Curcumin effects on blood lipid profile in a 6-month human study

Baum, Larry; Cheung, Stanley Kwok Kuen; Mok, Vincent; Lam, Linda C.W.; Leung, Vivian; Hui, Elsie; Ng, Chelsia; Chow, Moses S. S.; Ho, Ping C.; Lam, Sherry S. L.

doi:10.1016/j.phrs.2007.09.013

Cited by 128 publications

(96 citation statements)

References 14 publications

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“…The hypocholesterolemic effect of Turmeric reported to be due to up-regulation of cholesterol 7α-hydroxylase in rats (Kim and Kim 2010). Hypolipidemic and hypocholesterolemic effect of Black cumin seed come in accordance with previous research in rats (Baum et al, 2007;Kocyigit et al, 2009;Nader et al, 2010). In the contrary, hypercholesterolemic and hyperlipidemic effects followed oral administration of Black cumin seed (2%) in Pekin ducklings were recorded (El-Bahr and Saad, 2008).…”

Section: Tablesupporting

confidence: 83%

“…Administration of 500 mg curcumin to human volunteers for one week did not produce significant change in serum cholesterol level (Soni and Kuttan 1992). Additionally, consumption of Curcumin over 1 month or 6 months was reported not to affect blood concentrations of TG, or TC, LDL, and HDL-c (Baum et al, 2007). The hypocholesterolemic effect of Turmeric reported to be due to up-regulation of cholesterol 7α-hydroxylase in rats (Kim and Kim 2010).…”

Section: Tablementioning

confidence: 99%

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Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats

El-Bahr¹,

Taha²,

Korshom³

et al. 2014

AJVS

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Key wordsABSTRACT: Diabetes mellitus, blood glucose, body weight, water intake, food intake.The objective of the present study was to investigate the effect of Turmeric (Curcuma Longa) and Black cumin seed (Nigella Sativa) mixture on selected biochemical parameters of streptozotocin (STZ) induced diabetic rats. Therefore, twenty one healthy adult albino rats divided into three groups (7 rats in each). Rats of first and second groups were non diabetic and diabetic respectively. Rats of the third group were diabetic and received a mixture of Turmeric (0.5 g/kg b .wt.) and Black cumin seed (1 g/kg b.wt.) orally by intragastric intubations once a day for six weeks. The changes in blood glucose level, body weight and water and food intake were measured. In addition, selected biochemical parameters were also determined. The present study revealed that, dietary supplementation of plant mixture of Turmeric and Black cumin seed to diabetic rats significantly (P<0.05) reduced the blood glucose level as well as water and food intake accompanied by an increase in body weight gain when compared with untreated diabetic rats. Proteins were not affected whereas liver and kidney functions were disrupted in STZ-diabetic rats and restored whenever treated by medicinal plants mixture. Hypercholesterolemia and hyperlipidemia observed in STZdiabetic rats were attenuated by administration of examined medicinal plants combination. Conclusively, dietary supplementation of Turmeric and Black cumin seed mixture reduced blood glucose level and ameliorated the hypercholesterolemia and hyperlipidemia in STZ induced diabetic rats.

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Section: Tablesupporting

confidence: 83%

Section: Tablementioning

confidence: 99%

Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats

El-Bahr¹,

Taha²,

Korshom³

et al. 2014

AJVS

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“…The previous clinical study has also verified significant data from a study with human subjects. Patients took capsules of curcumin (1 or 4 g/day) for 6 months that exhibited a mean level of curcumin concentration of 0.49 µmol/l in plasma and the high dose curcumin (4 g/day) has not toxical effects on human body [3]. Our results also were similar with previous publications that curcumin was able to significantly reduce the MDA level and oxygen radical production at concentrations of 0.01, 0.1, 0.5 and 1 µmol/l [2].…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, turmeric has been used in traditional ayurvedic and chinese medicine since 3000 B.C. for treating a wide variety of diseases, including coughs, diabetes, hepatic disorders, rheumatism and various types of cancer [1,2,3]. …”

Section: Introductionmentioning

confidence: 99%

Effects of Three Kinds of Curcuminoids on Anti-Oxidative System and Membrane Deformation of Human Peripheral Blood Erythrocytes in High Glucose Levels

Yang

et al. 2015

Cell Physiol Biochem

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Background/Aims: Curcuminoids are the main bioactive constituents of the rhizome of turmeric. Erythrocytes lesions in diabetes are probably related to hyperglycemia and protein glycation. It has been reported that curcumin prevent lipid peroxidation. However, reports on the effects of demethoxycurcumin and bis-demethoxycurcumin on human erythrocytes at high glucose levels are scarce. Our aim is to investigate the effect of curcuminoids on oxidative stress and membrane of erythrocytes exposed to hyperglycemic condition. Methods: In this study, the different blood samples were treated with two doses of glucose (10 or 30 mM) to mimic hyperglycemia in the presence or absence of three kinds of curcuminoids (5 or 10 μM) in a medium at 37 °C for 24 h (Each experiment consists of 20 blood samples from 10 male and 10 female volunteers). The malondialdehyde was checked by HPLC, antioxidase (GSH and GSSG) were measured by LC/MS, SOD was checked by WST-1 kit, morphology and phospholipid symmetry were detected by flow cytometry, confocal scanning microscope and scanning electron microscope. Results: The results illustrated that all three curcuminoids reduce oxidative stress damage on the membrane and maintain a better profile for erythrocytes. Furthermore, three curcuminoids had benefit effects on antioxidase. Conclusion: The three kinds of curcuminoids supplementation may prevent lipid peroxidation at different intensity and membrane dysfunction of human erythrocytes in hyperglycemia.

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“…Where phytochemicals (I3C, tea polyphenols, and curcumin) have been investigated in extended trials, they have been associated with very few side effects (41)(42)(43)52). Nonetheless, some adverse effects have been reported, e.g., moderate and significant toxicity for green tea (6 grams/day) and green tea extract, presumably attributed to caffeine (53,54).…”

Section: Physiologic Concentrationsmentioning

confidence: 99%

Dietary Chemopreventive Phytochemicals: Too Little or Too Much?

Moiseeva

Manson

2009

Cancer Prevention Research

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There is a large body of evidence that the consumption of fruit and vegetables can decrease the risk of cancer. However, the link between diet and health is extremely complex. Some dietary phytochemicals seem to offer protection in an exposure-related manner and many molecular targets and signaling pathways affected by phytochemicals have been discovered. Although in vitro studies have contributed significantly to our understanding, quite a number use concentrations orders of magnitude greater than those achievable in humans or toxic to normal tissues (exemplified by toxic concentrations of indole-3-carbinol, epigallocatechin-3-gallate, curcumin, and genistein for breast cells). Such studies may produce results that are physiologically irrelevant, thus hindering predictions of efficacy. Here, we argue for careful consideration to be given to the in vitro experimental conditions under which dietary phytochemicals are investigated. Design features, such as the use of appropriate nontoxic concentrations, extended treatment times, three-dimensional cultures, primary tumor cultures, and comparison of susceptibility of various cancer subtypes, should improve our understanding of their molecular targets. This in turn would facilitate predictions as to their potential usefulness in the clinic. Chemopreventive Effect of Vegetables and FruitDiet is thought to contribute to a significant proportion of cancer cases and about a third of mortalities (1). Several international committees previously concluded that consumption of fruit and vegetables decreases the risk of cancer (2-4). More recently, the second WCRF-AICR report (5) found that overall, the evidence that vegetables and fruit protect against cancer is less impressive. However, among specific groups, Allium vegetables and garlic were considered to offer probable protection against stomach and colorectal cancers, respectively. Other groups, e.g., cruciferous vegetables [source of isothiocyanates (ITC) and indoles] or tea (source of polyphenols), received little attention in this report. The International Agency for Research on Cancer concluded that consumption of cruciferous vegetables is associated with a modest risk reduction for cancers at some sites, although the reductions are no greater than those observed with total vegetable uptake (6).Because of insufficient evidence, the conclusions of the latest WCRF-AICR report have somewhat undermined the hypothesis that specific phytochemicals, present in vegetables and fruit, may be responsible for chemoprevention. This lack of convincing evidence is partly because important contributing factors were not considered in many of the original studies. Many based on self-reporting are found to be biased. Factors, such as tobacco, gene polymorphisms, and body composition, can modify cancer risk (5). Significant differences in levels of consumed vegetables, and consequently dietary phytochemicals, are found among various populations. For example, the highest levels of cruciferous vegetable uptake in Europe and North A...

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Curcumin effects on blood lipid profile in a 6-month human study

Cited by 128 publications

References 14 publications

Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats

Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats

Effects of Three Kinds of Curcuminoids on Anti-Oxidative System and Membrane Deformation of Human Peripheral Blood Erythrocytes in High Glucose Levels

Dietary Chemopreventive Phytochemicals: Too Little or Too Much?

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