in which the anti‑ulcer effects of curcumin were examined. Curcumin‑induced inhibition of the H+, K+‑ATPase promoter via histone acetylation, was verified using a chromatin immunoprecipitation assay. The results showed that curcumin improved stress‑induced gastric ulcer disease in rats, as demonstrated by increased pH values and reduced gastric mucosal hemorrhage and ulcer index. These effects were accompanied by a significant reduction in the level of histone H3 acetylation at the site of the H+, K+‑ATPase promoter and in the expression of the gastric H+,K+‑ATPase α subunit gene and protein. In conclusion, curcumin downregulated the acetylation of histone H3 at the site of the H+, K+‑ATPase promoter gene, thereby inhibiting the transcription and expression of the H+, K+‑ATPase gene. Curcumin was shown to have a preventive and therapeutic effect in gastric ulcer disease.

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Curcumin in tissue engineering: A traditional remedy for modern medicine

et al. 2018

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Curcumin is the principal polyphenolic compound present in turmeric with broad applications in tissue engineering and regenerative medicine. It has some important inherent properties with the potential to facilitate tissue healing, including anti‐inflammatory, anti‐oxidant, and antibacterial activities. Therefore, curcumin has been used for the treatment of various damaged tissues, especially wound injuries. There are different forms of curcumin, among which nano‐formulations are of a great importance in regenerative medicine. It is also important to design sophisticated delivery systems for controlled/localized delivery of curcumin to the target tissues and organs. Although there are many reports on the advantages of this compound, further research is required to fully explore its clinical usage. The review describes the physicochemical and biological properties of curcumin and the current state of the evidence on its applications in tissue engineering. © 2018 BioFactors, 45(2):135–151, 2019

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Curcumin Heals Indomethacin-Induced Gastric Ulceration by Stimulation of Angiogenesis and Restitution of Collagen FibersviaVEGF and MMP-2 Mediated Signaling

Abstract: We conclude that curcumin remodels gastric tissues by restoring the collagen architecture and accelerating angiogenesis.

Cited by 56 publications

References 35 publications

Phytochemicals in Wound Healing

Phytochemicals in Wound Healing

Curcumin-induced histone acetylation inhibition improves stress-induced gastric ulcer disease in rats

Curcumin in tissue engineering: A traditional remedy for modern medicine

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