Curcumin-encased hydroxyapatite nanoparticles as novel biomaterials for antimicrobial, antioxidant and anticancer applications: A perspective of nano-based drug delivery

Sebastiammal, S.; Fathima, A. Lesly; Devanesan, Sandhanasamy; AlSalhi, Mohamad S.; Henry, J.; Govindarajan, Marimuthu; Vaseeharan, Baskaralingam

doi:10.1016/j.jddst.2020.101752

Cited by 33 publications

(17 citation statements)

References 34 publications

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“…For the synthesis of nanoparticles, many physical and chemical methods are available which use toxic chemicals as a major constituent ( Kumar et al, 2013 , Suganya et al, 2017 , Ishwarya et al, 2017a , Iswarya et al, 2017b , Thaya et al, 2018 , Karthika et al, 2020 , Kiriyanthan et al, 2020 , Sebastiammal et al, 2020 ). So the need of the hour is to use greener, environmentally benign and eco-friendly routes for the synthesis of metallic nanoparticles ( Karthika et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of ZnO nanoparticles for antimicrobial and vegetative growth applications: A novel approach for advancing efficient high quality health care to human wellbeing

Umavathi¹,

Mahboob

Govindarajan

et al. 2021

Saudi Journal of Biological Sciences

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The present work aims to synthesize zinc oxide (ZnO) nanoparticles via green approaches using leaf extract of Parthenium hysterophorus . UV–vis and FT-IR tests confirmed the existence of biomolecules, active materials, and metal oxides. The X-ray diffraction structural study exposes the ZnO nanoparticles formation with hexagonal phase structures. SEM and TEM analysis reveal surface morphologies of ZnO nanoparticles and most of them are spherical with a size range of 10 nm. ZnO nanoparticles were revealed strong antimicrobial activity against both bacterial and fungal strains. The germination of seeds and vegetative growth of Sesamum indicum has been greatly improved.

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Section: Introductionmentioning

confidence: 99%

Green synthesis of ZnO nanoparticles for antimicrobial and vegetative growth applications: A novel approach for advancing efficient high quality health care to human wellbeing

Umavathi¹,

Mahboob

Govindarajan

et al. 2021

Saudi Journal of Biological Sciences

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“…The progress to scalable production needs to comply with good manufacturing practice (GMP) standards for ensuring successful translation to the clinic and determining the way in which the scaffolds will be delivered and made available to the clinician. Delivery capability: It is essential to mention that delivery capability through the releasing biological active agents can induce important properties such as faster healing [ 44 , 45 ], antimicrobial [ 46 , 47 , 48 ], and antitumoral activity [ 49 , 50 ]. “In depth” osteointegration: This requirement is strongly correlated with the pore size and porosity but also with the nature of the biomaterial.…”

Section: Biomaterials Scaffoldsmentioning

confidence: 99%

“…Delivery capability: It is essential to mention that delivery capability through the releasing biological active agents can induce important properties such as faster healing [ 44 , 45 ], antimicrobial [ 46 , 47 , 48 ], and antitumoral activity [ 49 , 50 ].…”

Section: Biomaterials Scaffoldsmentioning

confidence: 99%

Advances in Osteoporotic Bone Tissue Engineering

Codrea

Croitoru

Baciu

et al. 2021

JCM

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The increase in osteoporotic fracture worldwide is urging bone tissue engineering research to find new, improved solutions both for the biomaterials used in designing bone scaffolds and the anti-osteoporotic agents capable of promoting bone regeneration. This review aims to report on the latest advances in biomaterials by discussing the types of biomaterials and their properties, with a special emphasis on polymer-ceramic composites. The use of hydroxyapatite in combination with natural/synthetic polymers can take advantage of each of their components properties and has a great potential in bone tissue engineering, in general. A comparison between the benefits and potential limitations of different scaffold fabrication methods lead to a raised awareness of the challenges research face in dealing with osteoporotic fracture. Advances in 3D printing techniques are providing the ways to manufacture improved, complex, and specialized 3D scaffolds, capable of delivering therapeutic factors directly at the osteoporotic skeletal defect site with predefined rate which is essential in order to optimize the osteointegration/healing rate. Among these factors, strontium has the potential to increase osseointegration, osteogenesis, and healing rate. Strontium ranelate as well as other biological active agents are known to be effective in treating osteoporosis due to both anti-resorptive and anabolic properties but has adverse effects that can be reduced/avoided by local release from biomaterials. In this manner, incorporation of these agents in polymer-ceramic composites bone scaffolds can have significant clinical applications for the recovery of fractured osteoporotic bones limiting or removing the risks associated with systemic administration.

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“…Up until now, researchers have focused on nanoparticle-based biocompatible materials, which are increasingly prevalent and used in a variety of potential biomedical engineering applications, including drug delivery systems [ 24 ], wound healing [ 25 , 26 ], tissue engineering [ 20 , 27 ], dentistry [ 28 , 29 ], cancer therapy [ 30 ] and other related research areas. Despite their interesting applications, research into the use of nanoparticles as biomaterials is also broad [ 31 , 32 , 33 ]. The nanoparticle-incorporated biomaterials provide a perfect composite material, demonstrating new or improved properties and activated therapeutics.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Nanoparticle-Incorporated Natural-Based Biomaterials towards Cells on Activated Pathways: A Systematic Review

et al. 2022

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The advancement of natural-based biomaterials in providing a carrier has revealed a wide range of benefits in the biomedical sciences, particularly in wound healing, tissue engineering and regenerative medicine. Incorporating nanoparticles within polymer composites has been reported to enhance scaffolding performance, cellular interactions and their physico-chemical and biological properties in comparison to analogue composites without nanoparticles. This review summarized the current knowledge of nanoparticles incorporated into natural-based biomaterials with effects on their cellular interactions in wound healing. Although the mechanisms of wound healing and the function of specific cells in wound repair have been partially described, many of the underlying signaling pathways remain unknown. We also reviewed the current understanding and new insights into the wingless/integrated (Wnt)/β-catenin pathway and other signaling pathways of transforming growth factor beta (TGF-β), Notch, and Sonic hedgehog during wound healing. The findings demonstrated that most of the studies reported positive outcomes of biomaterial scaffolds incorporated with nanoparticles on cell attachment, viability, proliferation, and migration. Combining therapies consisting of nanoparticles and biomaterials could be promising for future therapies and better outcomes in tissue engineering and regenerative medicine.

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Curcumin-encased hydroxyapatite nanoparticles as novel biomaterials for antimicrobial, antioxidant and anticancer applications: A perspective of nano-based drug delivery

Cited by 33 publications

References 34 publications

Green synthesis of ZnO nanoparticles for antimicrobial and vegetative growth applications: A novel approach for advancing efficient high quality health care to human wellbeing

Green synthesis of ZnO nanoparticles for antimicrobial and vegetative growth applications: A novel approach for advancing efficient high quality health care to human wellbeing

Advances in Osteoporotic Bone Tissue Engineering

The Effect of Nanoparticle-Incorporated Natural-Based Biomaterials towards Cells on Activated Pathways: A Systematic Review

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